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Gene Review

TkR99D  -  Tachykinin-like receptor at 99D

Drosophila melanogaster

Synonyms: CG7887, DTKR, DmTRPR, Dmel\CG7887, Dtkr, ...
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Disease relevance of Takr99D


High impact information on Takr99D

  • The cDNAs encode a seven transmembrane domain protein (DTKR) of 519 amino acids with 40-48% amino acid identity to mammalian tachykinin receptors within transmembrane regions [1].
  • The gene encoding DTKR was mapped by in situ hybridization to a single location at 99D on the right arm of chromosome 3 [1].
  • We determined that HEK-293 cells transfected with DTKR displayed dose-dependent increases in both intracellular calcium and cyclic AMP levels in response to the different DTK peptides [2].
  • In the fifth, sixth and seventh transmembrane regions the deduced amino acid sequence of LTKR exhibits 79% sequence identity to the DTKR receptor and 54% to that of NKD [3].

Biological context of Takr99D

  • Northern and PCR amplification analysis showed that while DTKR transcripts are present at all stages, high levels of expression occur in later stages of embryogenesis (starting at 10-14 h), coinciding with the beginning of major periods of neural development [1].

Anatomical context of Takr99D


Associations of Takr99D with chemical compounds

  • Gly- and Ala-containing tachykinins are both encoded in the Drosophila tachykinin precursor, thus raising the question of whether DTKR can also distinguish between these two tachykinin types [4].


  1. Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides. Li, X.J., Wolfgang, W., Wu, Y.N., North, R.A., Forte, M. EMBO J. (1991) [Pubmed]
  2. Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides. Birse, R.T., Johnson, E.C., Taghert, P.H., Nässel, D.R. J. Neurobiol. (2006) [Pubmed]
  3. A putative tachykinin receptor in the cockroach brain: molecular cloning and analysis of expression by means of antisera to portions of the receptor protein. Johard, H.A., Muren, J.E., Nichols, R., Larhammar, D.S., Nässel, D.R. Brain Res. (2001) [Pubmed]
  4. Functional comparison of two evolutionary conserved insect neurokinin-like receptors. Poels, J., Verlinden, H., Fichna, J., Van Loy, T., Franssens, V., Studzian, K., Janecka, A., Nachman, R.J., Broeck, J.V. Peptides (2007) [Pubmed]
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