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Gene Review

ACO  -  acyl-CoA oxidase

Sus scrofa

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Disease relevance of ACO


High impact information on ACO

  • As part of an effort to understand how proteins are imported into the peroxisome, we have sought to identify the peroxisomal targeting signals in four unrelated peroxisomal proteins: human catalase, rat hydratase:dehydrogenase, pig D-amino acid oxidase, and rat acyl-CoA oxidase [2].
  • Blot analysis of RNA from livers of rats treated with a peroxisome proliferator showed 2- to 3-fold increase in UOxase mRNA content, whereas the fatty acyl-CoA oxidase mRNA increased over 30-fold [3].
  • Morris cells responded to the addition of ciprofibrate by increasing the levels of ACO mRNA, whereas HepG2 did not [4].
  • A range of 4-thiaacyl-CoA derivatives has been synthesized to study the bioactivation of cytotoxic fatty acids by the mitochondrial medium-chain acyl-CoA dehydrogenase and the peroxisomal acyl-CoA oxidase [5].
  • Activities of catalase, acyl-CoA oxidase and the cyanide-insensitive acyl-CoA beta-oxidation system in this tissue were comparable with those in rat liver [6].

Biological context of ACO


Anatomical context of ACO


Associations of ACO with chemical compounds


Analytical, diagnostic and therapeutic context of ACO


  1. Photoaffinity labeling of acyl-CoA oxidase with 12-azidooleoyl-CoA and 12-[(4-azidosalicyl)amino]dodecanoyl-CoA. Rajasekharan, R., Marians, R.C., Shockey, J.M., Kemp, J.D. Biochemistry (1993) [Pubmed]
  2. Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins. Gould, S.J., Keller, G.A., Subramani, S. J. Cell Biol. (1988) [Pubmed]
  3. Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat. Reddy, P.G., Nemali, M.R., Reddy, M.K., Reddy, M.N., Yuan, P.M., Yuen, S., Laffler, T.G., Shiroza, T., Kuramitsu, H.K., Usuda, N. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  4. Differences in the formation of PPARalpha-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration. Rodríguez, C., Noé, V., Cabrero, A., Ciudad, C.J., Laguna, J.C. Mol. Pharmacol. (2000) [Pubmed]
  5. Elimination reactions in the medium-chain acyl-CoA dehydrogenase: bioactivation of cytotoxic 4-thiaalkanoic acids. Baker-Malcolm, J.F., Haeffner-Gormley, L., Wang, L., Anders, M.W., Thorpe, C. Biochemistry (1998) [Pubmed]
  6. Participation of peroxisomes in lipid biosynthesis in the harderian gland of guinea pig. Horie, S., Suga, T. Biochem. J. (1989) [Pubmed]
  7. Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression. Hasmall, S.C., James, N.H., Macdonald, N., Soames, A.R., Roberts, R.A. Arch. Toxicol. (2000) [Pubmed]
  8. Expression of turkey transcription factors and acyl-coenzyme oxidase in different tissues and genetic populations. Ding, S.T., Li, Y.C., Nestor, K.E., Velleman, S.G., Mersmann, H.J. Poult. Sci. (2003) [Pubmed]
  9. Expression of porcine transcription factors and genes related to fatty acid metabolism in different tissues and genetic populations. Ding, S.T., Schinckel, A.P., Weber, T.E., Mersmann, H.J. J. Anim. Sci. (2000) [Pubmed]
  10. Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha. Roberts, R.A., James, N.H., Hasmall, S.C., Holden, P.R., Lambe, K., Macdonald, N., West, D., Woodyatt, N.J., Whitcome, D. Toxicol. Lett. (2000) [Pubmed]
  11. Addition of peroxisome proliferator-activated receptor alpha to guinea pig hepatocytes confers increased responsiveness to peroxisome proliferators. Macdonald, N., Holden, P.R., Roberts, R.A. Cancer Res. (1999) [Pubmed]
  12. Biochemical properties of liver peroxisomes from rat, guinea pig and human species and the influence of hormonal status on rat liver acyl-CoA oxidase mRNA content. Pacot, C., Latruffe, N. Biochimie (1993) [Pubmed]
  13. The organelles containing porcine 17 beta-estradiol dehydrogenase are peroxisomes. Markus, M., Husen, B., Leenders, F., Jungblut, P.W., Hall, P.F., Adamski, J. Eur. J. Cell Biol. (1995) [Pubmed]
  14. Peroxisome distribution along the crypt-villus axis of the guinea pig small intestine. Phipps, A.N., Connock, M.J., Johnson, P., Burdett, K. Mol. Cell. Biochem. (2000) [Pubmed]
  15. Difference between guinea pig and rat in the liver peroxisomal response to equivalent plasmatic level of ciprofibrate. Pacot, C., Petit, M., Rollin, M., Behechti, N., Moisant, M., Deslex, P., Althoff, J., Lhuguenot, J.C., Latruffe, N. Arch. Biochem. Biophys. (1996) [Pubmed]
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