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Gene Review:

polA - DNA polymerase I

Escherichia coli UTI89

Staudenbauer, W.L., Strugnell, R.A. et al., Sanders, L.H. et al., Wandt, G. et al., Foster, J.W. et al.

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Disease relevance of polA

The mutation in atrC caused extreme UV light sensitivity and proved to occur within the polA (DNA polymerase I) locus [1].
The polA gene of Escherichia coli encodes the DNA polymerase I that is involved in DNA replication and repair [2].

High impact information on polA

Possible roles of the P. aeruginosa dinB, polA, and polC gene products in mutagenesis are discussed [3].
DNA was integrated into the S. typhimurium chromosome at aroC by transferring the vectors into S. typhimurium polA mutants and allowing homologous recombination to occur between the cloned and chromosomal aroC genes [4].
However, mutants with defective excision repair were more susceptible to polA stimulation [2].
It was found that polA and polC extracts are deficient in the synthesis of supercoiled plasmid DNA, whereas the polB mutation has not effect [5].

References

Acid-sensitive mutants of Salmonella typhimurium identified through a dinitrophenol lethal screening strategy. Foster, J.W., Bearson, B. J. Bacteriol. (1994) [Pubmed]
Treatment with DNA-damaging agents increases expression of polA'-'lacZ gene fusions in Escherichia coli K-12. Wandt, G., Kubis, S., Quiñones, A. Mol. Gen. Genet. (1997) [Pubmed]
Role of Pseudomonas aeruginosa dinB-Encoded DNA Polymerase IV in Mutagenesis. Sanders, L.H., Rockel, A., Lu, H., Wozniak, D.J., Sutton, M.D. J. Bacteriol. (2006) [Pubmed]
Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains. Strugnell, R.A., Maskell, D., Fairweather, N., Pickard, D., Cockayne, A., Penn, C., Dougan, G. Gene (1990) [Pubmed]
REPLICAtion of small plasmids in extracts of Escherichia coli: requirement for both DNA polymerases I and II. Staudenbauer, W.L. Mol. Gen. Genet. (1976) [Pubmed]

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