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Gene Review

Fmod  -  fibromodulin

Mus musculus

Synonyms: AI131919, AU041740, Collagen-binding 59 kDa protein, FM, Fibromodulin, ...
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Disease relevance of Fmod


High impact information on Fmod

  • Similar repeats have been found in two other proteoglycans, biglycan and fibromodulin, and in several other proteins including Drosophila morphogenetic proteins [4].
  • The observed increased ratio of fibromodulin to lumican and a competition for the same binding site could mediate these transitions [5].
  • Fibromodulin-deficient tendons were comparable with the lumican-null in early developmental periods and acquired a severe phenotype by maturation [5].
  • These studies indicate that lumican and fibromodulin have different developmental stage and leucine-rich repeat protein specific functions in the regulation of fibrillogenesis [5].
  • The double-deficient mice had a phenotype that was additive early and comparable with the fibromodulin-deficient mice at maturation [5].

Biological context of Fmod


Anatomical context of Fmod

  • Lumican and fibromodulin regulate the assembly of collagens into higher order fibrils in connective tissues [1].
  • Interestingly, no underlying ultrastructural or fibril abnormalities within the articular cartilage could be identified to explain why FM-null cartilage is more prone to pathological changes than wild-type tissue [2].
  • CONCLUSION: This report indicates for the first time that FM-null mice have a higher propensity towards degenerative changes in their knee joints than comparable WT animals [2].
  • These results indicate that DCN, in addition to its effects on fibrillogenesis, plays a regulatory role in angiogenesis and that FMOD in endothelial cells may be able to partially substitute for DCN [8].
  • Moreover, blood vessels of DCN-deficient mice exhibited a similar expression level of BGN as control mice, while FMOD was increased on day 3 after injury [8].

Associations of Fmod with chemical compounds

  • Lumican and fibromodulin are collagen-binding leucine-rich proteoglycans widely distributed in interstitial connective tissues [9].
  • Sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed several low molecular mass proteins which reacted with 5-D-4, specific for keratan sulfate, one of which showed characteristics of fibromodulin [10].
  • A comparative profile of action reveals that the neuropharmacological action of FM are qualitatively similar to those induced by nialamide, and likely to be due to inhibition of MAO [11].

Physical interactions of Fmod

  • In tissues like the tendon, where both proteoglycans are present, fibromodulin may be required early in collagen fibrillogenesis to stabilize small-diameter fibril-intermediates and lumican may be needed at a later stage, primarily to limit lateral growth of fibrils[9]

Other interactions of Fmod


Analytical, diagnostic and therapeutic context of Fmod


  1. A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice. Jepsen, K.J., Wu, F., Peragallo, J.H., Paul, J., Roberts, L., Ezura, Y., Oldberg, A., Birk, D.E., Chakravarti, S. J. Biol. Chem. (2002) [Pubmed]
  2. Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry. Gill, M.R., Oldberg, A., Reinholt, F.P. Osteoarthr. Cartil. (2002) [Pubmed]
  3. Oral administration of exopolysaccharide from Aphanothece halophytica (Chroococcales) significantly inhibits influenza virus (H1N1)-induced pneumonia in mice. Zheng, W., Chen, C., Cheng, Q., Wang, Y., Chu, C. Int. Immunopharmacol. (2006) [Pubmed]
  4. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Yamaguchi, Y., Mann, D.M., Ruoslahti, E. Nature (1990) [Pubmed]
  5. Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons. Ezura, Y., Chakravarti, S., Oldberg, A., Chervoneva, I., Birk, D.E. J. Cell Biol. (2000) [Pubmed]
  6. Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint. Säämänen, A.M., Salminen, H.J., Rantakokko, A.J., Heinegård, D., Vuorio, E.I. Biochem. J. (2001) [Pubmed]
  7. Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia. Paluru, P.C., Scavello, G.S., Ganter, W.R., Young, T.L. Mol. Vis. (2004) [Pubmed]
  8. Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. Schönherr, E., Sunderkötter, C., Schaefer, L., Thanos, S., Grässel, S., Oldberg, A., Iozzo, R.V., Young, M.F., Kresse, H. J. Vasc. Res. (2004) [Pubmed]
  9. Functions of lumican and fibromodulin: lessons from knockout mice. Chakravarti, S. Glycoconj. J. (2002) [Pubmed]
  10. Uronic acid-containing glycosaminoglycans and keratan sulfate are present in the tectorial membrane of the inner ear: functional implications. Thalmann, I., Machiki, K., Calabro, A., Hascall, V.C., Thalmann, R. Arch. Biochem. Biophys. (1993) [Pubmed]
  11. Neuropharmacological studies on Fusarium toxins--I: Total toxin extract from Fusarium moniliforme. Ganguli, S., Hota, D., Goel, R.K., Acharya, S.B., Bhattacharya, S.K. Indian J. Exp. Biol. (1996) [Pubmed]
  12. Functional and molecular alterations of the glomerular barrier in long-term diabetes in mice. Jeansson, M., Granqvist, A.B., Nyström, J.S., Haraldsson, B. Diabetologia (2006) [Pubmed]
  13. Distribution of cartilage molecules in the developing mouse joint. Murphy, J.M., Heinegård, R., McIntosh, A., Sterchi, D., Barry, F.P. Matrix Biol. (1999) [Pubmed]
  14. Differential injury responses in oral mucosal and cutaneous wounds. Szpaderska, A.M., Zuckerman, J.D., DiPietro, L.A. J. Dent. Res. (2003) [Pubmed]
  15. Fibromodulin-deficient Mice Display Impaired Collagen Fibrillogenesis in Predentin as Well as Altered Dentin Mineralization and Enamel Formation. Goldberg, M., Septier, D., Oldberg, A., Young, M.F., Ameye, L.G. J. Histochem. Cytochem. (2006) [Pubmed]
  16. Accelerated osteoarthritis in the temporomandibular joint of biglycan/fibromodulin double-deficient mice. Wadhwa, S., Embree, M.C., Kilts, T., Young, M.F., Ameye, L.G. Osteoarthr. Cartil. (2005) [Pubmed]
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