The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

polA  -  DNA polymerase I

Escherichia coli UTI89

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of polA


High impact information on polA

  • Possible roles of the P. aeruginosa dinB, polA, and polC gene products in mutagenesis are discussed [3].
  • DNA was integrated into the S. typhimurium chromosome at aroC by transferring the vectors into S. typhimurium polA mutants and allowing homologous recombination to occur between the cloned and chromosomal aroC genes [4].
  • However, mutants with defective excision repair were more susceptible to polA stimulation [2].
  • It was found that polA and polC extracts are deficient in the synthesis of supercoiled plasmid DNA, whereas the polB mutation has not effect [5].


  1. Acid-sensitive mutants of Salmonella typhimurium identified through a dinitrophenol lethal screening strategy. Foster, J.W., Bearson, B. J. Bacteriol. (1994) [Pubmed]
  2. Treatment with DNA-damaging agents increases expression of polA'-'lacZ gene fusions in Escherichia coli K-12. Wandt, G., Kubis, S., Quiñones, A. Mol. Gen. Genet. (1997) [Pubmed]
  3. Role of Pseudomonas aeruginosa dinB-Encoded DNA Polymerase IV in Mutagenesis. Sanders, L.H., Rockel, A., Lu, H., Wozniak, D.J., Sutton, M.D. J. Bacteriol. (2006) [Pubmed]
  4. Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains. Strugnell, R.A., Maskell, D., Fairweather, N., Pickard, D., Cockayne, A., Penn, C., Dougan, G. Gene (1990) [Pubmed]
  5. REPLICAtion of small plasmids in extracts of Escherichia coli: requirement for both DNA polymerases I and II. Staudenbauer, W.L. Mol. Gen. Genet. (1976) [Pubmed]
WikiGenes - Universities