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Gene Review

aroC  -  chorismate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2323, JW2326
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Disease relevance of aroC


High impact information on aroC


Chemical compound and disease context of aroC


Biological context of aroC


Anatomical context of aroC


Associations of aroC with chemical compounds


Other interactions of aroC

  • This observed linkage of the gerC genes with the ndk, aroC and aroB genes has been similarly observed in B. subtilis [2].
  • Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine [18].
  • Genetic mapping studies show that the mutation mepA is located close to aroC (50 min) and the other mutation, mepB, is very close to malE (91 min) on the chromosome [19].
  • DNA was integrated into the S. typhimurium chromosome at aroC by transferring the vectors into S. typhimurium polA mutants and allowing homologous recombination to occur between the cloned and chromosomal aroC genes [10].

Analytical, diagnostic and therapeutic context of aroC


  1. The overexpression, purification and complete amino acid sequence of chorismate synthase from Escherichia coli K12 and its comparison with the enzyme from Neurospora crassa. White, P.J., Millar, G., Coggins, J.R. Biochem. J. (1988) [Pubmed]
  2. Chorismate synthase from Staphylococcus aureus. Horsburgh, M.J., Foster, T.J., Barth, P.T., Coggins, J.R. Microbiology (Reading, Engl.) (1996) [Pubmed]
  3. Chromosomal location of the attachment site for the PA-2 prophage in Escherichia coli K-12. Pugsley, A.P., Littmann-Louth, D., Schnaitman, C.A. J. Virol. (1979) [Pubmed]
  4. Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA. Lowe, D.C., Savidge, T.C., Pickard, D., Eckmann, L., Kagnoff, M.F., Dougan, G., Chatfield, S.N. Infect. Immun. (1999) [Pubmed]
  5. Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models. Foulongne, V., Walravens, K., Bourg, G., Boschiroli, M.L., Godfroid, J., Ramuz, M., O'Callaghan, D. Infect. Immun. (2001) [Pubmed]
  6. Temporally distinct accumulation of transcripts encoding enzymes of the prechorismate pathway in elicitor-treated, cultured tomato cells. Görlach, J., Raesecke, H.R., Rentsch, D., Regenass, M., Roy, P., Zala, M., Keel, C., Boller, T., Amrhein, N., Schmid, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Spectroscopic and kinetic characterization of the bifunctional chorismate synthase from Neurospora crassa: evidence for a common binding site for 5-enolpyruvylshikimate 3-phosphate and NADPH. Kitzing, K., Macheroux, P., Amrhein, N. J. Biol. Chem. (2001) [Pubmed]
  8. Chorismate synthase from the hyperthermophile Thermotoga maritima combines thermostability and increased rigidity with catalytic and spectral properties similar to mesophilic counterparts. Fitzpatrick, T.B., Killer, P., Thomas, R.M., Jelesarov, I., Amrhein, N., Macheroux, P. J. Biol. Chem. (2001) [Pubmed]
  9. Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthase reaction. Osborne, A., Thorneley, R.N., Abell, C., Bornemann, S. J. Biol. Chem. (2000) [Pubmed]
  10. Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains. Strugnell, R.A., Maskell, D., Fairweather, N., Pickard, D., Cockayne, A., Penn, C., Dougan, G. Gene (1990) [Pubmed]
  11. Studies with flavin analogs provide evidence that a protonated reduced FMN is the substrate-induced transient intermediate in the reaction of Escherichia coli chorismate synthase. Macheroux, P., Bornemann, S., Ghisla, S., Thorneley, R.N. J. Biol. Chem. (1996) [Pubmed]
  12. Escherichia coli chorismate synthase catalyzes the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate. Implications for the enzyme mechanism and the antimicrobial action of (6S)-6-fluoroshikimate. Bornemann, S., Ramjee, M.K., Balasubramanian, S., Abell, C., Coggins, J.R., Lowe, D.J., Thorneley, R.N. J. Biol. Chem. (1995) [Pubmed]
  13. Escherichia coli chorismate synthase: a deuterium kinetic-isotope effect under single-turnover and steady-state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved. Bornemann, S., Balasubramanian, S., Coggins, J.R., Abell, C., Lowe, D.J., Thorneley, R.N. Biochem. J. (1995) [Pubmed]
  14. Genetics of ribosomal protein methylation in Escherichia coli. III. Map position of two genes, prmA and prmB, governing methylation of proteins L11 and L3. Colson, C., Lhoest, J., Urlings, C. Mol. Gen. Genet. (1979) [Pubmed]
  15. Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers. Hindle, Z., Chatfield, S.N., Phillimore, J., Bentley, M., Johnson, J., Cosgrove, C.A., Ghaem-Maghami, M., Sexton, A., Khan, M., Brennan, F.R., Everest, P., Wu, T., Pickard, D., Holden, D.W., Dougan, G., Griffin, G.E., House, D., Santangelo, J.D., Khan, S.A., Shea, J.E., Feldman, R.G., Lewis, D.J. Infect. Immun. (2002) [Pubmed]
  16. Subcellular localization and characterization of chorismate synthase in the apicomplexan Plasmodium falciparum. Fitzpatrick, T., Ricken, S., Lanzer, M., Amrhein, N., Macheroux, P., Kappes, B. Mol. Microbiol. (2001) [Pubmed]
  17. Transfer of a gene for sucrose utilization into Escherichia coli K12, and consequent failure of expression of genes for D-serine utilization. Alaeddinoglu, N.G., Charles, H.P. J. Gen. Microbiol. (1979) [Pubmed]
  18. Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine. Chatfield, S.N., Fairweather, N., Charles, I., Pickard, D., Levine, M., Hone, D., Posada, M., Strugnell, R.A., Dougan, G. Vaccine (1992) [Pubmed]
  19. Mutants of Escherichia coli defective in penicillin-insensitive murein DD-endopeptidase. Iida, K., Hirota, Y., Schwarz, U. Mol. Gen. Genet. (1983) [Pubmed]
  20. Molecular cloning and analysis of a cDNA coding for chorismate synthase from the higher plant Corydalis sempervirens Pers. Schaller, A., Schmid, J., Leibinger, U., Amrhein, N. J. Biol. Chem. (1991) [Pubmed]
  21. Binding of the oxidized, reduced, and radical flavin species to chorismate synthase. An investigation by spectrophotometry, fluorimetry, and electron paramagnetic resonance and electron nuclear double resonance spectroscopy. Macheroux, P., Petersen, J., Bornemann, S., Lowe, D.J., Thorneley, R.N. Biochemistry (1996) [Pubmed]
  22. Purification of chorismate synthase from a cell culture of the higher plant Corydalis sempervirens Pers. Schaller, A., Windhofer, V., Amrhein, N. Arch. Biochem. Biophys. (1990) [Pubmed]
  23. Crystallization and preliminary X-ray crystallographic studies of chorismate synthase from Helicobacter pylori. Ahn, H.J., Yang, J.K., Lee, B.I., Yoon, H.J., Kim, H.W., Suh, S.W. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
  24. Saccharomyces cerevisiae chorismate synthase has a flavin reductase activity. Henstrand, J.M., Schaller, A., Braun, M., Amrhein, N., Schmid, J. Mol. Microbiol. (1996) [Pubmed]
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