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Gene Review

ATP6V1E1  -  ATPase, H+ transporting, lysosomal 31kDa,...

Homo sapiens

Synonyms: ATP6E, ATP6E2, ATP6V1E, P31, V-ATPase 31 kDa subunit, ...
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Disease relevance of ATP6V1E1


High impact information on ATP6V1E1

  • A hepatitis B surface antigen polypeptide (P31) with the receptor for polymerized human as well as chimpanzee albumins [6].
  • The phenotypically normal father and grandfather of the patient each had a small supernumerary ring chromosome and demonstrated three copies for the loci D22S9, D22S43, and ATP6E [7].
  • Levels of total ATP in the quadriceps muscles of the subjects were determined during rest, exercise, and recovery, using noninvasive P-31 magnetic resonance spectroscopy (MRS) [8].
  • Biochemical status was evaluated with P-31 MRS by determining the concentrations of the high-energy phosphate compounds, ATP and phosphocreatine (PCr), ratios of inorganic phosphate (Pi) to PCr (Pi:PCr ratio), levels of free cytosolic ADP, and phosphorylation potentials (PPs) during rest, exercise, and recovery [3].
  • Biochemical status of muscle was evaluated with P-31 MRS by determining concentrations of inorganic phosphate (Pi), phosphocreatine (PCr), ATP, and phosphodiesters during rest and exercise [5].

Chemical compound and disease context of ATP6V1E1


Biological context of ATP6V1E1


Anatomical context of ATP6V1E1

  • Northern blotting analysis demonstrated that ATP6E1 is specifically transcribed in testis as 1.1 kb and 2.2 kb mRNAs, whereas the previously reported ATP6E2 (E2) is expressed in all tissues tested [19].
  • However, CTB labelling also revealed significantly increased motor axon terminals in the ventral Renshaw cell region in BTX-treated animals at P31, accompanied by raised expression of cJun in ipsilateral motoneurones [20].
  • HU also enhanced the differentiation of other myeloid leukaemia HL-60, ML-1, THP-1, P39/TSU, P31/FUJ and NB4 cells induced by 1,25(OH)2D3 and that of U937 cells induced by 24-epi-1,25(OH)2D2 and 1,25(OH)2D7 [21].
  • After posterior tibial nerve stimulation, the following waveforms are recorded: N22, W3, the dorsal column volley, N29, P31, N34, and P37 [22].
  • The growth of two non-T,non-B-cell lines (Reh, P30/OHK) and six myeloid cell lines (ML-1, U937, THP-1-0, P31/FUJ, P39/TSU, HEL) was found to be significantly inhibited by a 72 hr treatment with PAC-4D [23].

Associations of ATP6V1E1 with chemical compounds


Other interactions of ATP6V1E1

  • P31 and P39 showed higher activities for poly-HSA receptor than their glycosylated versions [1].

Analytical, diagnostic and therapeutic context of ATP6V1E1

  • A screen for proteins that bind the V-ATPase E subunit using the yeast two-hybrid assay identified the cDNA clone coded for aldolase, an enzyme of the glycolytic pathway [25].
  • In two breast cancers treated with radiation therapy, resulting in a decrease of tumor volume of more than 50%, a similar change in the tumor P-31 spectrum was observed: An intense PCr signal developed (PCr/ATP = 1.1) [26].
  • As such, P-31 NMR spectroscopy offers a promising method that may enable analysis of the metabolic viability of intact human donor corneas to provide a basis for selecting donor corneas for transplantation [24].
  • Thirteen patients with congestive cardiomyopathy and eight healthy volunteers were imaged at 1.5 T with the one-dimensional chemical shift imaging technique for localization of P-31 MR spectroscopy and an electrocardiographically referenced gradient refocused sequence for imaging of the heart [18].
  • Western blotting analysis has shown that E. coli[pTRP P31-R] synthesizes a specific polypeptide P31 of about 31 kDal, which reacts with anti-HBsAg antibody [10].


