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Gene Review

decay  -  death executioner caspase related to...

Drosophila melanogaster

Synonyms: CAS3, CC3, CG14902, Cas3, Casp 3, ...
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Disease relevance of decay

  • In mammalian cells we tested sequence-specific small dsRNAs of 22 nt; these rescued the toxicity and caspase-3 activation induced by plasmids expressing a transcript encoding an expanded polyglutamine tract [1].
  • These results demonstrate that PTD-BIR3-RING could attenuate cell death in OGD hippocampal slices and decrease cell apoptosis in tMCAO brains through inhibiting of caspase-3 cleavage, suggesting that PTD-mediated protein transduction provides a novel and effective approach for the therapies of brain diseases such as cerebral ischemia [2].

High impact information on decay

  • Here, we show that after UV radiation, MIHA prevented apoptosis by inhibiting caspase 9 and caspase 3 activation [3].
  • The reduced viability of these cells correlated with the induction of markers of apoptosis including membrane blebbing and stimulation of caspase-3-like activity [4].
  • An antibody raised against a peptide from human caspase 3 was used to investigate how extracellular signals controlled spatial patterning of cell death [5].
  • Recombinant DECAY exhibited substrate specificity similar to the mammalian caspase-3 subfamily [6].
  • hTID1, a human homologue of Drosophila tumor suppressor, I(2)tid regulates the release of cytochrome c from mitochondria and subsequent alteration of caspase-3 activity on apoptosis induced by exogenous stimuli, such as tumor necrosis factor-alpha and mitomycin C [7].

Biological context of decay

  • Moreover, incubation of the developing egg chambers with the caspase-3 inhibitor Z-DEVD-FMK significantly delays development, prevents DNA fragmentation, but does not affect chromatin condensation [8].
  • We have demonstrated a novel anti-apoptotic effect of insulin (approximately 50%) in these cells, measured by caspase 3-like activity, which contributed to the increase in cell number [9].

Anatomical context of decay

  • Further biochemical data suggest that SfIAP and CpIAP are specific inhibitors of mammalian caspase-9, the pinnacle caspase in the mitochondria/cytochrome c pathway for apoptosis, but are not inhibitors of downstream caspase-3 and caspase-7 [10].
  • KA triggered neuronal death in the ipsilateral CA3 subfield of the hippocampus and activation of caspase-3 and -9 [11].

Associations of decay with chemical compounds

  • Both Ac-YVAD aldehyde and Ac-DEVD aldehyde, specific inhibitors of caspase 1- and caspase 3-like proteases, respectively, inhibited the FasC-induced death of Drosophila cells [12].
  • The ability of insulin to increase cell number, stimulate bromodeoxyuridine incorporation and reduce caspase 3-like activity was prevented by PD98059, which inhibits activation of the Drosophila extracellular signal regulated kinase (DERK) pathway, and was unaffected by wortmannin, an inhibitor of Drosophila phosphatidylinositol 3-kinase (DPI3K) [9].

Other interactions of decay


Analytical, diagnostic and therapeutic context of decay

  • Intraperitoneal injection of PTD-BIR3-RING could attenuate terminal deoynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) positive cells and decrease cleaved caspase-3 in the ischemic bounder zone compared with the control animals (p < 0.05) [2].


  1. Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference. Caplen, N.J., Taylor, J.P., Statham, V.S., Tanaka, F., Fire, A., Morgan, R.A. Hum. Mol. Genet. (2002) [Pubmed]
  2. Apoptosis inhibition in ischemic brain by intraperitoneal PTD-BIR3-RING (XIAP). Fan, Y.F., Lu, C.Z., Xie, J., Zhao, Y.X., Yang, G.Y. Neurochem. Int. (2006) [Pubmed]
  3. DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9. Ekert, P.G., Silke, J., Hawkins, C.J., Verhagen, A.M., Vaux, D.L. J. Cell Biol. (2001) [Pubmed]
  4. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Silverstein, A.M., Barrow, C.A., Davis, A.J., Mumby, M.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Yu, S.Y., Yoo, S.J., Yang, L., Zapata, C., Srinivasan, A., Hay, B.A., Baker, N.E. Development (2002) [Pubmed]
  6. DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7. Dorstyn, L., Read, S.H., Quinn, L.M., Richardson, H., Kumar, S. J. Biol. Chem. (1999) [Pubmed]
  7. Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. Sasaki, S., Nakamura, T., Arakawa, H., Mori, M., Watanabe, T., Nagawa, H., Croce, C.M. Oncogene (2002) [Pubmed]
  8. Chromatin condensation of ovarian nurse and follicle cells is regulated independently from DNA fragmentation during Drosophila late oogenesis. Nezis, I.P., Stravopodis, D.J., Margaritis, L.H., Papassideri, I.S. Differentiation (2006) [Pubmed]
  9. Insulin reduces apoptosis and increases DNA synthesis and cell size via distinct signalling pathways in Drosophila Kc cells. Bikopoulos, G., Ceddia, R.B., Sweeney, G., Hilliker, A.J. Cell Prolif. (2004) [Pubmed]
  10. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Huang, Q., Deveraux, Q.L., Maeda, S., Salvesen, G.S., Stennicke, H.R., Hammock, B.D., Reed, J.C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. Li, T., Fan, Y., Luo, Y., Xiao, B., Lu, C. Exp. Neurol. (2006) [Pubmed]
  12. Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells. Kondo, T., Yokokura, T., Nagata, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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