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Gene Review

BMP7  -  bone morphogenetic protein 7

Gallus gallus

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High impact information on BMP7


Biological context of BMP7


Anatomical context of BMP7

  • PURPOSE: The purpose of this study was to investigate the regulation of photoreceptor differentiation and outer segment elongation by the growth factor BMP7 [10].
  • BMP7 did not appear to affect the survival, proliferation, or differentiation of progenitors or the fate of photoreceptors or amacrine cells in vitro [10].
  • In addition, precocious expression of Bmp7 in the metatarsal epidermis of the Silkie mutant or treatment of the metatarsus with ectopic BMP7 protein results in feather development from scale forming integument [11].
  • Two members of the BMP superfamily, BMP4 and BMP7, which may regulate neural crest development, are highly expressed by cells at the site of iris smooth muscle generation [12].
  • Constructs were transiently transfected into sternal chondrocytes cultured under SF conditions in the presence or absence of 30 ng/ml BMP-2, BMP-4, or BMP-7 [13].

Associations of BMP7 with chemical compounds

  • This report demonstrates that the function of BMP-7 in the oviduct involves the induction of apoptosis and that estrogen plays an important role in opposing this function [1].

Other interactions of BMP7

  • During the early developmental stages, BMP-2 and BMP-7 are expressed in the posterior distal mesenchyme leaving a less prominent expression anteriorly [14].
  • Our results indicate that the ADMP pathway causes the restriction of anterior and axial fates and that ADMP, BMP2b, and BMP7 pathways have distinct actions but cooperate in establishing proper dorso-ventral regionalization [15].
  • Finally, BMP-7 stimulated G cell proliferation, but BMP-4 inhibited TGF-alpha+ IGF-I- and/or FSH-stimulated G cell proliferation, suggesting a role in the control of follicular growth during development [16].

Analytical, diagnostic and therapeutic context of BMP7


  1. Estrogen opposes the apoptotic effects of bone morphogenetic protein 7 on tissue remodeling. Monroe, D.G., Jin, D.F., Sanders, M.M. Mol. Cell. Biol. (2000) [Pubmed]
  2. Foregut endoderm is required at head process stages for anteriormost neural patterning in chick. Withington, S., Beddington, R., Cooke, J. Development (2001) [Pubmed]
  3. Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling. Vesque, C., Ellis, S., Lee, A., Szabo, M., Thomas, P., Beddington, R., Placzek, M. Development (2000) [Pubmed]
  4. Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Streit, A., Lee, K.J., Woo, I., Roberts, C., Jessell, T.M., Stern, C.D. Development (1998) [Pubmed]
  5. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Macias, D., Gañan, Y., Sampath, T.K., Piedra, M.E., Ros, M.A., Hurle, J.M. Development (1997) [Pubmed]
  6. The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate. von Frowein, J., Wizenmann, A., Götz, M. Dev. Biol. (2006) [Pubmed]
  7. Assignment of fourteen microsatellite markers to the chicken linkage map. Jacobsson, L., Park, H.B., Wahlberg, P., Jiang, S., Siegel, P.B., Andersson, L. Poult. Sci. (2004) [Pubmed]
  8. Molecular cloning and expression of bone morphogenetic protein-7 in the chick epiphyseal growth plate. Houston, B., Thorp, B.H., Burt, D.W. J. Mol. Endocrinol. (1994) [Pubmed]
  9. Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. Groppe, J., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Belmonte, J.C., Choe, S. The Journal of bone and joint surgery. American volume. (2003) [Pubmed]
  10. Bone morphogenetic protein 7 increases chick photoreceptor outer segment initiation. Sehgal, R., Andres, D.J., Adler, R., Belecky-Adams, T.L. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  11. Bmp7 mediates early signaling events during induction of chick epidermal organs. Harris, M.P., Linkhart, B.L., Fallon, J.F. Dev. Dyn. (2004) [Pubmed]
  12. Potential roles for BMP and Pax genes in the development of iris smooth muscle. Jensen, A.M. Dev. Dyn. (2005) [Pubmed]
  13. A BMP responsive transcriptional region in the chicken type X collagen gene. Volk, S.W., Luvalle, P., Leask, T., Leboy, P.S. J. Bone Miner. Res. (1998) [Pubmed]
  14. Expression pattern of BMPs during chick limb development. Geetha-Loganathan, P., Nimmagadda, S., Huang, R., Scaal, M., Christ, B. Anat. Embryol. (2006) [Pubmed]
  15. Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Willot, V., Mathieu, J., Lu, Y., Schmid, B., Sidi, S., Yan, Y.L., Postlethwait, J.H., Mullins, M., Rosa, F., Peyriéras, N. Dev. Biol. (2002) [Pubmed]
  16. BMPs and BMPRs in chicken ovary and effects of BMP-4 and -7 on granulosa cell proliferation and progesterone production in vitro. Onagbesan, O.M., Bruggeman, V., Van As, P., Tona, K., Williams, J., Decuypere, E. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
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