High impact information on rept

• In Drosophila, Reptin also copurifies with the Polycomb group (PcG) complex PRC1, which maintains genes in a transcriptionally silent state [1].
• Furthermore, reptin mutants suppress position-effect variegation (PEV), a phenomenon resulting from spreading of heterochromatin [1].
• Reptin is a subunit of different chromatin-remodeling complexes, including the TIP60 HAT complex [1].
• Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1 [2].
• In Xenopus, while transcribed in the same regions early in embryogenesis, pont and rept adopt significantly different patterns afterwards [3].

Biological context of rept

• Analysis of paralogous pontin and reptin gene expression during mouse development [3].
• In reptin homozygous mutant cells, a Polycomb response-element-linked reporter gene is derepressed, whereas endogenous homeotic gene expression is not [1].

Other interactions of rept

• Thus, simultaneous expression during development appears to constitute another feature of the evolutionary conservation of pont and rept genes [3].

References