  1. Polypeptides coded for by the region pre-S and gene S of hepatitis B virus DNA with the receptor for polymerized human serum albumin: expression on hepatitis B particles produced in the HBeAg or anti-HBe phase of hepatitis B virus infection. Takahashi, K., Kishimoto, S., Ohnuma, H., Machida, A., Takai, E., Tsuda, F., Miyamoto, H., Tanaka, T., Matsushita, K., Oda, K. J. Immunol. (1986) [Pubmed]
  2. Simulation of ATP metabolism in cardiac excitation-contraction coupling. Matsuoka, S., Sarai, N., Jo, H., Noma, A. Prog. Biophys. Mol. Biol. (2004) [Pubmed]
  3. Muscle abnormalities in juvenile dermatomyositis patients: P-31 magnetic resonance spectroscopy studies. Park, J.H., Niermann, K.J., Ryder, N.M., Nelson, A.E., Das, A., Lawton, A.R., Hernanz-Schulman, M., Olsen, N.J. Arthritis Rheum. (2000) [Pubmed]
  4. P-31 magnetic resonance spectroscopy demonstrates unaltered muscle energy utilization in polymyalgia rheumatica. Mattei, J.P., Bendahan, D., Erkintalo, M., Harle, J.R., Weiller, P.J., Roux, H., Cozzone, P.J. Arthritis Rheum. (1997) [Pubmed]
  5. Use of P-31 magnetic resonance spectroscopy to detect metabolic abnormalities in muscles of patients with fibromyalgia. Park, J.H., Phothimat, P., Oates, C.T., Hernanz-Schulman, M., Olsen, N.J. Arthritis Rheum. (1998) [Pubmed]
  6. A hepatitis B surface antigen polypeptide (P31) with the receptor for polymerized human as well as chimpanzee albumins. Machida, A., Kishimoto, S., Ohnuma, H., Miyamoto, H., Baba, K., Oda, K., Nakamura, T., Miyakawa, Y., Mayumi, M. Gastroenterology (1983) [Pubmed]
  7. Minute supernumerary ring chromosome 22 associated with cat eye syndrome: further delineation of the critical region. Mears, A.J., el-Shanti, H., Murray, J.C., McDermid, H.E., Patil, S.R. Am. J. Hum. Genet. (1995) [Pubmed]
  8. Magnesium abnormalities of skeletal muscle in dermatomyositis and juvenile dermatomyositis. Niermann, K.J., Olsen, N.J., Park, J.H. Arthritis Rheum. (2002) [Pubmed]
  9. Assessment of brain death in children by means of P-31 MR spectroscopy: preliminary note. Work in progress. Kato, T., Tokumaru, A., O'uchi, T., Mikami, I., Umeda, M., Nose, K., Eguchi, T., Hasegawa, M., Okuyama, K. Radiology. (1991) [Pubmed]
  10. Expression of hepatitis B virus surface antigen P31 gene in Escherichia coli. Fujisawa, Y., Ito, Y., Ikeyama, S., Kikuchi, M. Gene (1985) [Pubmed]
  11. Bumetanide annihilation of amphotericin B-induced apoptosis and cytotoxicity is due to its effect on cellular K+ flux. Marklund, L., Behnam-Motlagh, P., Henriksson, R., Grankvist, K. J. Antimicrob. Chemother. (2001) [Pubmed]
  12. Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro. Johansson, D., Bergström, P., Henriksson, R., Grankvist, K., Johansson, A., Behnam-Motlagh, P. Oncol. Res. (2006) [Pubmed]
  13. Amphotericin B-induced apoptosis and cytotoxicity is prevented by the Na+, K+, 2Cl(-)-cotransport blocker bumetanide. Marklund, L., Henriksson, R., Grankvist, K. Life Sci. (2000) [Pubmed]
  14. Tibial somatosensory evoked potential intraoperative monitoring: recommendations based on signal to noise ratio analysis of popliteal fossa, optimized P37, standard P37, and P31 potentials. MacDonald, D.B., Al Zayed, Z., Stigsby, B. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2005) [Pubmed]
  15. Monitoring the bioenergetics of cardiac allograft rejection using in vivo P-31 nuclear magnetic resonance spectroscopy. Canby, R.C., Evanochko, W.T., Barrett, L.V., Kirklin, J.K., McGiffin, D.C., Sakai, T.T., Brown, M.E., Foster, R.E., Reeves, R.C., Pohost, G.M. J. Am. Coll. Cardiol. (1987) [Pubmed]
  16. Intriguing conformation changes associated with the trans/cis isomerization of a prolyl residue in the active site of the DsbA C33A mutant. Ondo-Mbele, E., Vivès, C., Koné, A., Serre, L. J. Mol. Biol. (2005) [Pubmed]
  17. Characterization of the interaction of wheat HMGa with linear and four-way junction DNAs. Zhang, W., Wu, Q., Pwee, K.H., Jois, S.D., Kini, R.M. Biochemistry (2003) [Pubmed]
  18. Normal and diffusely abnormal myocardium in humans: functional and metabolic characterization with P-31 MR spectroscopy and cine MR imaging. Auffermann, W., Chew, W.M., Wolfe, C.L., Tavares, N.J., Parmley, W.W., Semelka, R.C., Donnelly, T., Chatterjee, K., Higgins, C.B. Radiology. (1991) [Pubmed]
  19. A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E. Imai-Senga, Y., Sun-Wada, G.H., Wada, Y., Futai, M. Gene (2002) [Pubmed]
  20. The effects of botulinum neurotoxin A induced muscle paresis during a critical period upon muscle and spinal cord development in the rat. Clowry, G.J., Walker, L., Davies, P. Exp. Neurol. (2006) [Pubmed]
  21. Growth inhibition and differentiation induction in human monoblastic leukaemia cells by 1alpha-hydroxyvitamin D derivatives and their enhancement by combination with hydroxyurea. Makishima, M., Okabe-Kado, J., Honma, Y. Br. J. Cancer (1998) [Pubmed]
  22. Generators of short latency human somatosensory-evoked potentials recorded over the spine and scalp. Lee, E.K., Seyal, M. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (1998) [Pubmed]
  23. Potential limitation of growth-inhibitory action of recombinant human tumor necrosis factor (PAC-4D) due to easy induction of resistance: evidence in vitro. Hanada, M., Shimoyama, M. Jpn. J. Cancer Res. (1987) [Pubmed]
  24. Phosphatic metabolites of the intact cornea by phosphorus-31 nuclear magnetic resonance. Greiner, J.V., Kopp, S.J., Gillette, T.E., Glonek, T. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
  25. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. Lu, M., Holliday, L.S., Zhang, L., Dunn, W.A., Gluck, S.L. J. Biol. Chem. (2001) [Pubmed]
  26. Human breast cancer in vivo: H-1 and P-31 MR spectroscopy at 1.5 T. Sijens, P.E., Wijrdeman, H.K., Moerland, M.A., Bakker, C.J., Vermeulen, J.W., Luyten, P.R. Radiology. (1988) [Pubmed]
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