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Gene Review

Tacr3  -  tachykinin receptor 3

Mus musculus

Synonyms: NK-3 receptor, NK-3R, NKR, Neurokinin B receptor, Neuromedin-K receptor, ...
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Disease relevance of Tacr3


High impact information on Tacr3

  • The NKR alteration was selective for NK cells and did not result in a resistance to lysis in general; NKR and NKS variants were equally susceptible to (i) cytolysis mediated by alloimmune or lectin-dependent effector T cells and (ii) antibody- and complement-mediated lysis [3].
  • These results are compatible with the hypothesis that the NKR variants have an altered acceptor site on the target cell membrane that normally binds the "lytic moiety" delivered by the effector cell [3].
  • Cytolysis of both NKR and NKS lines was mediated by nylon-nonadherent asialo-GM1+ effector cells, and effectors from poly(I) . poly(C)-boosted mice preferentially lysed the NKS lines [3].
  • The aim of this study was to determine whether chimeric NK-receptor-bearing T cells would directly kill tumor cells and lead to induction of host immunity against tumors [4].
  • Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice [5].

Biological context of Tacr3


Anatomical context of Tacr3


Associations of Tacr3 with chemical compounds

  • In addition, the [Ca2+]i increase by 0.33 microM senktide, an NK3 receptor agonist, was inhibited by SR 142801 but not by SR 48968 [15].
  • In addition, NK2 and NK3 receptor-mediated [Ca2+]i increase was partially attenuated in the absence of extracellular Ca2+ or in the presence of nickel, an inorganic Ca2+ influx blocker, but was unaffected by nifedipine and omega-conotoxin, L- and N-type voltage-dependent Ca2+ channel blockers, respectively [15].
  • Neuro-cutaneous interactions may be mediated by the release of neuropeptides such as substance P (SP) which activate immunocompetent cells in the skin by binding to high affinity neurokinin receptors (NKR) [16].
  • Moreover, it seems unlikely that the NK3 receptor is involved primarily in capsaicin-induced mouse ear oedema [17].
  • Significant GABA release was observed when striatal slices were challenged with the NK-3 receptor agonist senktide, the selectivity of which was confirmed using the NK-3 receptor antagonist SR142801 [18].

Regulatory relationships of Tacr3

  • The specific NK1 receptor antagonist, RP67580 (10(-9) mol per mouse, i.v.) was the most effective in reducing the substance P-induced plasma extravasation when compared with other NK receptor antagonists, FK224 and FK888.(ABSTRACT TRUNCATED AT 250 WORDS)[19]

Other interactions of Tacr3

  • Pretreatment with naloxone, an opioid antagonist, resulted in a reversible effect on the behavioural reduction of NK-2 and NK-3 receptor agonists produced by spantide [11].
  • Neurokinin-3 receptor (NK3R) mRNA expression was absent in both pancreas and lung [20].
  • Furthermore, the depolarization by 60 mM K+ did not affect the [Ca2+]i. These findings suggested that the NK2 and NK3 receptor-mediated [Ca2+]i increase was due to the activation of PLC and was dependent on the mobilization of internal Ca2+ and the entry of extracellular Ca2+ through voltage-independent channels [15].
  • In contrast, these neurons exhibiting both NK-3R and GluR4 immunoreactivity were hardly detected although GluR4-positive neurons were still distributed in the substantia nigra [13].
  • The antinociception caused by i.d. injection of the NK3 receptor antagonist SR 142801 against both phases of the formalin test, but not that of NK1 and NK2 receptor antagonists, was significantly reversed by intraperitoneal (i.p.) injection of naloxone (5 mg/kg) [21].

