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Gene Review

alphaSnap  -  alpha Soluble NSF attachment protein

Drosophila melanogaster

Synonyms: CG6625, Dmel\CG6625, N-ethylmaleimide-sensitive factor attachment protein, SNAP, Snap, ...
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High impact information on Snap


Biological context of Snap


Anatomical context of Snap


Other interactions of Snap

  • The N-ethylmaleimide-sensitive factor (NSF) and soluble NSF attachment protein (SNAP) are cytosolic factors that promote vesicle fusion with a target membrane in both the constitutive and regulated secretory pathways [9].

Analytical, diagnostic and therapeutic context of Snap

  • Genetic dissection of the secretory pathway in yeast, identification of the target proteins cleaved by the clostridial neurotoxins and biochemical characterization of the interactions of synaptic proteins from vertebrates have converged to provide the SNARE (soluble NSF attachment protein receptor) hypothesis for vesicle trafficking [10].


  1. Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant. Rao, S.S., Stewart, B.A., Rivlin, P.K., Vilinsky, I., Watson, B.O., Lang, C., Boulianne, G., Salpeter, M.M., Deitcher, D.L. EMBO J. (2001) [Pubmed]
  2. The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation. Suzuki, T., Oiso, N., Gautam, R., Novak, E.K., Panthier, J.J., Suprabha, P.G., Vida, T., Swank, R.T., Spritz, R.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. C2B Polylysine Motif of Synaptotagmin Facilitates a Ca2+-independent Stage of Synaptic Vesicle Priming In Vivo. Loewen, C.A., Lee, S.M., Shin, Y.K., Reist, N.E. Mol. Biol. Cell (2006) [Pubmed]
  4. Functional and molecular identification of novel members of the ubiquitous membrane fusion proteins alpha- and gamma-SNAP (soluble N-ethylmaleimide-sensitive factor-attachment proteins) families in Dictyostelium discoideum. Weidenhaupt, M., Bruckert, F., Louwagie, M., Garin, J., Satre, M. Eur. J. Biochem. (2000) [Pubmed]
  5. Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin. Gorczyca, D., Ashley, J., Speese, S., Gherbesi, N., Thomas, U., Gundelfinger, E., Gramates, L.S., Budnik, V. J. Neurosci. (2007) [Pubmed]
  6. Rolling blackout is required for synaptic vesicle exocytosis. Huang, F.D., Woodruff, E., Mohrmann, R., Broadie, K. J. Neurosci. (2006) [Pubmed]
  7. Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling. Mathew, D., Popescu, A., Budnik, V. J. Neurosci. (2003) [Pubmed]
  8. synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. Littleton, J.T., Bai, J., Vyas, B., Desai, R., Baltus, A.E., Garment, M.B., Carlson, S.D., Ganetzky, B., Chapman, E.R. J. Neurosci. (2001) [Pubmed]
  9. Genetic analysis of soluble N-ethylmaleimide-sensitive factor attachment protein function in Drosophila reveals positive and negative secretory roles. Babcock, M., Macleod, G.T., Leither, J., Pallanck, L. J. Neurosci. (2004) [Pubmed]
  10. Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis. Littleton, J.T., Bellen, H.J. Invert. Neurosci. (1995) [Pubmed]
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