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Gene Review:

Gab1 - GRB2-associated binding protein 1

Rattus norvegicus

This record was replaced with 361388.

Dixit, M. et al., Korhonen, J.M. et al., Trümper, K. et al., Nakaoka, Y. et al., Holgado-Madruga, M. et al.

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Disease relevance of Gab1

We generated a recombinant adenovirus encoding hemagglutinin (HA)-epitope-tagged Gab1 and expressed this protein in PC12 cells [1].
In this study, we report the role of Gab1 in gp130-mediated cardiac hypertrophy [2].

High impact information on Gab1

The expression of a Gab1 mutant that lacked the binding sites for PI 3-kinase enhanced apoptosis and diminished the protective effect of NGF [3].
These results indicate that Gab1 is capable of mediating differentiation, DNA synthesis, and cell survival and uses both PI3K and MEK signaling pathways to achieve its effects [1].
Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells [1].
In contrast, GLP-1 induced PI 3-K activity mainly in Gab-1 and also in IRS-2 immunoprecipitates, although in an attenuated kinetic [4].
We also demonstrate that the scaffold adapter protein Gab1, considered a physiological activator of protein tyrosine phosphatase SHP2, increases cell motility in the presence but not the absence of insulin [5].

Biological context of Gab1

PC-12 cells that overexpressed Gab1 show a decreased requirement for the amount of NGF necessary to inhibit apoptosis [3].
We constructed three kinds of adenovirus vectors, those carrying wild-type Gab1 (AdGab1WT), mutated Gab1 lacking SHP2 binding site (AdGab1F627/659), and beta-galactosidase (Adbeta-gal) [2].

Anatomical context of Gab1

Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 association [5].
In cells cultured in the presence of insulin, overexpression of Gab1 mimics, whereas a dominant-negative allele of Gab1 (Gab1YF) blocks, the motility-stimulatory effect of NO [5].

References

Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells. Korhonen, J.M., Saïd, F.A., Wong, A.J., Kaplan, D.R. J. Biol. Chem. (1999) [Pubmed]
Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes. Nakaoka, Y., Nishida, K., Fujio, Y., Izumi, M., Terai, K., Oshima, Y., Sugiyama, S., Matsuda, S., Koyasu, S., Yamauchi-Takihara, K., Hirano, T., Kawase, I., Hirota, H. Circ. Res. (2003) [Pubmed]
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Holgado-Madruga, M., Moscatello, D.K., Emlet, D.R., Dieterich, R., Wong, A.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Integrative mitogenic role of protein kinase B/Akt in beta-cells. Trümper, K., Trümper, A., Trusheim, H., Arnold, R., Göke, B., Hörsch, D. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 association. Dixit, M., Zhuang, D., Ceacareanu, B., Hassid, A. Circ. Res. (2003) [Pubmed]

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