Analytical, diagnostic and therapeutic context of Tacr3


  1. Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. McMahon, C.W., Zajac, A.J., Jamieson, A.M., Corral, L., Hammer, G.E., Ahmed, R., Raulet, D.H. J. Immunol. (2002) [Pubmed]
  2. Slow receptor acquisition by NK cells regenerated in vivo from transplanted fetal liver or adult bone marrow stem cells. Maeda, M., Uchida, N., Eaves, C.J., Takei, F. Exp. Hematol. (2003) [Pubmed]
  3. Selective natural killer resistance in a clone of YAC lymphoma cells. Roder, J.C., Beaumont, T.J., Kerbel, R.S., Haliotis, T., Kozbor, D. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  4. Chimeric NK-receptor-bearing T cells mediate antitumor immunotherapy. Zhang, T., Lemoi, B.A., Sentman, C.L. Blood (2005) [Pubmed]
  5. Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice. Shimizu, E., Koike, J., Wakao, H., Seino, K., Koseki, H., Kakiuchi, T., Nakayama, T., Taniguchi, M. Blood (2004) [Pubmed]
  6. The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor. Chambers, C.A., Kang, J., Wu, Y., Held, W., Raulet, D.H., Allison, J.P. Blood (2002) [Pubmed]
  7. Activating Ly-49 NK receptors: central role in cytokine and chemokine production. Ortaldo, J.R., Bere, E.W., Hodge, D., Young, H.A. J. Immunol. (2001) [Pubmed]
  8. IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. Taki, S., Nakajima, S., Ichikawa, E., Saito, T., Hida, S. J. Immunol. (2005) [Pubmed]
  9. Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice. Adam, S.G., Caraux, A., Fodil-Cornu, N., Loredo-Osti, J.C., Lesjean-Pottier, S., Jaubert, J., Bubic, I., Jonjic, S., Guénet, J.L., Vidal, S.M., Colucci, F. J. Immunol. (2006) [Pubmed]
  10. Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis. Rhoades, K.L., Singh, N., Simon, I., Glidden, B., Cedar, H., Chess, A. Curr. Biol. (2000) [Pubmed]
  11. Naloxone-reversible effect of spantide on the spinally mediated behavioural response induced by neurokinin-2 and -3 receptor agonists. Sakurada, T., Manome, Y., Katsumata, K., Uchiumi, H., Tan-No, K., Sakurada, S., Kisara, K. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  12. Mechanisms underlying the inhibitory effects of tachykinin receptor antagonists on eosinophil recruitment in an allergic pleurisy model in mice. Alessandri, A.L., Pinho, V., Souza, D.G., Castro, M.S., Klein, A., Teixeira, M.M. Br. J. Pharmacol. (2003) [Pubmed]
  13. Differential co-localization of neurokinin-3 receptor and NMDA/AMPA receptor subunits in neurons of the substantia nigra of C57/BL mice. Wang, Y.Q., Hu, H.J., Cao, R., Chen, L.W. Brain Res. (2005) [Pubmed]
  14. A differentiation between peripheral and central neurokinin receptors using phenoxybenzamine. Vaught, J.L., Scott, R.W., Jacoby, H.I. Eur. J. Pharmacol. (1986) [Pubmed]
  15. Further identification of neurokinin receptor types and mechanisms of calcium signaling evoked by neurokinins in the murine neuroblastoma C1300 cell line. Fukuhara, S., Mukai, H., Kako, K., Nakayama, K., Munekata, E. J. Neurochem. (1996) [Pubmed]
  16. Substance P induction of murine keratinocyte PAM 212 interleukin 1 production is mediated by the neurokinin 2 receptor (NK-2R). Song, I.S., Bunnett, N.W., Olerud, J.E., Harten, B., Steinhoff, M., Brown, J.R., Sung, K.J., Armstrong, C.A., Ansel, J.C. Exp. Dermatol. (2000) [Pubmed]
  17. Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema. Inoue, H., Nagata, N., Koshihara, Y. Inflamm. Res. (1996) [Pubmed]
  18. NK-3 receptors are expressed on mouse striatal gamma-aminobutyric acid-ergic interneurones and evoke [(3)H] gamma-aminobutyric acid release. Preston, Z., Richardson, P.J., Pinnock, R.D., Lee, K. Neurosci. Lett. (2000) [Pubmed]
  19. Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade. Kraneveld, A.D., Buckley, T.L., van Heuven-Nolsen, D., van Schaik, Y., Koster, A.S., Nijkamp, F.P. Br. J. Pharmacol. (1995) [Pubmed]
  20. The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Lau, H.Y., Bhatia, M. J. Pathol. (2006) [Pubmed]
  21. Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Santos, A.R., Calixto, J.B. Neuropeptides (1997) [Pubmed]
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