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Gene Review

FMOD  -  fibromodulin

Homo sapiens

Synonyms: Collagen-binding 59 kDa protein, FM, Fibromodulin, KSPG fibromodulin, Keratan sulfate proteoglycan fibromodulin, ...
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Disease relevance of FMOD


High impact information on FMOD


Biological context of FMOD


Anatomical context of FMOD


Associations of FMOD with chemical compounds


Other interactions of FMOD


Analytical, diagnostic and therapeutic context of FMOD


  1. Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. Mayr, C., Bund, D., Schlee, M., Moosmann, A., Kofler, D.M., Hallek, M., Wendtner, C.M. Blood (2005) [Pubmed]
  2. Fibromodulin is expressed in leiomyoma and myometrium and regulated by gonadotropin-releasing hormone analogue therapy and TGF-beta through Smad and MAPK-mediated signalling. Levens, E., Luo, X., Ding, L., Williams, R.S., Chegini, N. Mol. Hum. Reprod. (2005) [Pubmed]
  3. Mice deficient in biglycan and fibromodulin as a model for temporomandibular joint osteoarthritis. Wadhwa, S., Embree, M., Ameye, L., Young, M.F. Cells Tissues Organs (Print) (2005) [Pubmed]
  4. Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. Mikaelsson, E., Danesh-Manesh, A.H., Lüppert, A., Jeddi-Tehrani, M., Rezvany, M.R., Sharifian, R.A., Safaie, R., Roohi, A., Osterborg, A., Shokri, F., Mellstedt, H., Rabbani, H. Blood (2005) [Pubmed]
  5. Immunohistochemical localization and expression of fibromodulin in adult rat periodontium and inflamed human gingiva. Qian, H., Xiao, Y., Bartold, P.M. Oral diseases. (2004) [Pubmed]
  6. Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. Sztrolovics, R., Chen, X.N., Grover, J., Roughley, P.J., Korenberg, J.R. Genomics (1994) [Pubmed]
  7. Structure and deduced amino acid sequence of the human fibromodulin gene. Antonsson, P., Heinegård, D., Oldberg, A. Biochim. Biophys. Acta (1993) [Pubmed]
  8. Polymorphonuclear leukocyte adhesion to articular cartilage is inhibited by cartilage surface macromolecules. Mitani, Y., Honda, A., Jasin, H.E. Rheumatol. Int. (2001) [Pubmed]
  9. Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican. Schaefer, L., Gröne, H.J., Raslik, I., Robenek, H., Ugorcakova, J., Budny, S., Schaefer, R.M., Kresse, H. Kidney Int. (2000) [Pubmed]
  10. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Barry, F., Boynton, R.E., Liu, B., Murphy, J.M. Exp. Cell Res. (2001) [Pubmed]
  11. The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. Sjöberg, A., Onnerfjord, P., Mörgelin, M., Heinegård, D., Blom, A.M. J. Biol. Chem. (2005) [Pubmed]
  12. Proteoglycan-Lb, a small dermatan sulfate proteoglycan expressed in embryonic chick epiphyseal cartilage, is structurally related to osteoinductive factor. Shinomura, T., Kimata, K. J. Biol. Chem. (1992) [Pubmed]
  13. Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage. Cs-Szabó, G., Roughley, P.J., Plaas, A.H., Glant, T.T. Arthritis Rheum. (1995) [Pubmed]
  14. Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development. Nishimoto, S.K., Nishimoto, M. Matrix Biol. (2005) [Pubmed]
  15. Fibromodulin binds collagen type I via Glu-353 and Lys-355 in leucine-rich repeat 11. Kalamajski, S., Oldberg, A. J. Biol. Chem. (2007) [Pubmed]
  16. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Hildebrand, A., Romarís, M., Rasmussen, L.M., Heinegård, D., Twardzik, D.R., Border, W.A., Ruoslahti, E. Biochem. J. (1994) [Pubmed]
  17. Human granulation-tissue fibroblasts show enhanced proteoglycan gene expression and altered response to TGF-beta 1. Häkkinen, L., Westermarck, J., Kähäri, V.M., Larjava, H. J. Dent. Res. (1996) [Pubmed]
  18. The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia. Adesida, A.B., Grady, L.M., Khan, W.S., Hardingham, T.E. Arthritis Res. Ther. (2006) [Pubmed]
  19. Structural requirements for fibromodulin binding to collagen and the control of type I collagen fibrillogenesis--critical roles for disulphide bonding and the C-terminal region. Font, B., Eichenberger, D., Goldschmidt, D., Boutillon, M.M., Hulmes, D.J. Eur. J. Biochem. (1998) [Pubmed]
  20. Expression of collagen and fiber-associated proteins in human septal cartilage during in vitro dedifferentiation. Goessler, U.R., Bugert, P., Bieback, K., Baisch, A., Sadick, H., Verse, T., Klüter, H., Hörmann, K., Riedel, F. Int. J. Mol. Med. (2004) [Pubmed]
  21. Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development. Gori, F., Schipani, E., Demay, M.B. J. Cell. Biochem. (2001) [Pubmed]
  22. The serine protease inhibitor trappin-2 is present in cartilage and synovial fluid in osteoarthritis. Jaovisidha, K., Etim, A., Yamakawa, K., Masuda, I., Gohr, C.M., Wakim, B.T., Boonapatcharoen, N., Ninomiya, J., Rosenthal, A.K. J. Rheumatol. (2006) [Pubmed]
  23. Age-related changes in fibromodulin and lumican in human intervertebral discs. Sztrolovics, R., Alini, M., Mort, J.S., Roughley, P.J. Spine. (1999) [Pubmed]
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