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Gene Review

Tacr3  -  tachykinin receptor 3

Rattus norvegicus

Synonyms: NK-3 receptor, NK-3R, NKR, Neurokinin B receptor, Neuromedin-K receptor, ...
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Disease relevance of Tacr3


Psychiatry related information on Tacr3


High impact information on Tacr3

  • The results indicated that selection in WGA after mutagenic treatment of a metastatic parental tumor cell line (MDAY-D2), which was M phi-sensitive (M phi S) and NK-resistant (NKR), can result in the isolation of a significantly M phi-resistant (M phi R) and NK-sensitive (NKS) tumor variant, MDW4 [8].
  • Results: Cholera toxin-induced water and electrolyte secretion was inhibited by the substance P antagonists and the NK-1 and NK-2 receptor antagonists, but not by the NK-3 receptor antagonist or by pretreatment with capsaicin [9].
  • RESULTS: In awake rats, intraperitoneal administration of the NK3-receptor antagonist SR 142,801 reduced, whereas the NK3-receptor agonist senktide increased, both the rectocolonic inhibitory reflex and abdominal contractions produced by colorectal distention [10].
  • In cells coexpressing both receptors, prior activation of the NK1R inhibited endocytosis and homologous desensitization of the NK3R, which was dose-dependently reversed by overexpression of beta-ARR1 [11].
  • Thus, the high-affinity and prolonged interaction of the NK1R with beta-ARRs depletes beta-ARRs from the cytosol and limits their role in desensitization and endocytosis of the NK3R [11].

Chemical compound and disease context of Tacr3


Biological context of Tacr3


Anatomical context of Tacr3


Associations of Tacr3 with chemical compounds

  • E2 treatment decreased by 15-fold NK3R mRNA [22].
  • This stimulated effect of substance P was antagonized by the NK1--receptor antagonist (5 x 10(-7) M), but not by the NK3-receptor antagonist (5 x 10(-7) M) [23].
  • The stimulant effect of PG-KII on guinea pig acini was significantly reduced by the NK3-receptor antagonist, SR 142801 (5 x 10(-7) M), and left unchanged by the NK1-receptor antagonist, SR 140333 (5 x 10(-7) M) [23].
  • In this paper we investigated and compared the effect of PG-KII (10(-9) to 10(-6) M), a natural NK3-receptor agonist, with that of the known secretagogues substance P (10(-9) to 10(-6)M), caerulein (10(-11) to 10(-8) M) and carbachol (10(-8) to 10(-5) M), on amylase secretion from dispersed pancreatic acini of the guinea pig and rat [23].
  • In the current study, we furthered our investigations of the role of estrogen in the regulation of NK3-R-mediated myometrial contractility [16].

Regulatory relationships of Tacr3


Other interactions of Tacr3

  • The NK1R resensitized greater than twofold more slowly than the NK3R [14].
  • Thus, although these studies do not identify SP as the NK3-R ligand, they do provide evidence for hypotension-induced release of an endogenous tachykinin in SON and evidence suggesting a role for NK3-Rs in transcription regulation [1].
  • The present study demonstrated that a large proportion of neurokinin B receptor-like immunoreactive neurons in the paraventricular hypothalamic and supraoptic nuclei contained vasopressin-like immunoreactivity, and expressed Fos-like immunoreactivity after intravenous administration of hypertonic saline [25].
  • Neurons showing both neuromedin K receptor-like and choline acetyltransferase immunoreactivities were hardly detected in other aforementioned regions of the forebrain, brainstem and spinal cord [27].
  • The upregulation of NF-kappaB and ICAM-1 was attenuated by NK receptor antagonist and antioxidants [28].

