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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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High impact information on Mesonephros


Biological context of Mesonephros


Anatomical context of Mesonephros

  • AT2 mRNA was present in peripheral interstitial/tissue of the mesonephros, and interstitial tissue surrounding developing glomeruli, but not the outermost nephrogenic mesenchyme in the metanephros from 40 to approximately 131 days (the period of active nephrogenesis) [10].
  • Organ cultures of isolated testes or testis-mesonephros grafts confirmed that p75NTR+ cells do not appear in the testis unless a mesonephros is attached to it [11].
  • Diffuse VEGF expression was detected in hypoxic areas of neural tube, myocardium, digestive tube, and most prominently in mesonephros [12].
  • Later in development, RIHB is detected in the basement membrane under the epidermis, throughout the developing limbs, and in the lamina of various developing organs, such as the eye, the pulmonary bud, the intestine, and the mesonephros [13].
  • The embryonic Sertoli cells are the first testicular cells to differentiate and have been shown to express neurotropin-3 (NT3), which can act on high-affinity trkC receptors expressed on migrating mesonephros cells [14].

Associations of Mesonephros with chemical compounds

  • Ontogeny of angiotensin II receptors, types 1 and 2, in ovine mesonephros and metanephros [10].
  • In mesonephroi cultured in the absence of sugars or in the presence of maltose, the expression pattern of these two marker molecules resembles that found in the mesonephros in vivo [15].
  • The large number of estrogen-concentrating cells in the mesonephros and interrenal and the lack of binding to gonadal tissues indicates that estrogen action on gonadal differentiation during the period of sex determination may be indirect [16].
  • In freeze-fracture replicas of the entire cross-fractured mesonephros of 18 day rabbit embryos the basolateral and luminal cell faces of the different nephron segments were studied and compared with their metanephric counterparts [17].
  • These data suggest that the mesonephros, as well as the gonad, in both sexes is capable of synthesizing steroid [18].

Gene context of Mesonephros

  • We have demonstrated that during culture under 5% O(2,) the addition of recombinant human VEGF or FGF2 to mouse embryonic aorta explants (thoracic level to lateral vessels supplying the mesonephros and metanephros) stimulates microvessel formation [19].
  • MFG-E8 protein was accumulated extracellularly in the interstitial tissues at the boundary of the mesonephros and the genital ridges [20].
  • Whole-mount in situ hybridization indicated that ADH1 expression was first localized in the pronephros during Xenopus embryogenesis, thus conserved with mouse embryonic ADH1 which is first expressed in the mesonephros [21].
  • These results suggest that nestin is required transiently during the development of the testis and mesonephros [22].
  • IGF-II immunostaining was found in all organs examined, with strongest immunoreactivity in spinal ganglia, tubular cells of the mesonephros and peri- and epidermal layers of the skin [23].

