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Gene Review

fyuA  -  pesticin receptor

Escherichia coli UTI89

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Disease relevance of fyuA

  • Similar to the Stx2e-producing E. coli isolated from humans, which are mainly lacking further virulence factors, genes of an iron uptake system on the high-pathogenicity island (irp2, fyuA) were detected in three ONT:H10 and ONT:H19 strains from healthy pigs [1].
  • Genes fyuA (ferric yersiniabactin uptake) (66.0%) and irp2 (iron-repressible protein) (68.0%), necessary for Yersinia to acquire iron in the mouse infection model, were regularly detected in combination [2].

High impact information on fyuA

  • Stepwise multivariate analysis identified pap, malX, usp, fyuA, and B2 (all of which were positive predictors) and ireA (which was a negative predictor) as significant predictors of killer status [3].
  • Polypeptides encoded by the fyuA gene located on the HPI could be detected by using immunoblot analysis in most of the HPI-positive STEC strains, suggesting the presence of a functional yersiniabactin system [4].
  • Deletions of the juA-irp gene cluster affecting solely the fyuA part of the HPI were identified in 3% of the E. coli strains tested [5].
  • All except one of the 27 isolates tested for genetic virulence markers harbored the same three virulence genes: iutA and fyuA (siderophores), and traT (serum survival factor) [6].
  • However, fyuA-dependent control of Ybt biosynthesis could be bypassed in a fyuA mutant by ingredients of chrome azurol S (CAS) siderophore indicator agar [7].

Biological context of fyuA


  1. Virulence profiles of Shiga toxin 2e-producing Escherichia coli isolated from healthy pig at slaughter. Zweifel, C., Schumacher, S., Beutin, L., Blanco, J., Stephan, R. Vet. Microbiol. (2006) [Pubmed]
  2. Virulence-associated genes in avian pathogenic Escherichia coli (APEC) isolated from internal organs of poultry having died from colibacillosis. Janben, T., Schwarz, C., Preikschat, P., Voss, M., Philipp, H.C., Wieler, L.H. Int. J. Med. Microbiol. (2001) [Pubmed]
  3. Experimental Mouse Lethality of Escherichia coli Isolates, in Relation to Accessory Traits, Phylogenetic Group, and Ecological Source. Johnson, J.R., Clermont, O., Menard, M., Kuskowski, M.A., Picard, B., Denamur, E. J. Infect. Dis. (2006) [Pubmed]
  4. A genomic island, termed high-pathogenicity island, is present in certain non-O157 Shiga toxin-producing Escherichia coli clonal lineages. Karch, H., Schubert, S., Zhang, D., Zhang, W., Schmidt, H., Olschläger, T., Hacker, J. Infect. Immun. (1999) [Pubmed]
  5. Prevalence of the "high-pathogenicity island" of Yersinia species among Escherichia coli strains that are pathogenic to humans. Schubert, S., Rakin, A., Karch, H., Carniel, E., Heesemann, J. Infect. Immun. (1998) [Pubmed]
  6. Spread of Escherichia coli strains with high-level cefotaxime and ceftazidime resistance between the community, long-term care facilities, and hospital institutions. Oteo, J., Navarro, C., Cercenado, E., Delgado-Iribarren, A., Wilhelmi, I., Orden, B., García, C., Miguelañez, S., Pérez-Vázquez, M., García-Cobos, S., Aracil, B., Bautista, V., Campos, J. J. Clin. Microbiol. (2006) [Pubmed]
  7. Functional analysis of yersiniabactin transport genes of Yersinia enterocolitica. Brem, D., Pelludat, C., Rakin, A., Jacobi, C.A., Heesemann, J. Microbiology (Reading, Engl.) (2001) [Pubmed]
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