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Gene Review

CNTFR  -  ciliary neurotrophic factor receptor

Gallus gallus

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High impact information on CNTFR


Biological context of CNTFR


Anatomical context of CNTFR


Regulatory relationships of CNTFR

  • As shown immunocytochemically, CNTFR alpha expression in the presumptive photoreceptor layer of the chick retina starts at embryonic day 8 (E8) and is rapidly down-regulated a few days later prior to the differentiation of opsin-positive photoreceptors, both in vivo and in dissociated cultures from E8 [4].

Analytical, diagnostic and therapeutic context of CNTFR


  1. Ciliary neurotrophic factor promotes chick photoreceptor development in vitro. Fuhrmann, S., Kirsch, M., Hofmann, H.D. Development (1995) [Pubmed]
  2. Expression of CNTF receptor-alpha in chick violet-sensitive cones with unique morphologic properties. Seydewitz, V., Rothermel, A., Fuhrmann, S., Schneider, A., DeGrip, W.J., Layer, P.G., Hofmann, H.D. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  3. Cloning of the alpha component of the chick ciliary neurotrophic factor receptor: developmental expression and down-regulation in denervated skeletal muscle. Ip, F.C., Fu, A.K., Tsim, K.W., Ip, N.Y. J. Neurochem. (1995) [Pubmed]
  4. A transient role for ciliary neurotrophic factor in chick photoreceptor development. Fuhrmann, S., Heller, S., Rohrer, H., Hofmann, H.D. J. Neurobiol. (1998) [Pubmed]
  5. Retinoic acid up-regulates ciliary neurotrophic factor receptors in cultured chick neurons and cardiomyocytes. Wang, X., Halvorsen, S.W. Neurosci. Lett. (1998) [Pubmed]
  6. Distribution of CNTF receptor alpha protein in the central nervous system of the chick embryo. Fuhrmann, S., Grabosch, K., Kirsch, M., Hofmann, H.D. J. Comp. Neurol. (2003) [Pubmed]
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