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Gene Review

Fmod  -  fibromodulin

Rattus norvegicus

Synonyms: Collagen-binding 59 kDa protein, FM, Fibromodulin, KSPG fibromodulin, Keratan sulfate proteoglycan fibromodulin
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Disease relevance of Fmod


High impact information on Fmod

  • This inverse relationship between fibromodulin expression and scarring in both fetal and adult rat wound repair suggests that fibromodulin may be a biologically relevant modulator of TGF-beta activity during scar formation [2].
  • Immunostaining demonstrated significant fibromodulin induction 36 hours after injury in gestation day 16, but not day 19, fetal wounds [2].
  • Immunocytochemistry showed intense immunostaining of biglycan and fibromodulin in the areas of injured lung tissue from rats 14 and 28 d after BM administration [1].
  • Biglycan was increased in BM lung strips at all time points, FM and elastic fibers were increased at 14 and 28 d, and collagen was increased at 28 d only [3].
  • Comparisons of glycosaminoglycan and proteoglycan label allowed extrapolations to be made as to likely glycosaminoglycan components of the large proteoglycans, and of other proteoglycans that may be present - thus differential distribution of aggrecan and keratan sulfate label suggested the presence of fibromodulin and/or lumican [4].

Anatomical context of Fmod


Associations of Fmod with chemical compounds

  • Thus, FM was reported to have nialamide like activity, whereas FO actions were dopaminergic in nature [5].

Other interactions of Fmod

  • Differential expression of keratan sulphate proteoglycans fibromodulin, lumican and aggrecan in normal and fibrotic rat liver [6].
  • The PCR analysis further showed that the expression of decorin and fibromodulin was relatively reduced against type I procollagen by the growth factor, which was considered to be responsible for the increase of collagen fibril diameter in the repair tissue [7].
  • PRELP and fibromodulin mainly outlined the soft tissues surrounding the graft and compact bone sealing off the graft marrow [8].


  1. Alterations in large and small proteoglycans in bleomycin-induced pulmonary fibrosis in rats. Venkatesan, N., Ebihara, T., Roughley, P.J., Ludwig, M.S. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  2. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Soo, C., Hu, F.Y., Zhang, X., Wang, Y., Beanes, S.R., Lorenz, H.P., Hedrick, M.H., Mackool, R.J., Plaas, A., Kim, S.J., Longaker, M.T., Freymiller, E., Ting, K. Am. J. Pathol. (2000) [Pubmed]
  3. Changes in extracellular matrix and tissue viscoelasticity in bleomycin-induced lung fibrosis. Temporal aspects. Ebihara, T., Venkatesan, N., Tanaka, R., Ludwig, M.S. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  4. Extracellular matrix in development of the intervertebral disc. Hayes, A.J., Benjamin, M., Ralphs, J.R. Matrix Biol. (2001) [Pubmed]
  5. Neuropharmacological studies on Fusarium toxins-III: Neurochemical investigations on total toxin extracts from F. moniliforme and F. oxysporum. Ganguli, S., Hota, D., Goel, R.K., Acharya, S.B., Bhattacharya, S.K. Indian J. Exp. Biol. (1996) [Pubmed]
  6. Differential expression of keratan sulphate proteoglycans fibromodulin, lumican and aggrecan in normal and fibrotic rat liver. Krull, N.B., Gressner, A.M. FEBS Lett. (1992) [Pubmed]
  7. Effect of GDF-5 on ligament healing. Tashiro, T., Hiraoka, H., Ikeda, Y., Ohnuki, T., Suzuki, R., Ochi, T., Nakamura, K., Fukui, N. J. Orthop. Res. (2006) [Pubmed]
  8. Effect of cortical perforations of both graft and host bed on onlay incorporation to the rat skull. Alberius, P., Gordh, M., Lindberg, L., Johnell, O. Eur. J. Oral Sci. (1996) [Pubmed]
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