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Gene Review

MAGEA6  -  melanoma antigen family A, 6

Homo sapiens

Synonyms: CT1.6, Cancer/testis antigen 1.6, MAGE-3b, MAGE-6 antigen, MAGE3B, ...
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Disease relevance of MAGEA6


High impact information on MAGEA6

  • CD4(+) T cell secretion of IL-10 and transforming growth factor (TGF)-beta1 against MAGE-6 peptides was not observed, suggesting that specific Th3/Tr-type CD4(+) subsets were not common events in these patients [1].
  • In this study, we have assessed whether peripheral blood CD4(+) T cells from human histocompatibility leukocyte antigens (HLA)-DRbeta1*0401(+) patients are Th1- or Th2-biased to MAGE-6 epitopes using interferon (IFN)-gamma and interleukin (IL)-5 enzyme-linked immunospot assays, respectively [1].
  • In contrast, photoaffinity labeling of HLA-A29 was efficiently inhibited by these as well as by the MAGE-3 and MAGE-6 nonapeptides [4].
  • We have combined the use of a HLA-DR4/peptide binding algorithm with the IFN-gamma enzyme-linked immunospot assay to identify four nonoverlapping sequences derived from the MAGE-6 protein that served as CD4+ T-cell epitopes in HLA-DR4+ donors [5].
  • Importantly, peptide-specific CD4+ T cells also recognized HLA-DRbeta1*0401+ tumor cells that constitutively expressed the MAGE-6 protein and autologous HLA-DRbeta1*0401+ dendritic cells transfected with MAGE-6 cDNA-elicited CD4+ T cells that reacted against individual peptide epitopes in vitro [5].

Anatomical context of MAGEA6


Associations of MAGEA6 with chemical compounds

  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity analysis of both MAGE2 and MAGE6 transfectants demonstrates a 4-fold increase in resistance to paclitaxel and 2-fold increase in resistance to doxorubicin but not to other drugs, such as topotecan and cisplatin, through a nonmultidrug resistance-1 mechanism [2].

Other interactions of MAGEA6

  • On the other hand, expression was recognized in tumor samples, ranging from 5% of samples for MAGE-6 to 44% for MAGE-8 [8].

Analytical, diagnostic and therapeutic context of MAGEA6


  1. Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. Tatsumi, T., Kierstead, L.S., Ranieri, E., Gesualdo, L., Schena, F.P., Finke, J.H., Bukowski, R.M., Mueller-Berghaus, J., Kirkwood, J.M., Kwok, W.W., Storkus, W.J. J. Exp. Med. (2002) [Pubmed]
  2. Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines. Duan, Z., Duan, Y., Lamendola, D.E., Yusuf, R.Z., Naeem, R., Penson, R.T., Seiden, M.V. Clin. Cancer Res. (2003) [Pubmed]
  3. Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regression. Huang, J., Khong, H.T., Dudley, M.E., El-Gamil, M., Li, Y.F., Rosenberg, S.A., Robbins, P.F. J. Immunother. (2005) [Pubmed]
  4. HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA-A29, and HLA-B44. Luescher, I.F., Romero, P., Kuznetsov, D., Rimoldi, D., Coulie, P., Cerottini, J.C., Jongeneel, C.V. J. Biol. Chem. (1996) [Pubmed]
  5. MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. Tatsumi, T., Kierstead, L.S., Ranieri, E., Gesualdo, L., Schena, F.P., Finke, J.H., Bukowski, R.M., Brusic, V., Sidney, J., Sette, A., Logan, T.F., Kasamon, Y.L., Slingluff, C.L., Kirkwood, J.M., Storkus, W.J. Clin. Cancer Res. (2003) [Pubmed]
  6. A MAGE-6-encoded peptide is recognized by expanded lymphocytes infiltrating a spontaneously regressing human primary melanoma lesion. Zorn, E., Hercend, T. Eur. J. Immunol. (1999) [Pubmed]
  7. A new tumor-specific antigenic peptide encoded by MAGE-6 is presented to cytolytic T lymphocytes by HLA-Cw16. Vantomme, V., Boël, P., De Plaen, E., Boon, T., van der Bruggen, P. Cancer Immun. (2003) [Pubmed]
  8. Expression spectrum of melanoma antigen-encoding gene family members in colorectal carcinoma. Hasegawa, H., Mori, M., Haraguchi, M., Ueo, H., Sugimachi, K., Akiyoshi, T. Arch. Pathol. Lab. Med. (1998) [Pubmed]
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