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Gene Review

Dhod  -  Dihydroorotate dehydrogenase

Drosophila melanogaster

Synonyms: CG9741, DHOD, DHODH, DHOdehase, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
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High impact information on Dhod


Biological context of Dhod

  • Furthermore, Dhod alleles are semidominant in heterozygotes, suggesting that the dosage-sensitive element detected in the trisomics is actually the Dhod locus [5].
  • The effects of alleles of the locus, Dhod, are manifest in preparations from whole organisms as well as in partially purified mitochondrial preparations; however, other mitochondrial functions do not appear to be appreciably affected by Dhod genotypes [5].
  • Mutations at the Dhod locus have been isolated following ethylmethanesulfonate mutagenesis [6].
  • However, r-1 flies also express two phenotypes, mottled eyes and poor viability, that are not usually expressed by r and Dhod-null flies [7].
  • These results are discussed in the contexts of known mechanisms of gene regulation during spermatogenesis and potential roles of DHOdehase during spermiogenesis [4].

Anatomical context of Dhod


Associations of Dhod with chemical compounds


Analytical, diagnostic and therapeutic context of Dhod


  1. Genetic and molecular mapping of chromosome region 85A in Drosophila melanogaster. Jones, W.K., Rawls, J.M. Genetics (1988) [Pubmed]
  2. Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes. Nara, T., Hshimoto, T., Aoki, T. Gene (2000) [Pubmed]
  3. The dhod gene and deduced structure of mitochondrial dihydroorotate dehydrogenase in Drosophila melanogaster. Rawls, J., Kirkpatrick, R., Yang, J., Lacy, L. Gene (1993) [Pubmed]
  4. Expression of the dihydroorotate dehydrogenase gene, dhod, during spermatogenesis in Drosophila melanogaster. Yang, J., Porter, L., Rawls, J. Mol. Gen. Genet. (1995) [Pubmed]
  5. A small genetic region that controls dihydroorotate dehydrogenase in Drosophila melanogaster. Rawls, J.M., Chambers, C.L., Cohen, W.S. Biochem. Genet. (1981) [Pubmed]
  6. The Dhod locus of Drosophila: mutations and interrelationships with other loci controlling de novo pyrimidine biosynthesis. Porter, L.A., Rawls, J.M. Mol. Gen. Genet. (1984) [Pubmed]
  7. Analysis of the phenotypes exhibited by rudimentary-like mutants of Drosophila melanogaster. Conner, T.W., Rawls, J.M. Biochem. Genet. (1982) [Pubmed]
  8. The effects of recessive lethal Notch mutations of Drosophila melanogaster on flavoprotein enzyme activities whose inhibitions cause Notch-like phenocopies. Thörig, G.E., Heinstra, P.W., de Ruiter, B.L., Scharloo, W. Biochem. Genet. (1987) [Pubmed]
  9. Molecular cloning and transcript mapping of the dihydroorotate dehydrogenase dhod locus of Drosophila melanogaster. Jones, W.K., Kirkpatrick, R., Rawls, J.M. Mol. Gen. Genet. (1989) [Pubmed]
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