The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Vha26  -  Vacuolar H[+]-ATPase 26kD subunit

Drosophila melanogaster

Synonyms: ATP6V1E1, BcDNA.GH03683, BcDNA:GH03683, CG1088, Dmel\CG1088, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Vha26

  • As the ultimate target is the V-ATPase in the apical plasma membrane, this selective activation of mitochondria is clearly adaptive [1].
  • The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase [1].
  • Lethality of these alleles could be reverted by transformation of flies with a wild type vha55::GFP fusion, confirming that the lethal phenotype described for these alleles was due to defects in V-ATPase function [2].
  • One enhancer trap revealed expression of the gene encoding the C subunit of vacuolar ATPase (V-ATPase) in the medial cells of the ring gland, which produce the juvenile hormone that controls progression through developmental stages [3].
  • Molecular genetic analysis of V-ATPase function in Drosophila melanogaster [4].

Biological context of Vha26

  • Involvement of V-ATPase in the regulation of cell size in the fly's visual system [5].
  • The vacuolar H+-ATPase (V-ATPase) is a multisubunit enzyme that couples ATP hydrolysis to proton pumping across membranes [6].

Anatomical context of Vha26

  • While yeast is the model of choice for the rapid generation and identification of V-ATPase mutants, it does not allow their analysis in a plasma membrane context [4].
  • Moreover, vacuolar-type H+-ATPase (V-ATPase) in the optic lobe is thought also to participate in such regulation [5].
  • In the visual systems of both fly species V-ATPase was localized immunocytochemically to the compound eye photoreceptors [5].
  • V-ATPase were detected in various cytoplasmic vesicles and in yolk spheres and, beginning with stage 10, also in apical follicle-cell membranes and in the oolemma [7].
  • Na,K-ATPase and V-ATPase in ovarian follicles of Drosophila melanogaster [7].

Other interactions of Vha26


  1. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Terhzaz, S., Southall, T.D., Lilley, K.S., Kean, L., Allan, A.K., Davies, S.A., Dow, J.A. J. Biol. Chem. (2006) [Pubmed]
  2. The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A., McInerny, C.J., Dow, J.A. J. Cell. Sci. (2006) [Pubmed]
  3. Genes expressed in the ring gland, the major endocrine organ of Drosophila melanogaster. Harvie, P.D., Filippova, M., Bryant, P.J. Genetics (1998) [Pubmed]
  4. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. Dow, J.A., Davies, S.A., Guo, Y., Graham, S., Finbow, M.E., Kaiser, K. J. Exp. Biol. (1997) [Pubmed]
  5. Involvement of V-ATPase in the regulation of cell size in the fly's visual system. Pyza, E., Borycz, J., Giebultowicz, J.M., Meinertzhagen, I.A. J. Insect Physiol. (2004) [Pubmed]
  6. Structural gene organization and evolutionary aspects of the V-ATPase accessory subunit Ac45. Schoonderwoert, V.T., Martens, G.J. Biochim. Biophys. Acta (2002) [Pubmed]
  7. Na,K-ATPase and V-ATPase in ovarian follicles of Drosophila melanogaster. Bohrmann, J., Braun, B. Biol. Cell (1999) [Pubmed]
  8. Characterisation of vha26, the Drosophila gene for a 26 kDa E-subunit of the vacuolar ATPase. Guo, Y., Wang, Z., Carter, A., Kaiser, K., Dow, J.A. Biochim. Biophys. Acta (1996) [Pubmed]
WikiGenes - Universities