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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ACAT1  -  acetyl-CoA acetyltransferase 1

Gallus gallus

 
 
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High impact information on ACAT1

  • The treatment caused a marked increase in the hepatic HMG-CoA reductase and ACAT activities while in the brain a clear decrease was found in these enzyme activities [1].
  • Under these conditions, the plot of ACAT vs. cholesterol mole fraction in the liposomes is sigmoidal [2].
  • ACAT from the yolk sac membrane of chicken eggs 16 d after fertilization has higher activity and better stability than its mammalian liver counterpart [2].
  • Supplementation with exogenous cholesterol stimulated ACAT activity in microsomes obtained from the tissue at the earlier, but not at the later, stages of development suggesting that the enzyme became saturated with microsomal cholesterol as development proceeded [3].
  • PD132301-2, an inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase (ACAT; EC 2.3.1.26), and 1-stearylboronic acid (SBA), a fatty acid analogue, were orally administered to White Leghorn hens in separate experiments to evaluate their effects on layer performance and plasma and egg yolk lipids [4].
 

Biological context of ACAT1

  • Acyl-CoA cholesterol acyltransferase (ACAT) (EC 2.3.1.26) in the yolk sac membrane of chicken eggs plays an important role in the transport of lipids, which serve as both structural components and as an energy source during embryogenesis [2].
 

Anatomical context of ACAT1

 

Associations of ACAT1 with chemical compounds

  • 1. An enzymatic assay for microsomal acyl-CoA: cholesterol acyltransferase (ACAT) activity in chicken hepatic tissues was developed using silicic acid chromatography [6].
 

Analytical, diagnostic and therapeutic context of ACAT1

References

  1. Ethanol and lipid metabolism. Differential effects on liver and brain microsomes. Sanchez-Amate, M.C., Zurera, J.M., Carrasco, M.P., Segovia, J.L., Marco, C. FEBS Lett. (1991) [Pubmed]
  2. Activation of acyl-CoA cholesterol acyltransferase: redistribution in microsomal fragments of cholesterol and its facilitated movement by methyl-beta-cyclodextrin. Cheng, D., Tipton, C.L. Lipids (1999) [Pubmed]
  3. The esterification of cholesterol in the yolk sac membrane of the chick embryo. Shand, J.H., West, D.W., McCartney, R.J., Noble, R.C., Speake, B.K. Lipids (1993) [Pubmed]
  4. Evaluation of two novel biochemicals on plasma and egg yolk lipid composition and laying hen performance. Elkin, R.G., Freed, M., Watkins, B.A., Srebnik, M., Kieft, K.A., Newton, R.S. Poult. Sci. (1993) [Pubmed]
  5. Homeostatic restoration of microsomal lipids and enzyme changes in HMG-CoA reductase and acyl-CoA: cholesterol acyltransferase in chick liver. Garcia-Gonzalez, M., Segovia, J.L., Alejandre, M.J. Mol. Cell. Biochem. (1992) [Pubmed]
  6. Cytosolic modulators of acyl-CoA: cholesterol acyltransferase (ACAT) activity in hepatic tissue of the chicken (Gallus domesticus). Greer, J.L., Hargis, P.S. Comp. Biochem. Physiol., B (1992) [Pubmed]
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