The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cysK  -  cysteine synthase A

Escherichia coli UTI89

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cysK


High impact information on cysK


Biological context of cysK

  • Gel mobility shift assays and DNase I footprinting experiments showed that CysB protein binds to the S. typhimurium cysK promoter at two sites, one, designated CBS-K1, at positions -78 to -39 relative to the major transcription start site, and the other, designated CBS-K2, at positions -115 to -79 [2].
  • The encoded CmbR protein is homologous to the LysR family of regulator proteins and is an activator of the metC-cysK operon [3].
  • Other sulfur sources tested showed no significant effect on metC-cysK gene expression [3].
  • After hydrolysis of the purified protein, amino acid sequences of five peptides were obtained, which permitted the cloning and sequencing of the cysK gene [4].
  • The 3.0-kb HindIII-EcoRI fragment bearing cysK contained two additional ORFs encoding a putative transcriptional regulator and dUTPase [4].


  1. Isolation of Salmonella typhimurium cys genes by transduction with a library of recombinant plasmids packaged in bacteriophage P22HT capsids. Monroe, R.S., Kredich, N.M. J. Bacteriol. (1988) [Pubmed]
  2. In vitro interactions of CysB protein with the cysK and cysJIH promoter regions of Salmonella typhimurium. Monroe, R.S., Ostrowski, J., Hryniewicz, M.M., Kredich, N.M. J. Bacteriol. (1990) [Pubmed]
  3. Regulation of the metC-cysK operon, involved in sulfur metabolism in Lactococcus lactis. Fernández, M., Kleerebezem, M., Kuipers, O.P., Siezen, R.J., van Kranenburg, R. J. Bacteriol. (2002) [Pubmed]
  4. Identification, cloning and characterization of cysK, the gene encoding O-acetylserine (thiol)-lyase from Azospirillum brasilense, which is involved in tellurite resistance. Ramírez, A., Castañeda, M., Xiqui, M.L., Sosa, A., Baca, B.E. FEMS Microbiol. Lett. (2006) [Pubmed]
  5. Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins. Lacourciere, G.M., Levine, R.L., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Conversion of Methionine to Cysteine in Bacillus subtilis and Its Regulation. Hullo, M.F., Auger, S., Soutourina, O., Barzu, O., Yvon, M., Danchin, A., Martin-Verstraete, I. J. Bacteriol. (2007) [Pubmed]
WikiGenes - Universities