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Chemical Compound Review

AGN-PC-00Q3V3     propane-1,1,2-triol

Synonyms: CTK1I2081, AC1L9N5Z, 65687-54-9, 1,1,2-Propanetriol, Propane-1,1,2-triol
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Disease relevance of Pyruvic acid


High impact information on Pyruvic acid


Chemical compound and disease context of Pyruvic acid


Biological context of Pyruvic acid


Anatomical context of Pyruvic acid


Associations of Pyruvic acid with other chemical compounds

  • Treatment of the modified form with 2,4-dinitrophenylhydrazine in acid medium led to the expected hydrazone of pyruvic acid, which was identified by high pressure liquid chromatography [3].
  • To determine the absolute values of the molar absorptivities, we performed the glutamate dehydrogenase or lactate dehydrogenase assay with carefully purified 2-oxoglutaric acid or pyruvic acid in the presence of excess coenzyme [22].
  • The isotopic enrichments of free amino acids in venous plasma and in VLDL apolipoprotein B-100 (apoB)-bound amino acids, plasma alpha-keto isocaproic acid (alpha-KIC) and plasma pyruvic acid (PYR) were measured by negative chemical ionization gas chromatography-mass spectrometry [23].
  • A 27-kDa TASP protein, T(5)Msc(103-151), that was derived from the cytoplasmic domain (amino acid residues 103-151) of the MscL ion channel of M. tuberculosis was synthesized by ketoxime-forming chemoselective ligation between a template molecule carrying five pyruvic acid groups, and linear channel peptides carrying one aminooxyacetic acid group [24].
  • Independently, an X-ray crystal structure of active tryptase tetramer complexed with 4-amidinophenyl pyruvic acid has been reported [25].

Gene context of Pyruvic acid

  • However, prolonged incubation of the siderophore-deficient S. typhimurium strain enb-7 under conditions of high iron stress resulted in significant delayed bacterial growth, promoted by tonB-dependent uptake of iron complexed with the high accumulated levels of pyruvic acid and other alpha-keto acids [26].
  • In view of this finding, we recommend that tests to characterize patients with COMA should include determination of blood levels of lactic and pyruvic acid [27].
  • Results are unaffected by the presence of endogenous serum ADP, pyruvic acid, phosphatases, or ATPase [28].
  • In this study, we investigated the effect of pyruvic acid against 6-OHDA, MPP+ and H(2)0(2) toxicity in murine brain neuroblastoma cells [9].
  • The pyruvic acid was further oxidized with PyOx via the D-AAOx reaction [29].

