The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Ada  -  Adenosine deaminase

Drosophila melanogaster

Synonyms: ADA, Adenosine deaminase-like protein, CG11994, Dmel\CG11994, DrosADA, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Ada

  • Adar (adenosine deaminase acting on RNA) mutant flies expressing only genome-encoded, unedited isoforms of ion-channel subunits are viable but show severe locomotion defects [1].
  • A culture medium prepared without adenosine, or depleted of adenosine by using bovine ADA, also stimulates proliferation of imaginal disk cells, and addition of adenosine to this medium inhibits proliferation [2].
  • Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine [2].
  • The ADGF proteins share a novel amino acid motif, "MPKG," within which the proline and lysine residues are also conserved in the ADAL and ADA subfamilies [3].
  • Adenosine deaminase (ADA) catalyzes the hydrolysis of adenosine to inosine [4].
 

Biological context of Ada

 

Anatomical context of Ada

 

Associations of Ada with chemical compounds

References

  1. Tuning of RNA editing by ADAR is required in Drosophila. Keegan, L.P., Brindle, J., Gallo, A., Leroy, A., Reenan, R.A., O'Connell, M.A. EMBO J. (2005) [Pubmed]
  2. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec, M., Dolezal, T., Gazi, M., Pavlova, E., Bryant, P.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Phylogenetic analysis reveals a novel protein family closely related to adenosine deaminase. Maier, S.A., Galellis, J.R., McDermid, H.E. J. Mol. Evol. (2005) [Pubmed]
  4. The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins. Charlab, R., Valenzuela, J.G., Andersen, J., Ribeiro, J.M. Gene (2001) [Pubmed]
  5. dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. Palladino, M.J., Keegan, L.P., O'Connell, M.A., Reenan, R.A. RNA (2000) [Pubmed]
  6. RNA editing and alternative splicing generate mRNA transcript diversity from the Drosophila 4f-rnp locus. Petschek, J.P., Scheckelhoff, M.R., Mermer, M.J., Vaughn, J.C. Gene (1997) [Pubmed]
  7. The emerging role of adenosine deaminases in insects. Dolezelova, E., Zurovec, M., Dolezal, T., Simek, P., Bryant, P.J. Insect Biochem. Mol. Biol. (2005) [Pubmed]
  8. A role for adenosine deaminase in Drosophila larval development. Dolezal, T., Dolezelova, E., Zurovec, M., Bryant, P.J. PLoS Biol. (2005) [Pubmed]
  9. Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system. Akalal, D.B., Bottenstein, J.E., Lee, S.H., Han, J.H., Chang, D.J., Kaang, B.K., Nagle, G.T. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  10. The PurR mutation of Drosophila melanogaster confers resistance to purine and 2,6-diaminopurine by elevating adenosine deaminase activity. Dutton, F.L., Chovnick, A. Mol. Gen. Genet. (1990) [Pubmed]
 
WikiGenes - Universities