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Gene Review

ART3  -  ADP-ribosyltransferase 3

Homo sapiens

Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 3, ARTC3, Ecto-ADP-ribosyltransferase 3, Mono(ADP-ribosyl)transferase 3, NAD(P)(+)--arginine ADP-ribosyltransferase 3, ...
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Disease relevance of ART3


High impact information on ART3

  • When measuring expression of the mRNA of ART1, 3, 4 and 5, only ART3 mRNA was detected in unstimulated monocytes [2].
  • In accord with these findings, we identified ART3 and ART4 mRNAs through reverse transcription- polymerase chain reaction of polyadenine-positive RNA from human trachea [3].
  • We have now identified six related expressed sequence tags (ESTs) in the public database and cloned the two novel human genes from which these are derived (designated ART3 and ART4) [4].
  • Methods: ART3 mRNA was determined in human testes and sperm by reverse transcription-polymerase chain reaction (RT-PCR) [1].
  • The absence of ART3 from spermatozoa was confirmed by FACS-analysis [1].

Biological context of ART3


Anatomical context of ART3


  1. Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes. Friedrich, M., Grahnert, A., Paasch, U., Tannapfel, A., Koch-Nolte, F., Hauschildt, S. Asian J. Androl. (2006) [Pubmed]
  2. Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide. Grahnert, A., Friedrich, M., Pfister, M., Haag, F., Koch-Nolte, F., Hauschildt, S. Biochem. J. (2002) [Pubmed]
  3. Selective expression of RT6 superfamily in human bronchial epithelial cells. Balducci, E., Horiba, K., Usuki, J., Park, M., Ferrans, V.J., Moss, J. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  4. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. Koch-Nolte, F., Haag, F., Braren, R., Kühl, M., Hoovers, J., Balasubramanian, S., Bazan, F., Thiele, H.G. Genomics (1997) [Pubmed]
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