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Gene Review

Ruvbl2  -  RuvB-like protein 2

Mus musculus

Synonyms: RuvB-like 2, mp47, p47, p47 protein
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High impact information on Ruvbl2

  • T antigen, c-Jun (p39), and c-Jun-related protein (p47) form an immunoprecipitable complex in SV40 immortalized Schwann cell lines, and T antigen and c-Jun bind independently and as a complex to the P0 promoter [1].
  • Nonhemopoietic cells accounted for the expression of STAT1-mediated indoleamine 2, 3-dioxygenase and the p47 GTPase LRG-47, but not inducible NO synthase mRNA [2].
  • We raised polyclonal antibodies against the fusion protein and by indirect immunofluorescence on primary cultures of hepatocytes have demonstrated that p47 is located in the nucleus [3].
  • Ultracentrifugation and gel filtration analyses showed that p47 in the rat liver cytosol fraction exists as large complexes of 697k [4].
  • A 47k protein (p47) in a high-salt buffer extract of a rat liver nuclear matrix fraction was purified by means of a wheat germ agglutinin affinity column, reversed phase HPLC, and SDS-PAGE, and partial amino acid sequences were analyzed [4].

Biological context of Ruvbl2

  • In contrast, staurosporine was a potent inhibitor of both phorbol ester induced p47 phosphorylation in platelet (I50 value = 540 nM) and also CD3 and CD4 down-regulation in T cells (I50 values 200 nM and 50 nM respectively) [5].

Anatomical context of Ruvbl2

  • In this paper, we report the cloning and analysis of a cDNA encoding a protein of M(r) congruent to 47,000 (p47), which is localized to the nucleus of rat hepatocytes [3].
  • We show that the p47 GTPases, including IIGP1, accumulate at vacuoles containing T. gondii [6].
  • Out phoxing the endothelium: what's left without p47 [7]?


  1. SV40 large T antigen with c-Jun down-regulates myelin P0 gene expression: a mechanism for papovaviral T antigen-mediated demyelination. Bharucha, V.A., Peden, K.W., Tennekoon, G.I. Neuron (1994) [Pubmed]
  2. STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells. Rothfuchs, A.G., Trumstedt, C., Mattei, F., Schiavoni, G., Hidmark, A., Wigzell, H., Rottenberg, M.E. J. Immunol. (2006) [Pubmed]
  3. Molecular cloning and analysis of an eIF-4A-related rat liver nuclear protein. Nair, S., Dey, R., Sanford, J.P., Doyle, D. J. Biol. Chem. (1992) [Pubmed]
  4. Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. Gohshi, T., Shimada, M., Kawahire, S., Imai, N., Ichimura, T., Omata, S., Horigome, T. J. Biochem. (1999) [Pubmed]
  5. Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases. Nixon, J.S., Wilkinson, S.E., Davis, P.D., Sedgwick, A.D., Wadsworth, J., Westmacott, D. Agents Actions (1991) [Pubmed]
  6. Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. Martens, S., Parvanova, I., Zerrahn, J., Griffiths, G., Schell, G., Reichmann, G., Howard, J.C. PLoS Pathog. (2005) [Pubmed]
  7. Out phoxing the endothelium: what's left without p47? Lassègue, B., Griendling, K.K. Circ. Res. (2002) [Pubmed]
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