High impact information on FMOD

• Differential expression of fibromodulin mRNA associated with tendon fibril growth: isolation and characterization of a chicken fibromodulin cDNA [1].
• Features unique to chicken fibromodulin include an additional glycosylation site as well as a decreased number of tyrosine residues that could be sulphated, and therefore potential changes in the charge of the molecule [1].
• There was an up-regulation of structural proteins (for example, collagen types I, VI, and XI and fibromodulin), a number of regulatory proteins (including TGF-beta 2 and IGF-1), as well as other enzymes/proteins [2].
• SDS-PAGE indicated that decorin was present in all regions and fibromodulin was mainly observed in the tensile region [3].

Anatomical context of FMOD

• A 450 bp cDNA fragment similar to that encoding bovine fibromodulin was isolated using a screening procedure to isolate genes differentially expressed between the pre- and post-growth phases of fibril growth in the developing chicken embryo metatarsal tendon [1].

Analytical, diagnostic and therapeutic context of FMOD

• Northern blot analysis revealed a 6-8-fold increase in the fibromodulin mRNA level from day 14 to day 19 of development [1].
• Immunoblotting of these proteins was positive for the small proteoglycans fibromodulin and decorin, respectively [4].

References