Gene Review:
GJA1 - gap junction protein, alpha 1, 43kDa
Homo sapiens
Synonyms:
AVSD3, CMDR, CX43, Connexin-43, Cx43, ...
Nagy,
Khandoga,
Gorter,
Hundhausen,
Pohl,
Hertzberg,
Saffitz,
Nagel,
Hüsing,
Griffin,
Purcell,
Moll,
Leenstra,
Laing,
Jansen,
Otsu,
Sáez,
Aronica,
Troost,
Keller,
Verlaan,
Giepmans,
Yamada,
Yankaya,
Manley-Markowski,
Rogers,
Richard,
Steinberg,
Yabuki,
Hori,
Toyofuku,
Kuzuya,
Lampe,
Bennett,
Nguyen,
Olerud,
Contreras,
Usui,
Lidington,
Sundset,
Tada,
Bukauskas,
Brandner,
Koval,
Marotta,
Li,
Tada,
Ratajczak,
Kuzuya,
Steinberg,
Kaiser,
Toyofuku,
Akamatsu,
Civitelli,
Sawa Kostin,
Moolenaar,
Kameritsch,
Takada,
Hori,
Carter,
Kelly,
Zhang,
Houdek,
Gil,
- Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and Angiogenesis. McLachlan, E., Shao, Q., Wang, H.L., Langlois, S., Laird, D.W. Cancer Res. (2006)
- Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumours. Jamieson, S., Going, J.J., D'Arcy, R., George, W.D. J. Pathol. (1998)
- Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Aronica, E., Gorter, J.A., Jansen, G.H., Leenstra, S., Yankaya, B., Troost, D. Acta Neuropathol. (2001)
- Zonula occludens-1 and connexin 43 expression in the failing human heart. Kostin, S. J. Cell. Mol. Med. (2007)
- Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer's disease. Nagy, J.I., Li, W., Hertzberg, E.L., Marotta, C.A. Brain Res. (1996)
- New roles for astrocytes: gap junction hemichannels have something to communicate. Bennett, M.V., Contreras, J.E., Bukauskas, F.F., Sáez, J.C. Trends Neurosci. (2003)
- Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368. Richards, T.S., Dunn, C.A., Carter, W.G., Usui, M.L., Olerud, J.E., Lampe, P.D. J. Cell Biol. (2004)
- Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication. Lampe, P.D., Nguyen, B.P., Gil, S., Usui, M., Olerud, J., Takada, Y., Carter, W.G. J. Cell Biol. (1998)
- Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin. Govindarajan, R., Zhao, S., Song, X.H., Guo, R.J., Wheelock, M., Johnson, K.R., Mehta, P.P. J. Biol. Chem. (2002)
- Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia. Déglise, S., Martin, D., Probst, H., Saucy, F., Hayoz, D., Waeber, G., Nicod, P., Ris, H.B., Corpataux, J.M., Haefliger, J.A. J. Vasc. Surg. (2005)
- Mutations in the second extracellular region of connexin 43 prevent localization to the plasma membrane, but do not affect its ability to suppress cell growth. Olbina, G., Eckhart, W. Mol. Cancer Res. (2003)
- pp60src-mediated phosphorylation of connexin 43, a gap junction protein. Loo, L.W., Berestecky, J.M., Kanemitsu, M.Y., Lau, A.F. J. Biol. Chem. (1995)
- A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Flenniken, A.M., Osborne, L.R., Anderson, N., Ciliberti, N., Fleming, C., Gittens, J.E., Gong, X.Q., Kelsey, L.B., Lounsbury, C., Moreno, L., Nieman, B.J., Peterson, K., Qu, D., Roscoe, W., Shao, Q., Tong, D., Veitch, G.I., Voronina, I., Vukobradovic, I., Wood, G.A., Zhu, Y., Zirngibl, R.A., Aubin, J.E., Bai, D., Bruneau, B.G., Grynpas, M., Henderson, J.E., Henkelman, R.M., McKerlie, C., Sled, J.G., Stanford, W.L., Laird, D.W., Kidder, G.M., Adamson, S.L., Rossant, J. Development (2005)
- Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. Paznekas, W.A., Boyadjiev, S.A., Shapiro, R.E., Daniels, O., Wollnik, B., Keegan, C.E., Innis, J.W., Dinulos, M.B., Christian, C., Hannibal, M.C., Jabs, E.W. Am. J. Hum. Genet. (2003)
- Human connexin43 gene locus, GJA1, sublocalized to band 6q21-->q23.2. Corcos, I.A., Meese, E.U., Loch-Caruso, R. Cytogenet. Cell Genet. (1993)
- Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomes. Hsieh, C.L., Kumar, N.M., Gilula, N.B., Francke, U. Somat. Cell Mol. Genet. (1991)
- A novel GJA 1 mutation in oculo-dento-digital dysplasia with curly hair and hyperkeratosis. Kelly, S.C., Ratajczak, P., Keller, M., Purcell, S.M., Griffin, T., Richard, G. European journal of dermatology : EJD. (2006)