Analytical, diagnostic and therapeutic context of Pyruvic acid


  1. Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. Lee, M.S., Moon, E.J., Lee, S.W., Kim, M.S., Kim, K.W., Kim, Y.J. Cancer Res. (2001) [Pubmed]
  2. Regulation of lactate production and utilization in rat tumors in vivo. Sauer, L.A., Dauchy, R.T. J. Biol. Chem. (1985) [Pubmed]
  3. Pyruvic acid is attached through its central carbon atom to the amino terminus of the recombinant DNA-derived DNA-binding protein Ner of bacteriophage Mu. Rose, K., Simona, M.G., Savoy, L.A., Regamey, P.O., Green, B.N., Clore, G.M., Gronenborn, A.M., Wingfield, P.T. J. Biol. Chem. (1992) [Pubmed]
  4. Biosynthesis of vitamin B(6) in yeast: incorporation pattern of glucose. Gupta, R.N., Hemscheidt, T., Sayer, B.G., Spenser, I.D. J. Am. Chem. Soc. (2001) [Pubmed]
  5. Antimicrobial susceptibility testing of Bilophila wadsworthia isolates submitted for routine laboratory examination. Mochida, C., Hirakata, Y., Matsuda, J., Iori, F., Ozaki, Y., Nakano, M., Hamaguchi, K., Izumikawa, K., Yamaguchi, T., Tomono, K., Maesaki, S., Yamada, Y., Kohno, S., Kamihira, S. J. Clin. Microbiol. (1998) [Pubmed]
  6. Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Pereira, P.J., Bergner, A., Macedo-Ribeiro, S., Huber, R., Matschiner, G., Fritz, H., Sommerhoff, C.P., Bode, W. Nature (1998) [Pubmed]
  7. Improved medium for selective isolation and enumeration of Bifidobacterium. Tanaka, R., Mutai, M. Appl. Environ. Microbiol. (1980) [Pubmed]
  8. Plasma lactic acid and pyruvic acid levels in migraine and tension-type headache. Okada, H., Araga, S., Takeshima, T., Nakashima, K. Headache. (1998) [Pubmed]
  9. Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro. Mazzio, E., Soliman, K.F. Neurosci. Lett. (2003) [Pubmed]
  10. Oxaloacetate decarboxylase from Pseudomonas stutzeri: purification and characterization. Labrou, N.E., Clonis, Y.D. Arch. Biochem. Biophys. (1999) [Pubmed]
  11. Incorporation of specifically labeled cysteine into Escherichia coli protein. Beilan, H.S., Kenyon, G.L., Browne, D.T. Anal. Biochem. (1983) [Pubmed]
  12. Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell. Zawalich, W.S., Zawalich, K.C. J. Biol. Chem. (1997) [Pubmed]
  13. Structure and synthesis of histopine, a histidine derivative produced by crown gall tumors. Bates, H.A., Kaushal, A., Deng, P.N., Sciaky, D. Biochemistry (1984) [Pubmed]
  14. Sequences and expression of pyruvate dehydrogenase genes from Pseudomonas aeruginosa. Rae, J.L., Cutfield, J.F., Lamont, I.L. J. Bacteriol. (1997) [Pubmed]
  15. Carbon isotope effect of the enzymatic decarboxylation of pyruvic acid. O'Leary, M.H. Biochem. Biophys. Res. Commun. (1976) [Pubmed]
  16. Selective high-performance liquid chromatographic assays for hydralazine and its metabolites in plasma of man. Reece, P.A., Cozamanis, I., Zacest, R. J. Chromatogr. (1980) [Pubmed]
  17. Regional kinetic constants for blood-brain barrier pyruvic acid transport in conscious rats by the monocarboxylic acid carrier. Miller, L.P., Oldendorf, W.H. J. Neurochem. (1986) [Pubmed]
  18. Functional characteristics of H+ -dependent nicotinate transport in primary cultures of astrocytes from rat cerebral cortex. Shimada, A., Nakagawa, Y., Morishige, H., Yamamoto, A., Fujita, T. Neurosci. Lett. (2006) [Pubmed]
  19. Clinical and radiologic improvements in mitochondrial encephalomyelopathy following sodium dichloroacetate therapy. Kimura, S., Ohtuki, N., Nezu, A., Tanaka, M., Takeshita, S. Brain Dev. (1997) [Pubmed]
  20. Glutaric aciduria type II: report on a previously undescribed metabolic disorder. Przyrembel, H., Wendel, U., Becker, K., Bremer, H.J., Bruinvis, L., Ketting, D., Wadman, S.K. Clin. Chim. Acta (1976) [Pubmed]
  21. Dietary addition of cellular metabolic intermediates and carcass fat deposition in broilers. Lessard, P., Lefrançois, M.R., Bernier, J.F. Poult. Sci. (1993) [Pubmed]
  22. Molar absorptivities of beta-NADH and beta-NADPH. Ziegenhorn, J., Senn, M., Bücher, T. Clin. Chem. (1976) [Pubmed]
  23. VLDL apolipoprotein B-100, a potential indicator of the isotopic labeling of the hepatic protein synthetic precursor pool in humans: studies with multiple stable isotopically labeled amino acids. Reeds, P.J., Hachey, D.L., Patterson, B.W., Motil, K.J., Klein, P.D. J. Nutr. (1992) [Pubmed]
  24. Total chemical synthesis of a 27 kDa TASP protein derived from the MscL ion channel of M. tuberculosis by ketoxime-forming ligation. Kochendoerfer, G.G., Tack, J.M., Cressman, S. Bioconjug. Chem. (2002) [Pubmed]
  25. Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Rice, K.D., Tanaka, R.D., Katz, B.A., Numerof, R.P., Moore, W.R. Curr. Pharm. Des. (1998) [Pubmed]
  26. Iron-regulated excretion of alpha-keto acids by Salmonella typhimurium. Reissbrodt, R., Kingsley, R., Rabsch, W., Beer, W., Roberts, M., Williams, P.H. J. Bacteriol. (1997) [Pubmed]
  27. Congenital ocular motor apraxia associated with myopathy, external hydrocephalus and NADH dehydrogenase deficiency. Puñal, J.E., Rodríguez, E., Pintos, E., Campos, Y., Castro-Gago, M. Brain Dev. (1998) [Pubmed]
  28. Ultraviolet spectrometry of serum triglycerides by a totally enzymic method adapted to a centrifugal analyzer. Wakayama, J.E., Swanson, J.R. Clin. Chem. (1977) [Pubmed]
  29. Development of a D-alanine sensor for the monitoring of a fermentation using the improved selectivity by the combination of D-amino acid oxidase and pyruvate oxidase. Inaba, Y., Mizukami, K., Hamada-Sato, N., Kobayashi, T., Imada, C., Watanabe, E. Biosensors & bioelectronics. (2003) [Pubmed]
  30. Structure of the human adult hemoglobin minor fraction A1b by electrospray and secondary ion mass spectrometry. Pyruvic acid as amino-terminal blocking group. Prome, D., Blouquit, Y., Ponthus, C., Prome, J.C., Rosa, J. J. Biol. Chem. (1991) [Pubmed]
  31. Organic acid excretion by Streptomyces lividans TK24 during growth on defined carbon and nitrogen sources. Madden, T., Ward, J.M., Ison, A.P. Microbiology (Reading, Engl.) (1996) [Pubmed]
  32. Use of p-aminophenyl D and L-lactic acids and p-aminophenyl pyruvic acid as effectors in the affinity chromatography of lactate dehydrogenase. Brown, E., Joyeau, R. Biochimie (1979) [Pubmed]
  33. Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel. Berardesca, E., Cameli, N., Primavera, G., Carrera, M. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2006) [Pubmed]
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