The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

SP-D  -  surfactant protein D

Ovis aries

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SP-D

  • In conclusion, cell-associated SP-D protein expression significantly decreases within hyperplastic epithelium of lungs from infected animals during chronic bronchopneumonia [1].
  • The purpose of this study was to determine the extent to which parainfluenza type 3 virus infection in neonatal lambs alters expression of sheep beta-defensin 1 (SBD-1), SP-A, and SP-D, all of which are constitutively transcribed by respiratory epithelia [2].
  • At 15 and 45 days post-inoculation, areas of lung had peribronchiolar inflammatory cell infiltrate, epithelial cell hyperplasia, tortuosity of the airway lumens, and decreased intensity of SP-D protein staining and number of positive cells [1].
  • Since a hallmark of bronchopneumonia is the initiation of inflammation in the bronchi and bronchoalveolar junction, we chose a classic ruminant model of bronchopneumonia caused by Mannheimia haemolytica to study the expression of SP-D within the bronchioles of infected lambs [1].
  • Exhaustion of SP-D protein reserves and absence of SP-D gene upregulation during the progression of bacterial pneumonia into chronicity may result in failure to clear the pathogen from the lung and/or cause animals to be more susceptible to re-infection [1].
 

High impact information on SP-D

 

Analytical, diagnostic and therapeutic context of SP-D

References

  1. Surfactant protein D expression in normal and pneumonic ovine lung. Grubor, B., Gallup, J.M., Ramírez-Romero, R., Bailey, T.B., Crouch, E.C., Brogden, K.A., Ackermann, M.R. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  2. Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Grubor, B., Gallup, J.M., Meyerholz, D.K., Crouch, E.C., Evans, R.B., Brogden, K.A., Lehmkuhl, H.D., Ackermann, M.R. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
  3. A recombinant homotrimer, composed of the alpha helical neck region of human surfactant protein D and C1q B chain globular domain, is an inhibitor of the classical complement pathway. Kishore, U., Strong, P., Perdikoulis, M.V., Reid, K.B. J. Immunol. (2001) [Pubmed]
  4. Regulation of surfactant protein and defensin mRNA expression in cultured ovine type II pneumocytes by all-trans retinoic acid and VEGF. Grubor, B., Meyerholz, D.K., Lazic, T., Demacedo, M.M., Derscheid, R.J., Hostetter, J.M., Gallup, J.M., Demartini, J.C., Ackermann, M.R. International journal of experimental pathology. (2006) [Pubmed]
 
WikiGenes - Universities