Analytical, diagnostic and therapeutic context of Mesonephros


  1. The erythropoietin gene is expressed strongly in the mammalian mesonephric kidney. Wintour, E.M., Butkus, A., Earnest, L., Pompolo, S. Blood (1996) [Pubmed]
  2. Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Grote, D., Souabni, A., Busslinger, M., Bouchard, M. Development (2006) [Pubmed]
  3. Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Patterson, L.T., Pembaur, M., Potter, S.S. Development (2001) [Pubmed]
  4. Polysialic acid and N-CAM localisation in embryonic rat kidney: mesenchymal and epithelial elements show different patterns of expression. Lackie, P.M., Zuber, C., Roth, J. Development (1990) [Pubmed]
  5. A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract. Shao, X., Johnson, J.E., Richardson, J.A., Hiesberger, T., Igarashi, P. J. Am. Soc. Nephrol. (2002) [Pubmed]
  6. Primary structure and expression of a chicken cDNA encoding a protein with zinc-finger motifs. Benn, A., Antoine, M., Beug, H., Niessing, J. Gene (1991) [Pubmed]
  7. Migration of mesonephric cells into the mammalian gonad depends on Sry. Capel, B., Albrecht, K.H., Washburn, L.L., Eicher, E.M. Mech. Dev. (1999) [Pubmed]
  8. Oestrogens and temperature-dependent sex determination in reptiles: all is in the gonads. Pieau, C., Dorizzi, M. J. Endocrinol. (2004) [Pubmed]
  9. Role of mitotic, pro-apoptotic and anti-apoptotic factors in human kidney development. Carev, D., Krni, D., Saraga, M., Sapunar, D., Saraga-Babi, M. Pediatr. Nephrol. (2006) [Pubmed]
  10. Ontogeny of angiotensin II receptors, types 1 and 2, in ovine mesonephros and metanephros. Butkus, A., Albiston, A., Alcorn, D., Giles, M., McCausland, J., Moritz, K., Zhuo, J., Wintour, E.M. Kidney Int. (1997) [Pubmed]
  11. Mesenchymal cell precursors of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor. Campagnolo, L., Russo, M.A., Puglianiello, A., Favale, A., Siracusa, G. Biol. Reprod. (2001) [Pubmed]
  12. Experimental hypoxia and embryonic angiogenesis. Nanka, O., Valásek, P., Dvoráková, M., Grim, M. Dev. Dyn. (2006) [Pubmed]
  13. Retinoic acid induced heparin-binding protein expression and localization during gastrulation, neurulation, and organogenesis. Cockshutt, A.M., Jonet, L., Jeanny, J.C., Vigny, M., Raulais, D. Dev. Dyn. (1994) [Pubmed]
  14. Chemotactic role of neurotropin 3 in the embryonic testis that facilitates male sex determination. Cupp, A.S., Uzumcu, M., Skinner, M.K. Biol. Reprod. (2003) [Pubmed]
  15. Endogenous galectins and effect of galectin hapten inhibitors on the differentiation of the chick mesonephros. Murphy, K.M., Zalik, S.E. Dev. Dyn. (1999) [Pubmed]
  16. Sites of estrogen uptake in embryonic Trachemys scripta, a turtle with temperature-dependent sex determination. Gahr, M., Wibbels, T., Crews, D. Biol. Reprod. (1992) [Pubmed]
  17. The mature mesonephric nephron of the rabbit embryo. III. Freeze-fracture studies. Schiller, A., Tiedemann, K. Cell Tissue Res. (1981) [Pubmed]
  18. Steroid contents of and steroidogenesis in vitro by the developing gonad and mesonephros around sexual differentiation in fetal sheep. Lun, S., Smith, P., Lundy, T., O'Connell, A., Hudson, N., McNatty, K.P. J. Reprod. Fertil. (1998) [Pubmed]
  19. Microvessel formation from mouse aorta is stimulated in vitro by secreted VEGF and extracts from metanephroi. Akimoto, T., Hammerman, M.R. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  20. Identification of a stromal cell type characterized by the secretion of a soluble integrin-binding protein, MFG-E8, in mouse early gonadogenesis. Kanai, Y., Kanai-Azuma, M., Tajima, Y., Birk, O.S., Hayashi, Y., Sanai, Y. Mech. Dev. (2000) [Pubmed]
  21. Alcohol dehydrogenases in Xenopus development: conserved expression of ADH1 and ADH4 in epithelial retinoid target tissues. Hoffmann, I., Ang, H.L., Duester, G. Dev. Dyn. (1998) [Pubmed]
  22. The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse. Fröjdman, K., Pelliniemi, L.J., Lendahl, U., Virtanen, I., Eriksson, J.E. Differentiation (1997) [Pubmed]
  23. Immunohistochemical localization of insulin-like growth factor binding protein-1, -3 and -4 in human fetal tissues and their analysis in media from fetal tissue explants. Braulke, T., Götz, W., Claussen, M. Growth Regul. (1996) [Pubmed]
  24. Quantitative analysis of embryonic kidney impairment by confocal microscopy and stereology: effect of 1,2-dibromoethane in the chick mesonephros. Náprstková, I., Radochová, B., Novotná, B., Jirkovská, M., Janácek, J., Kubínová, L. Br. Poult. Sci. (2005) [Pubmed]
  25. Influence of mesonephros on foetal and neonatal rabbit gonads. II. Sex-steroid release by the ovary in vitro. Grinsted, J. Acta Endocrinol. (1982) [Pubmed]
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