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Gene Review

Acat1  -  acetyl-CoA acetyltransferase 1

Rattus norvegicus

Synonyms: Acetoacetyl-CoA thiolase, Acetyl-CoA acetyltransferase, mitochondrial
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  1. Molecular cloning and nucleotide sequence of cDNA encoding the entire precursor of rat mitochondrial acetoacetyl-CoA thiolase. Fukao, T., Kamijo, K., Osumi, T., Fujiki, Y., Yamaguchi, S., Orii, T., Hashimoto, T. J. Biochem. (1989) [Pubmed]
  2. Pseudoketogenesis in the perfused rat heart. Fink, G., Desrochers, S., Des Rosiers, C., Garneau, M., David, F., Daloze, T., Landau, B.R., Brunengraber, H. J. Biol. Chem. (1988) [Pubmed]
  3. Mitochondrial metabolism of 3-mercaptopropionic acid. Chemical synthesis of 3-mercaptopropionyl coenzyme A and some of its S-acyl derivatives. Cuebas, D., Beckmann, J.D., Frerman, F.E., Schulz, H. J. Biol. Chem. (1985) [Pubmed]
  4. 4-Bromocrotonic acid, an effective inhibitor of fatty acid oxidation and ketone body degradation in rat heart mitochondria. On the rate-determining step of beta-oxidation and ketone body degradation in heart. Olowe, Y., Schulz, H. J. Biol. Chem. (1982) [Pubmed]
  5. Effect of phenylmethylsulfonyl fluoride on sterol biosynthesis in 10,000 x g supernatant fraction of rat liver homogenates. Raulston, D.L., Schroepfer, G.J. J. Biol. Chem. (1981) [Pubmed]
  6. Regulation of ketogenesis. Mitochondrial acetyl-CoA acetyltransferase from rat liver: initial-rate kinetics in the presence of the product CoASH reveal intermediary plateau regions. Huth, W., Menke, R. Eur. J. Biochem. (1982) [Pubmed]
  7. Cholesterol synthesis and related enzymes in rat liver during pregnancy. Leoni, S., Spagnuolo, S., Conti Devirgiliis, L., Mangiantini, M.T., Trentalance, A. Experientia (1984) [Pubmed]
  8. Synthesis of chloromethyl ketone derivatives of fatty acids. Their use as specific inhibitors of acetoacetyl-coenzyme A thiolase, cholesterol biosynthesis and fatty acid synthesis. Bloxham, D.P., Chalkley, R.A., Coghlin, S.J., Salam, W. Biochem. J. (1978) [Pubmed]
  9. Identification of the CoA-modified forms of mitochondrial acetyl-CoA acetyltransferase and of glutamate dehydrogenase as nearest-neighbour proteins. Schwerdt, G., Möller, U., Huth, W. Biochem. J. (1991) [Pubmed]
  10. Hormonal regulation of the mRNA encoding the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in neonatal primary cultures of cortical astrocytes and meningeal fibroblasts. Cullingford, T.E., Bhakoo, K.K., Clark, J.B. J. Neurochem. (1998) [Pubmed]
  11. Changes in the activities of the enzymes of hepatic fatty acid oxidation during development of the rat. Foster, P.C., Bailey, E. Biochem. J. (1976) [Pubmed]
  12. Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes. Antonenkov, V.D., Croes, K., Waelkens, E., Van Veldhoven, P.P., Mannaerts, G.P. Eur. J. Biochem. (2000) [Pubmed]
  13. Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A generating systems for cholesterogenesis and ketogenesis. Clinkenbeard, K.D., Reed, W.D., Mooney, R.A., Lane, M.D. J. Biol. Chem. (1975) [Pubmed]
  14. Cycloheximide inhibits sterol biosynthesis in cell-free preparations of rat liver. Raulston, D.L., Miller, L.R., Schroepfer, G.J. J. Biol. Chem. (1980) [Pubmed]
  15. Selective inhibition of cholesterol synthesis by cell-free preparations of rat liver by using inhibitors of cytoplasmic acetoacetyl-coenzyme A thiolase. Bloxham, D.P. Biochem. J. (1975) [Pubmed]
  16. Turnover and transformation of mitochondrial acetyl-CoA acetyltransferase into CoA-modified forms. Schwerdt, G., Huth, W. Biochem. J. (1993) [Pubmed]
  17. Effect of phenylalanine metabolites on the activities of enzymes of ketone-body utilization in brain of suckling rats. Benavides, J., Gimenez, C., Valdivieso, F., Mayor, F. Biochem. J. (1976) [Pubmed]
  18. Stimulation of hepatic cholesterol biosynthesis by fatty acids. Effects of oleate on cytoplasmic acetoacetyl-CoA thiolase, acetoacetyl-CoA synthetase and hydroxymethylglutaryl-CoA synthase. Salam, W.H., Wilcox, H.G., Cagen, L.M., Heimberg, M. Biochem. J. (1989) [Pubmed]
  19. An explanation for ketogenesis by the intestine of the suckling rat: the presence of an active hydroxymethylglutaryl-coenzyme A pathway. Békési, A., Williamson, D.H. Biol. Neonate (1990) [Pubmed]
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