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Gene Review

rept  -  reptin

Drosophila melanogaster

Synonyms: CG9750, Dmel\CG9750, Drep, Dreptin, Q9V3K3_DROME, ...
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High impact information on rept

  • In Drosophila, Reptin also copurifies with the Polycomb group (PcG) complex PRC1, which maintains genes in a transcriptionally silent state [1].
  • Furthermore, reptin mutants suppress position-effect variegation (PEV), a phenomenon resulting from spreading of heterochromatin [1].
  • Reptin is a subunit of different chromatin-remodeling complexes, including the TIP60 HAT complex [1].
  • Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1 [2].
  • In Xenopus, while transcribed in the same regions early in embryogenesis, pont and rept adopt significantly different patterns afterwards [3].

Biological context of rept


Other interactions of rept

  • Thus, simultaneous expression during development appears to constitute another feature of the evolutionary conservation of pont and rept genes [3].


  1. Drosophila Reptin and Other TIP60 Complex Components Promote Generation of Silent Chromatin. Qi, D., Jin, H., Lilja, T., Mannervik, M. Genetics (2006) [Pubmed]
  2. Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1. Etard, C., Gradl, D., Kunz, M., Eilers, M., Wedlich, D. Mech. Dev. (2005) [Pubmed]
  3. Analysis of paralogous pontin and reptin gene expression during mouse development. Chauvet, S., Usseglio, F., Aragnol, D., Pradel, J. Dev. Genes Evol. (2005) [Pubmed]
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