Gene Review:
ACAT1 - acetyl-CoA acetyltransferase 1
Homo sapiens
Synonyms:
ACAT, Acetoacetyl-CoA thiolase, Acetyl-CoA acetyltransferase, mitochondrial, MAT, T2, ...
- A patient with severe neurologic symptoms and acetoacetyl-CoA thiolase deficiency. Groot, C.J., Haan, G.L., Hulstaert, C.E., Hoomes, F.A. Pediatr. Res. (1977)
- Identification of a novel exonic mutation at -13 from 5' splice site causing exon skipping in a girl with mitochondrial acetoacetyl-coenzyme A thiolase deficiency. Fukao, T., Yamaguchi, S., Wakazono, A., Orii, T., Hoganson, G., Hashimoto, T. J. Clin. Invest. (1994)
- Identification of three mutant alleles of the gene for mitochondrial acetoacetyl-coenzyme A thiolase. A complete analysis of two generations of a family with 3-ketothiolase deficiency. Fukao, T., Yamaguchi, S., Orii, T., Schutgens, R.B., Osumi, T., Hashimoto, T. J. Clin. Invest. (1992)
- A stable upstream stem-loop structure enhances selection of the first 5'-ORF-AUG as a main start codon for translation initiation of human ACAT1 mRNA. Yang, L., Chen, J., Chang, C.C., Yang, X.Y., Wang, Z.Z., Chang, T.Y., Li, B.L. Acta Biochim. Biophys. Sin. (Shanghai) (2004)
- ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia. Rudel, L.L., Lee, R.G., Parini, P. Arterioscler. Thromb. Vasc. Biol. (2005)
- Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation. Cho, K.H., An, S., Lee, W.S., Paik, Y.K., Kim, Y.K., Jeong, T.S. Biochem. Biophys. Res. Commun. (2003)
- Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon. An, S., Park, Y.D., Paik, Y.K., Jeong, T.S., Lee, W.S. Bioorg. Med. Chem. Lett. (2007)
- Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Rudel, L.L., Lee, R.G., Cockman, T.L. Curr. Opin. Lipidol. (2001)
- Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies. Sakashita, N., Miyazaki, A., Chang, C.C., Chang, T.Y., Kiyota, E., Satoh, M., Komohara, Y., Morganelli, P.M., Horiuchi, S., Takeya, M. Lab. Invest. (2003)
- Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma. Song, B.L., Wang, C.H., Yao, X.M., Yang, L., Zhang, W.J., Wang, Z.Z., Zhao, X.N., Yang, J.B., Qi, W., Yang, X.Y., Inoue, K., Lin, Z.X., Zhang, H.Z., Kodama, T., Chang, C.C., Liu, Y.K., Chang, T.Y., Li, B.L. Biochem. J. (2006)
- Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe. Kitayama, K., Tanimoto, T., Koga, T., Terasaka, N., Fujioka, T., Inaba, T. Eur. J. Pharmacol. (2006)
- Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases. Fukao, T., Song, X.Q., Mitchell, G.A., Yamaguchi, S., Sukegawa, K., Orii, T., Kondo, N. Pediatr. Res. (1997)
- Towards compendia of negative genetic association studies: an example for Alzheimer disease. Blomqvist, M.E., Reynolds, C., Katzov, H., Feuk, L., Andreasen, N., Bogdanovic, N., Blennow, K., Brookes, A.J., Prince, J.A. Hum. Genet. (2006)
- Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzyme's quaternary structure and catalytic efficiency. Yu, C., Zhang, Y., Lu, X., Chen, J., Chang, C.C., Chang, T.Y. Biochemistry (2002)
- Activities of 3-hydroxybutyrate dehydrogenase, 3-oxoacid CoA-transferase and acetoacetyl-CoA thiolase in relation to ketone-body utilisation in muscles from vertebrates and invertebrates. Beis, A., Zammit, V.A., Newsholme, E.A. Eur. J. Biochem. (1980)
- Inborn errors of isoleucine degradation: A review. Korman, S.H. Mol. Genet. Metab. (2006)
- Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. Anderson, R.A., Joyce, C., Davis, M., Reagan, J.W., Clark, M., Shelness, G.S., Rudel, L.L. J. Biol. Chem. (1998)
- Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipids. Kushwaha, R.S., Rosillo, A., Rodriguez, R., McGill, H.C. J. Nutr. Biochem. (2005)