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Gene Review

gja1  -  gap junction protein, alpha 1, 43kDa

Xenopus (Silurana) tropicalis

Synonyms: connexin43, cx43, dfnb38, gjal, oddd
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High impact information on LOC394450

  • The alpha 1 and alpha 2 mRNAs encode proteins with different degrees of amino acid sequence similarity to the predominant gap junction subunit of the mammalian heart (connexin 43) [1].
  • Expression of connexin-32 in one and connexin-43 in the other oocyte of a pair results in the formation of junctional conductances at rates similar to those observed when only one or the other connexin is expressed in both oocytes of a pair [2].
  • Connexin 43 expression in glial cells of developing rhombomeres of Xenopus laevis [3].
  • Cells of rhombomeric center regions and their processes in the outlying neuropil co-expressed glial fibrillary acidic protein and connexin 43 at a time that is characterized by the emergence of hindbrain auditory neural circuitry [3].
  • Connexin 43 is a gap junctional protein found predominantly in astrocytes [3].

Biological context of LOC394450


Anatomical context of LOC394450

  • The oocyte cell-cell channel assay was used to demonstrate that connexin-43 is a cell-cell channel-forming protein as previously shown for connexin-32 [2].
  • Glial fibrillary acidic protein positive glial cells that appeared at rhombomeric boundaries never expressed connexin 43, but rather appeared to physically bisect ventricular convexities into adjacent rhombomeric regions [3].


  1. Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos. Gimlich, R.L., Kumar, N.M., Gilula, N.B. J. Cell Biol. (1990) [Pubmed]
  2. Formation of hybrid cell-cell channels. Werner, R., Levine, E., Rabadan-Diehl, C., Dahl, G. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Connexin 43 expression in glial cells of developing rhombomeres of Xenopus laevis. Katbamna, B., Jelaso, A.M., Ide, C.F. Int. J. Dev. Neurosci. (2004) [Pubmed]
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