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Gene Review

B2M  -  beta-2-microglobulin

Sus scrofa

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High impact information on B2M

  • Antibodies eluted from platelets lysed all lymphocyte populations and precipitated only the 42,000 and 11,000 dalton peaks, indicating that these molecules represent the analogue of murine H-2 histocompatibility antigens, containing a heavy chain and putative swine beta2-microglobulin [1].
  • IgG is a ligand for the Fc receptor FcRn, and beta2-microglobulin, the light chain of FcRn, coclustered in immunogold double labeling with IgG in subapical endosomes and in the basolateral membrane of enterocytes [2].
  • Quantitation of porcine cytokine and beta 2-microglobulin mRNA expression by reverse transcription polymerase chain reaction [3].
  • The method utilized an internal control with primer sequences for interleukin (IL)-1alpha, 2, 4, 6, 8, 10, tumor necrosis factor (TNF)-alpha, TNF-beta, interferon (IFN)-gamma and beta-2 microglobulin (beta(2)-m) [3].
  • The antigen was visualized at the ultrastructural level by immunocytochemical techniques using peroxidase or colloidal gold particles as labels. beta 2m expression appeared to parallel trophoblast differentiation [4].

Biological context of B2M


Anatomical context of B2M


Analytical, diagnostic and therapeutic context of B2M


  1. Transplantation in minature swine. IV. Chemical characterization of MSLA and Ia-like antigens. Lunney, J.K., Sachs, D.H. J. Immunol. (1978) [Pubmed]
  2. Antibodies in the small intestine: mucosal synthesis and deposition of anti-glycosyl IgA, IgM, and IgG in the enterocyte brush border. Hansen, G.H., Niels-Christiansen, L.L., Immerdal, L., Danielsen, E.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  3. Quantitation of porcine cytokine and beta 2-microglobulin mRNA expression by reverse transcription polymerase chain reaction. Reddy, N.R., Wilkie, B.N. J. Immunol. Methods (2000) [Pubmed]
  4. Expression of beta 2-microglobulin on preimplantation pig embryos. Meziou, W., Chardon, P., Fléchon, J.E., Kalil, J., Vaiman, M. J. Reprod. Immunol. (1983) [Pubmed]
  5. Renal circulation and cellular metabolism during left ventricular assisted circulation: comparison study of pulsatile and nonpulsatile assists. Sezai, A., Shiono, M., Orime, Y., Nakata, K., Hata, M., Yamada, H., Iida, M., Kashiwazaki, S., Kinishita, J., Nemoto, M., Koujima, T., Sezai, Y., Saitoh, T. Artificial organs. (1997) [Pubmed]
  6. Extracorporeal hybridization of proximal renal tubular cells and an artificial membrane for the purpose of beta 2 microglobulin removal. Sanaka, T., Agishi, T., Hayashi, T., Hayasaka, Y., Yasuo, M., Fukui, K., Ota, K., Sugino, N. ASAIO transactions / American Society for Artificial Internal Organs. (1989) [Pubmed]
  7. Fractionation and identification of pig lymph node plasma membrane glycoproteins. Barber, B.H., Arya, S. Mol. Immunol. (1982) [Pubmed]
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