Disease relevance of ART3

• ART3 protein was detected neither within a seminoma nor on Leydig cells [1].

High impact information on ART3

• When measuring expression of the mRNA of ART1, 3, 4 and 5, only ART3 mRNA was detected in unstimulated monocytes [2].
• In accord with these findings, we identified ART3 and ART4 mRNAs through reverse transcription- polymerase chain reaction of polyadenine-positive RNA from human trachea [3].
• We have now identified six related expressed sequence tags (ESTs) in the public database and cloned the two novel human genes from which these are derived (designated ART3 and ART4) [4].
• Methods: ART3 mRNA was determined in human testes and sperm by reverse transcription-polymerase chain reaction (RT-PCR) [1].
• The absence of ART3 from spermatozoa was confirmed by FACS-analysis [1].

Biological context of ART3

• Conclusion: Here we show for the first time that ART3 protein is expressed in testes in particular on spermatocytes, indicating that ART3 exerts a specific function only required at a particular stage of spermatogenesis [1].

Anatomical context of ART3

• Results: ART3 protein was shown to be present in testes [1].

References