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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

puc  -  puckered

Drosophila melanogaster

Synonyms: 0238/03, 1351/08, CG7850, Dmel\CG7850, JNK-DSP, ...
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High impact information on puc

  • puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila [1].
  • Appropriate dpp and puc expression in the leading edge also depends on the inhibitory function of the puc gene [2].
  • Strikingly, decreased or increased puc function leads to a corresponding increase or decrease, respectively, of Fos and Jun protein levels [3].
  • Phenotypes associated with puc mutant follicle cells include altered DE-cadherin expression in the follicle cells and a failure of nurse cell dumping to coordinate with dorsal appendage elongation, leading to the formation of cup-shaped egg chambers [3].
  • Taken together, these data indicate that puc modulates gene expression responses by antagonizing a Rho GTPase signal transduction pathway that stabilizes the AP-1 transcription factor [3].

Biological context of puc


Anatomical context of puc

  • We show that hep controls the expression of puckered (puc) in the follicular epithelium in a cell-autonomous manner [5].
  • In thorax closure a special row of margin cells express puc and accumulate prominent actin fibres during midline attachment [6].
  • We showed that puc gene expression is induced at the edge of the wound in epithelial cells and Jun kinase is phosphorylated in wounded epidermal tissues, suggesting that the JUN N-terminal kinase signaling pathway is activated by a signal produced by an epidermal wound [4].

Other interactions of puc

  • Since puc overexpression in the egg follicular epithelium mimics JNK appendages and micropyle phenotypes, it indicates a negative role of puc in their morphogenesis [5].
  • Furthermore, we show that the small GTPase Dcdc42, but not Drac1, is an activator of puc expression in a hep-dependent manner in imaginal discs [7].


  1. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Martín-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A.M., Martinez-Arias, A. Genes Dev. (1998) [Pubmed]
  2. Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Glise, B., Noselli, S. Genes Dev. (1997) [Pubmed]
  3. Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis. Dobens, L.L., Martín-Blanco, E., Martínez-Arias, A., Kafatos, F.C., Raftery, L.A. Development (2001) [Pubmed]
  4. JNK signaling pathway is required for efficient wound healing in Drosophila. Rämet, M., Lanot, R., Zachary, D., Manfruelli, P. Dev. Biol. (2002) [Pubmed]
  5. The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Suzanne, M., Perrimon, N., Noselli, S. Dev. Biol. (2001) [Pubmed]
  6. Thorax closure in Drosophila: involvement of Fos and the JNK pathway. Zeitlinger, J., Bohmann, D. Development (1999) [Pubmed]
  7. The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis. Agnès, F., Suzanne, M., Noselli, S. Development (1999) [Pubmed]
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