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Gene Review:

HOXB5 - homeobox B5

Gallus gallus

Synonyms: Ghox-2.1, Hoxb-5

Wedden, S.E. et al., Sakiyama, J. et al., Bel-Vialar, S. et al., Sakiyama, J. et al.

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High impact information on HOXB5

Conversely, the 3' HoxB genes (Hoxb1 and Hoxb3-Hoxb5) are sensitive to RA but not FGF treatments at these stages [1].
Dorsal root ganglia and the lung rudiment also contain Ghox 2.1 message, but in somewhat lower amounts [2].
Mid- and forebrain, the heart, presomitic mesenchyme and notochord do not contain detectable levels of Ghox 2.1 mRNA [2].
In situ hybridization with 35S-labelled antisense riboprobes derived from Ghox 2.1 demonstrates that this gene is expressed at high levels in spinal chord, myelencephalon and mesonephros [2].
Of particular interest is the expression of Ghox 2.1 in a well-defined patch of mesenchymal tissue situated in an anterioproximal region of the limb bud [2].

Anatomical context of HOXB5

Hoxb-5 and Hoxb-6 expression domains demarcate the trachea, bronchial tree, and air sacs [3].
We analyzed the spatial expression patterns of Hox genes belonging to the HoxA and HoxB cluster (Hoxa-4 approximately a-9, Hoxb-5 approximately b-9) in the developing chick digestive tract [4].

References

Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Bel-Vialar, S., Itasaki, N., Krumlauf, R. Development (2002) [Pubmed]
Expression pattern of homeobox-containing genes during chick embryogenesis. Wedden, S.E., Pang, K., Eichele, G. Development (1989) [Pubmed]
Coordinated expression of Hoxb genes and signaling molecules during development of the chick respiratory tract. Sakiyama, J., Yokouchi, Y., Kuroiwa, A. Dev. Biol. (2000) [Pubmed]
HoxA and HoxB cluster genes subdivide the digestive tract into morphological domains during chick development. Sakiyama, J., Yokouchi, Y., Kuroiwa, A. Mech. Dev. (2001) [Pubmed]

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HOXB5	Canis lupus familiaris
HOXB5	Homo sapiens
HOXB5	Macaca mulatta
Hoxb5	Mus musculus
HOXB5	Pan troglodytes
Hoxb5	Rattus norvegicus
hoxb5	Xenopus (Silurana) tropicalis

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