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Gene Review

Su(Tpl)  -  CG32217 gene product from transcript...

Drosophila melanogaster

Synonyms: 0854/01, CG32217, CG8037, CR32216, Dmel\CG32217, ...
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High impact information on Su(Tpl)


Biological context of Su(Tpl)


Analytical, diagnostic and therapeutic context of Su(Tpl)

  • We showed that dELL is expressed mainly in the ovaries and early embryonic stages by developmental Northern blot. dELL encodes a protein of 912 amino acids which is substantially longer than the hELL (612 aa) [5].


  1. Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo. Gerber, M., Ma, J., Dean, K., Eissenberg, J.C., Shilatifard, A. EMBO J. (2001) [Pubmed]
  2. dELL is an essential RNA polymerase II elongation factor with a general role in development. Eissenberg, J.C., Ma, J., Gerber, M.A., Christensen, A., Kennison, J.A., Shilatifard, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Eissenberg, J.C., Shilatifard, A., Dorokhov, N., Michener, D.E. Mol. Genet. Genomics (2007) [Pubmed]
  4. Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster. Gerber, M.A., Shilatifard, A., Eissenberg, J.C. Mol. Cell. Biol. (2005) [Pubmed]
  5. dELL, a drosophila homologue of transcription elongation factor ELL (Eleven-nineteen Lysine rich Leukemia), is required for early development. Khattak, S., Im, H., Park, T., Ahnn, J., Spoerel, N.A. Cell Biochem. Funct. (2002) [Pubmed]
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