- A novel mutation in the GJA1 gene in a family with oculodentodigital dysplasia. Vasconcellos, J.P., Melo, M.B., Schimiti, R.B., Bressanim, N.C., Costa, F.F., Costa, V.P. Arch. Ophthalmol. (2005)
- Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin 43, 32, or 26. Paemeleire, K., Martin, P.E., Coleman, S.L., Fogarty, K.E., Carrington, W.A., Leybaert, L., Tuft, R.A., Evans, W.H., Sanderson, M.J. Mol. Biol. Cell (2000)
- Assembly of chimeric connexin-aequorin proteins into functional gap junction channels. Reporting intracellular and plasma membrane calcium environments. Martin, P.E., George, C.H., Castro, C., Kendall, J.M., Capel, J., Campbell, A.K., Revilla, A., Barrio, L.C., Evans, W.H. J. Biol. Chem. (1998)
- Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations. Oviedo-Orta, E., Hoy, T., Evans, W.H. Immunology (2000)
- Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Wang, M., Martínez, A.D., Berthoud, V.M., Seul, K.H., Gemel, J., Valiunas, V., Kumari, S., Brink, P.R., Beyer, E.C. Biochem. Biophys. Res. Commun. (2005)
- Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40. Dhein, S., Polontchouk, L., Salameh, A., Haefliger, J.A. Biol. Cell (2002)
- Pressure induces loss of gap junction communication and redistribution of connexin 43 in astrocytes. Malone, P., Miao, H., Parker, A., Juarez, S., Hernandez, M.R. Glia (2007)
- Connexin-43 interactions with ZO-1 and alpha- and beta-tubulin. Giepmans, B.N., Verlaan, I., Moolenaar, W.H. Cell Commun. Adhes. (2001)
- c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. Toyofuku, T., Akamatsu, Y., Zhang, H., Kuzuya, T., Tada, M., Hori, M. J. Biol. Chem. (2001)
- Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells. Laing, J.G., Manley-Markowski, R.N., Koval, M., Civitelli, R., Steinberg, T.H. J. Biol. Chem. (2001)
- Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation. Cameron, S.J., Malik, S., Akaike, M., Lerner-Marmarosh, N., Yan, C., Lee, J.D., Abe, J., Yang, J. J. Biol. Chem. (2003)
- Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. Giepmans, B.N., Hengeveld, T., Postma, F.R., Moolenaar, W.H. J. Biol. Chem. (2001)
- Up-regulation of connexin45 in heart failure. Yamada, K.A., Rogers, J.G., Sundset, R., Steinberg, T.H., Saffitz, J.E. J. Cardiovasc. Electrophysiol. (2003)
- Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology. Huang, R., Lin, Y., Wang, C.C., Gano, J., Lin, B., Shi, Q., Boynton, A., Burke, J., Huang, R.P. Cancer Res. (2002)
- Intercellular calcium signaling via gap junction in connexin-43-transfected cells. Toyofuku, T., Yabuki, M., Otsu, K., Kuzuya, T., Hori, M., Tada, M. J. Biol. Chem. (1998)
- Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules. Kameritsch, P., Khandoga, N., Nagel, W., Hundhausen, C., Lidington, D., Pohl, U. J. Cell. Physiol. (2005)
- Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells. Vikhamar, G., Rivedal, E., Mollerup, S., Sanner, T. Cell Adhes. Commun. (1998)
- Molecular dissection of transjunctional voltage dependence in the connexin-32 and connexin-43 junctions. Revilla, A., Castro, C., Barrio, L.C. Biophys. J. (1999)
- Gap junction protein phenotypes of the human heart and conduction system. Davis, L.M., Rodefeld, M.E., Green, K., Beyer, E.C., Saffitz, J.E. J. Cardiovasc. Electrophysiol. (1995)
- SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. II. Changes in gap junctional intercellular communication. Khoo, N.K., Zhang, Y., Bechberger, J.F., Bond, S.L., Hum, K., Lala, P.K. Int. J. Cancer (1998)
- Connexins 26, 30, and 43: differences among spontaneous, chronic, and accelerated human wound healing. Brandner, J.M., Houdek, P., Hüsing, B., Kaiser, C., Moll, I. J. Invest. Dermatol. (2004)
- Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Chen, Z., Evans, W.H., Pflugfelder, S.C., Li, D.Q. Stem Cells (2006)