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Gene Review

RUVBL2  -  RuvB-like AAA ATPase 2

Homo sapiens

Synonyms: 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, CGI-46, ECP-51, ...
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High impact information on RUVBL2


Associations of RUVBL2 with chemical compounds

  • On the other hand, HuH7 cells with an overexpression of RUVBL2 grew better in soft agar (P < 0.03), had increased resistance to C2 ceramide-induced apoptosis (P < 0.001), and gave rise to significantly larger tumors when injected into immunodeficient Rag2/gammac mice (P = 0.016) [4].

Biological context of RUVBL2


Anatomical context of RUVBL2


Physical interactions of RUVBL2


Other interactions of RUVBL2


Analytical, diagnostic and therapeutic context of RUVBL2


  1. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a. Kanemaki, M., Kurokawa, Y., Matsu-ura, T., Makino, Y., Masani, A., Okazaki, K., Morishita, T., Tamura, T.A. J. Biol. Chem. (1999) [Pubmed]
  2. Dodecameric Structure and ATPase Activity of the Human TIP48/TIP49 Complex. Puri, T., Wendler, P., Sigala, B., Saibil, H., Tsaneva, I.R. J. Mol. Biol. (2007) [Pubmed]
  3. Relocalization of human chromatin remodeling cofactor TIP48 in mitosis. Sigala, B., Edwards, M., Puri, T., Tsaneva, I.R. Exp. Cell Res. (2005) [Pubmed]
  4. Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma. Rousseau, B., Ménard, L., Haurie, V., Taras, D., Blanc, J.F., Moreau-Gaudry, F., Metzler, P., Hugues, M., Boyault, S., Lemière, S., Canron, X., Costet, P., Cole, M., Balabaud, C., Bioulac-Sage, P., Zucman-Rossi, J., Rosenbaum, J. Hepatology (2007) [Pubmed]
  5. Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins. Salzer, U., Kubicek, M., Prohaska, R. Biochim. Biophys. Acta (1999) [Pubmed]
  6. Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3. Parfait, B., Giovangrandi, Y., Asheuer, M., Laurendeau, I., Olivi, M., Vodovar, N., Vidaud, D., Vidaud, M., Bièche, I. Ann. Genet. (2000) [Pubmed]
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