Analytical, diagnostic and therapeutic context of Tacr3


  1. Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. Howe, H.E., Somponpun, S.J., Sladek, C.D. J. Neurosci. (2004) [Pubmed]
  2. Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia. Kamp, E.H., Beck, D.R., Gebhart, G.F. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  3. Intranigral tachykinin NK3 receptor agonist elicits oral movements in rats. Liminga, U., Johansson, P.E., Gunne, L. Pharmacol. Biochem. Behav. (1991) [Pubmed]
  4. Intestinal anti-nociceptive behaviour of NK3 receptor antagonism in conscious rats: evidence to support a peripheral mechanism of action. Fioramonti, J., Gaultier, E., Toulouse, M., Sanger, G.J., Bueno, L. Neurogastroenterol. Motil. (2003) [Pubmed]
  5. Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats. Nagashima, A., Takano, Y., Tateishi, K., Matsuoka, Y., Hamaoka, T., Kamiya, H. Brain Res. (1989) [Pubmed]
  6. Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat. Improta, G., Broccardo, M. Peptides (2000) [Pubmed]
  7. A dose-response analysis of intra-raphe tachykinin-induced hyperactivity. Paris, J.M., Lorens, S.A. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  8. Alterations in sensitivity to nonspecific cell-mediated lysis associated with tumor progression: characterization of activated macrophage- and natural killer cell-resistant tumor variants. Nestel, F.P., Casson, P.R., Wiltrout, R.H., Kerbel, R.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  9. Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum. Turvill, J.L., Connor, P., Farthing, M.J. Gastroenterology (2000) [Pubmed]
  10. Role of neurokinin 3 receptors on responses to colorectal distention in the rat: electrophysiological and behavioral studies. Julia, V., Su, X., Buéno, L., Gebhart, G.F. Gastroenterology (1999) [Pubmed]
  11. Heterologous regulation of trafficking and signaling of G protein-coupled receptors: beta-arrestin-dependent interactions between neurokinin receptors. Schmidlin, F., Déry, O., Bunnett, N.W., Grady, E.F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  12. NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats. Zaratin, P., Angelici, O., Clarke, G.D., Schmid, G., Raiteri, M., Carità, F., Bonanno, G. Neuropharmacology (2000) [Pubmed]
  13. Kainic acid induced seizures cause a marked increase in the expression of neurokinin-3 receptor mRNA in the rat cerebellum. Röder, C., Bellmann, R., McCarson, K.E., Krause, J.E., Sperk, G. Neurosci. Lett. (1994) [Pubmed]
  14. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Schmidlin, F., Roosterman, D., Bunnett, N.W. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  15. Cloning and expression of a rat neuromedin K receptor cDNA. Shigemoto, R., Yokota, Y., Tsuchida, K., Nakanishi, S. J. Biol. Chem. (1990) [Pubmed]
  16. Estrogen-dependent regulation of neurokinin 3 receptor-mediated uterine contractility in the rat. Crane, L.H., Williams, M.J., Nimmo, A.J., Hamlin, G.P. Biol. Reprod. (2002) [Pubmed]
  17. Neurokinin A-induced vasoconstriction and muscular contraction in the rat isolated stomach: mediation by distinct and unusual neurokinin2 receptors. Lippe, I., Wachter, C.H., Holzer, P. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  18. Effects of the peripherally acting NK receptor antagonist, SB-235375, on intestinal and somatic nociceptive responses and on intestinal motility in anaesthetized rats. Shafton, A.D., Bogeski, G., Kitchener, P.D., Lewis, V.A., Sanger, G.J., Furness, J.B. Neurogastroenterol. Motil. (2004) [Pubmed]
  19. Characterization of tachykinin receptors mediating plasma extravasation and vasodilatation in normal and acutely inflamed knee joints of the rat. Lam, F.Y., Wong, M.C. Br. J. Pharmacol. (1996) [Pubmed]
  20. Localization of the neuromedin K receptor (NK3) in the central nervous system of the rat. Ding, Y.Q., Shigemoto, R., Takada, M., Ohishi, H., Nakanishi, S., Mizuno, N. J. Comp. Neurol. (1996) [Pubmed]
  21. Tissue distribution and quantitation of the mRNAs for three rat tachykinin receptors. Tsuchida, K., Shigemoto, R., Yokota, Y., Nakanishi, S. Eur. J. Biochem. (1990) [Pubmed]
  22. Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment. Pinto, F.M., Armesto, C.P., Magraner, J., Trujillo, M., Martín, J.D., Candenas, M.L. Endocrinology (1999) [Pubmed]
  23. Stimulatory effect of PG-KII, an NK3 tachykinin receptor agonist, on isolated pancreatic acini: species-related differences. Linari, G., Improta, G., Agostini, S., Andreassi, A., Broccardo, M. Peptides (2004) [Pubmed]
  24. Messenger RNA localization and further characterisation of the putative tachykinin receptor NK4 (NK3B). Donaldson, L.F., Haskell, C.A., Hanley, M.R. Recept. Channels (2001) [Pubmed]
  25. Neurokinin B receptor (NK3)-containing neurons in the paraventricular and supraoptic nuclei of the rat hypothalamus synthesize vasopressin and express Fos following intravenous injection of hypertonic saline. Ding, Y.Q., Lü, B.Z., Guan, Z.L., Wang, D.S., Xu, J.Q., Li, J.H. Neuroscience (1999) [Pubmed]
  26. GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex. Furuta, T., Koyano, K., Tomioka, R., Yanagawa, Y., Kaneko, T. J. Comp. Neurol. (2004) [Pubmed]
  27. Cholinergic neurons expressing neuromedin K receptor (NK3) in the basal forebrain of the rat: a double immunofluorescence study. Chen, L.W., Wei, L.C., Liu, H.L., Ding, Y.Q., Zhang, H., Rao, Z.R., Ju, G., Chan, Y.S. Neuroscience (2001) [Pubmed]
  28. Thoracic vagal efferent nerve stimulation evokes substance P-induced early airway bronchonstriction and late proinflammatory and oxidative injury in the rat respiratory tract. Li, P.C., Li, S.C., Lin, Y.J., Liang, J.T., Chien, C.T., Shaw, C.F. J. Biomed. Sci. (2005) [Pubmed]
  29. Noradrenergic neurons expressing substance P receptor (NK1) in the locus coeruleus complex: a double immunofluorescence study in the rat. Chen, L.W., Wei, L.C., Liu, H.L., Rao, Z.R. Brain Res. (2000) [Pubmed]
  30. Effects of receptor-selective neurokinin agonists and a neurokinin antagonist on the electrical activity of spinal cord neurones in culture. Wienrich, M., Reuss, K., Harting, J. Br. J. Pharmacol. (1989) [Pubmed]
  31. Differential effects of intraventricular injections of tachykinin NK1 and NK3 receptor agonists on normal and sham drinking of NaCl by sodium-deficient rats. Flynn, F.W., Smith, M.E., Bieber, S.L. Behav. Neurosci. (1999) [Pubmed]
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