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Gene Review

PTH1R  -  parathyroid hormone 1 receptor

Canis lupus familiaris

Synonyms: PTH1, PTHR1
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Disease relevance of PTHR1


High impact information on PTHR1

  • Infusion of the PTE vehicle alone did not affect PTH receptor number or blunt the adenylate cyclase response to PTH [2].
  • However, PTH receptor binding (125I-norleucyl8-norleucyl18-tyrosinyl34, 125I[Nle8, Nle18, Tyr34] bPTH (1-34) NH2 as radioligand) was not different in the two groups of animals [3].
  • Immunohistochemical and immunoelectron microscopic analysis showed that PTHR protein is expressed on both basolateral and luminal membranes of proximal tubular epithelial cells, strongly suggesting a bipolar mode of action of PTH [4].
  • In addition to expression in vascular endothelial cells, high levels of P1-specific, but not P2-specific, PTHR messenger RNA were detected in vascular smooth muscle [4].
  • We found that both P1 and P2 are expressed at moderate levels in both cortical and medullary epithelial cells of nephrons, correlating well with the immunohistochemical localization of PTHR protein [4].

Biological context of PTHR1

  • Taken together, these experiments provide evidence for strong PTHR gene expression in renal vascular tissues [4].

Anatomical context of PTHR1

  • Membranes isolated under conditions designed to inhibit endogenous proteolysis displayed a major 85K labeled PTH receptor moiety on sodium dodecyl sulfate-polyacrylamide gel electrophoresis [5].
  • Strikingly, immunoelectron microscopic analysis showed that endothelial cells of the peritubular vasculature, but not the glomerular vasculature, contain high levels of PTHR protein [4].
  • The area of calcium physiology has been especially active due to the discovery of a new calcium-regulating hormone, parathyroid hormone-related protein, cloning of the parathyroid hormone receptor and identification of a cell membrane receptor for ionized calcium [6].

Associations of PTHR1 with chemical compounds


Physical interactions of PTHR1

  • These studies also provide further confirmation that PTH and PTHrP bind to a structurally indistinguishable renal receptor and validate the use of PTHrP as a ligand for studies designed to characterize and purify the PTH receptor [10].

Analytical, diagnostic and therapeutic context of PTHR1

  • Here, we have used immunohistochemical and transcript-specific in situ hybridization techniques to map the expression of the PTHR gene and protein and to determine the distribution of P1- and P2-driven messenger RNAs in renal tissue [4].
  • Peptide-mapping experiments revealed the presence within the 85K PTH receptor subunit of at least two major regions sensitive to proteolytic attack [5].


  1. Inhibition of in vitro bone resorption by a parathyroid hormone receptor antagonist in the canine adenocarcinoma model of humoral hypercalcemia of malignancy. Rosol, T.J., Capen, C.C. Endocrinology (1988) [Pubmed]
  2. Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone. Mahoney, C.A., Nissenson, R.A. J. Clin. Invest. (1983) [Pubmed]
  3. Effects of dietary-induced hyperparathyroidism on the parathyroid hormone-receptor-adenylate cyclase system of canine kidney. Evidence for postreceptor mechanism of desensitization. Tamayo, J., Bellorin-Font, E., Martin, K.J. J. Clin. Invest. (1983) [Pubmed]
  4. Cell-specific expression of the parathyroid hormone (PTH)/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promoters. Amizuka, N., Lee, H.S., Kwan, M.Y., Arazani, A., Warshawsky, H., Hendy, G.N., Ozawa, H., White, J.H., Goltzman, D. Endocrinology (1997) [Pubmed]
  5. Structural properties of the renal parathyroid hormone receptor: hydrodynamic analysis and protease sensitivity. Karpf, D.B., Arnaud, C.D., Bambino, T., Duffy, D., King, K.L., Winer, J., Nissenson, R.A. Endocrinology (1988) [Pubmed]
  6. Pathophysiology of calcium, phosphorus, and magnesium metabolism in animals. Rosol, T.J., Capen, C.C. Vet. Clin. North Am. Small Anim. Pract. (1996) [Pubmed]
  7. Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex. Nissenson, R.A., Mann, E., Winer, J., Teitelbaum, A.P., Arnaud, C.D. Endocrinology (1986) [Pubmed]
  8. The canine renal parathyroid hormone receptor is a glycoprotein: characterization and partial purification. Karpf, D.B., Arnaud, C.D., King, K., Bambino, T., Winer, J., Nyiredy, K., Nissenson, R.A. Biochemistry (1987) [Pubmed]
  9. Coupling of the canine renal parathyroid hormone receptor to adenylate cyclase: modulation by guanyl nucleotides and N-ethylmaleimide. Teitelbaum, A.P., Nissenson, R.A., Arnaud, C.D. Endocrinology (1982) [Pubmed]
  10. Features of the renal parathyroid hormone-parathyroid hormone-related protein receptor derived from structural studies of receptor fragments. Karpf, D.B., Bambino, T., Alford, G., Nissenson, R.A. J. Bone Miner. Res. (1991) [Pubmed]
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