Gene Review:
CNTFR - ciliary neurotrophic factor receptor
Homo sapiens
Synonyms:
CNTF receptor subunit alpha, CNTFR-alpha, Ciliary neurotrophic factor receptor subunit alpha
- The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. Plun-Favreau, H., Elson, G., Chabbert, M., Froger, J., deLapeyrière, O., Lelièvre, E., Guillet, C., Hermann, J., Gauchat, J.F., Gascan, H., Chevalier, S. EMBO J. (2001)
- Protective effect of ciliary neurotrophic factor (CNTF) in a model of endotoxic shock: action mechanisms and role of CNTF receptor alpha. Demitri, M.T., Benigni, F., Meazza, C., Zinetti, M., Fratelli, M., Villa, P., Acheson, A., Panayotatos, N., Ghezzi, P. J. Inflamm. (1998)
- Ciliary neurotrophic factor receptor expression in spinal cord and motor cortex in amyotrophic lateral sclerosis. Duberley, R.M., Johnson, I.P., Anand, P., Swash, M., Martin, J., Leigh, P.N., Zeman, S. J. Neurol. Sci. (1995)
- A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. Devergne, O., Hummel, M., Koeppen, H., Le Beau, M.M., Nathanson, E.C., Kieff, E., Birkenbach, M. J. Virol. (1996)
- Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. Man, D., He, W., Sze, K.H., Gong, K., Smith, D.K., Zhu, G., Ip, N.Y. J. Biol. Chem. (2003)
- Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. DeChiara, T.M., Vejsada, R., Poueymirou, W.T., Acheson, A., Suri, C., Conover, J.C., Friedman, B., McClain, J., Pan, L., Stahl, N., Ip, N.Y., Yancopoulos, G.D. Cell (1995)
- LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Davis, S., Aldrich, T.H., Stahl, N., Pan, L., Taga, T., Kishimoto, T., Ip, N.Y., Yancopoulos, G.D. Science (1993)
- Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses. Davis, S., Aldrich, T.H., Ip, N.Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P.S., Curtis, R., Panayotatos, N., Gascan, H. Science (1993)
- The receptor for ciliary neurotrophic factor. Davis, S., Aldrich, T.H., Valenzuela, D.M., Wong, V.V., Furth, M.E., Squinto, S.P., Yancopoulos, G.D. Science (1991)
- Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor. Valenzuela, D.M., Rojas, E., Le Beau, M.M., Espinosa, R., Brannan, C.I., McClain, J., Masiakowski, P., Ip, N.Y., Copeland, N.G., Jenkins, N.A. Genomics (1995)
- Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists. Di Marco, A., Gloaguen, I., Graziani, R., Paonessa, G., Saggio, I., Hudson, K.R., Laufer, R. Proc. Natl. Acad. Sci. U.S.A. (1996)
- C174T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women. Roth, S.M., Metter, E.J., Lee, M.R., Hurley, B.F., Ferrell, R.E. J. Appl. Physiol. (2003)
- The ciliary neurotrophic factor and its receptor, CNTFR alpha. Sleeman, M.W., Anderson, K.D., Lambert, P.D., Yancopoulos, G.D., Wiegand, S.J. Pharmaceutica acta Helvetiae. (2000)
- Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9. Donaldson, D.H., Britt, D.E., Jones, C., Jackson, C.L., Patterson, D. Genomics (1993)
- The molecular biology of the CNTF receptor. Davis, S., Yancopoulos, G.D. Curr. Opin. Cell Biol. (1993)
- Reciprocal regulation of ciliary neurotrophic factor receptors and acetylcholine receptors during synaptogenesis in embryonic chick atria. Wang, X., Halvorsen, S.W. J. Neurosci. (1998)
- Ciliary neurotrophic factor combined with soluble receptor inhibits synthesis of proinflammatory cytokines and prostaglandin-E2 in vitro. Shapiro, L., Panayotatos, N., Meydani, S.N., Wu, D., Dinarello, C.A. Exp. Cell Res. (1994)
- Opposing regulation of ciliary neurotrophic factor receptors on neuroblastoma cells by distinct differentiating agents. Malek, R.L., Halvorsen, S.W. J. Neurobiol. (1997)
- The tails of two proteins: the scrapie prion protein and the ciliary neurotrophic factor receptor. Stahl, N., Boulton, T.G., Ip, N., Davis, S., Yancopoulos, G.D. Braz. J. Med. Biol. Res. (1994)
- CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction. Saggio, I., Gloaguen, I., Poiana, G., Laufer, R. EMBO J. (1995)
- Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor. Di Marco, A., Gloaguen, I., Demartis, A., Saggio, I., Graziani, R., Paonessa, G., Laufer, R. J. Biol. Chem. (1997)
- Human ciliary neurotrophic factor: a structure-function analysis. Krüttgen, A., Grötzinger, J., Kurapkat, G., Weis, J., Simon, R., Thier, M., Schröder, M., Heinrich, P., Wollmer, A., Comeau, M. Biochem. J. (1995)
- Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. Rousseau, F., Gauchat, J.F., McLeod, J.G., Chevalier, S., Guillet, C., Guilhot, F., Cognet, I., Froger, J., Hahn, A.F., Knappskog, P.M., Gascan, H., Boman, H. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor. Guillet, C., Lelièvre, E., Plun-Favreau, H., Froger, J., Chabbert, M., Hermann, J., Benoit de Coignac, A., Bonnefoy, J.Y., Gascan, H., Gauchat, J.F., Elson, G. Eur. J. Biochem. (2002)
- Expression of functional ciliary neurotrophic factor receptors in immortalized gonadotrophin-releasing hormone-secreting neurones. Dozio, E., Watanobe, H., Ruscica, M., Maggi, R., Motta, M., Magni, P. J. Neuroendocrinol. (2005)
- CNTF and its receptor subunits in human gliomas. Weis, J., Schönrock, L.M., Züchner, S.L., Lie, D.C., Sure, U., Schul, C., Stögbauer, F., Ringelstein, E.B., Halfter, H. J. Neurooncol. (1999)
- Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3. Auernhammer, C.J., Isele, N.B., Kopp, F.B., Spoettl, G., Cengic, N., Weber, M.M., Senaldi, G., Engelhardt, D. Endocrinology (2003)