Gene Review:
Pik3r1 - phosphoinositide-3-kinase, regulatory...
Rattus norvegicus
Synonyms:
PI3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, ...
Yamada,
Ohnishi,
Sano,
Nakatani,
Ikeuchi,
Hatanaka,
Carini,
Grazia De Cesaris,
Splendore,
Baldanzi,
Nitti,
Alchera,
Filigheddu,
Domenicotti,
Pronzato,
Graziani,
Albano,
Franch,
Raissi,
Wang,
Zheng,
Bailey,
Price,
Todisco,
Ramamoorthy,
Witham,
Pausawasdi,
Srinivasan,
Dickinson,
Askari,
Krametter,
Takagi,
Sasakawa,
Besshoh,
Miyake-Takagi,
Takeo,
- Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis. Franch, H.A., Raissi, S., Wang, X., Zheng, B., Bailey, J.L., Price, S.R. Am. J. Physiol. Renal Physiol. (2004)
- Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway. Estève, P.O., Robledo, O., Potworowski, E.F., St-Pierre, Y. Biochem. Biophys. Res. Commun. (2002)
- Patterns of tyrosine phosphorylation differ in vascular hypertrophy and hyperplasia. Ali, S., Dorn, G.W. Am. J. Physiol. (1994)
- Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning. Carini, R., Grazia De Cesaris, M., Splendore, R., Baldanzi, G., Nitti, M.P., Alchera, E., Filigheddu, N., Domenicotti, C., Pronzato, M.A., Graziani, A., Albano, E. Gastroenterology (2004)
- The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Kennedy, S.G., Wagner, A.J., Conzen, S.D., Jordán, J., Bellacosa, A., Tsichlis, P.N., Hay, N. Genes Dev. (1997)
- PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Rong, R., Ahn, J.Y., Huang, H., Nagata, E., Kalman, D., Kapp, J.A., Tu, J., Worley, P.F., Snyder, S.H., Ye, K. Nat. Neurosci. (2003)
- A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Zhao, A.Z., Huan, J.N., Gupta, S., Pal, R., Sahu, A. Nat. Neurosci. (2002)
- Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells. Gao, B.B., Hansen, H., Chen, H.C., Feener, E.P. Biochem. J. (2006)
- A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti. Chung, W.H., Pak, K., Lin, B., Webster, N., Ryan, A.F. J. Assoc. Res. Otolaryngol. (2006)
- Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Wu, D.N., Pei, D.S., Wang, Q., Zhang, G.Y. Neurosci. Lett. (2006)
- Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP. McKee, S.C., Thompson, C.S., Sabourin, L.A., Hakim, A.M. Brain Res. (2006)
- Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine. Polk, D.B. Gastroenterology (1994)
- N-Methyl-D-aspartate inhibits apoptosis through activation of phosphatidylinositol 3-kinase in cerebellar granule neurons. A role for insulin receptor substrate-1 in the neurotrophic action of n-methyl-D-aspartate and its inhibition by ethanol. Zhang, F.X., Rubin, R., Rooney, T.A. J. Biol. Chem. (1998)
- Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells. Vetter, M.L., Bishop, J.M. Curr. Biol. (1995)
- Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin. Ferrand, A., Kowalski-Chauvel, A., Bertrand, C., Pradayrol, L., Fourmy, D., Dufresne, M., Seva, C. Exp. Cell Res. (2004)
- Signalling pathways of insulin-like growth factor-I that are augmented by cAMP in FRTL-5 cells. Ariga, M., Nedachi, T., Akahori, M., Sakamoto, H., Ito, Y., Hakuno, F., Takahashi, S. Biochem. J. (2000)
- Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes. Ridderstråle, M., Degerman, E., Tornqvist, H. J. Biol. Chem. (1995)
- Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide 3-kinase. Francis, S.C., Sunshine, C., Kirk, K.L. J. Biol. Chem. (2002)
- Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Gottschalk, W.A., Jiang, H., Tartaglia, N., Feng, L., Figurov, A., Lu, B. Learn. Mem. (1999)
- The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. Marrero, M.B., Papke, R.L., Bhatti, B.S., Shaw, S., Bencherif, M. J. Pharmacol. Exp. Ther. (2004)
- Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase. Beslu, N., LaRose, J., Casteran, N., Birnbaum, D., Lecocq, E., Dubreuil, P., Rottapel, R. J. Biol. Chem. (1996)
- Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons. Yamada, M., Ohnishi, H., Sano, S., Araki, T., Nakatani, A., Ikeuchi, T., Hatanaka, H. J. Neurochem. (1999)
- Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of phosphatidylinositol 3-kinase in the rat hippocampus. Takagi, N., Sasakawa, K., Besshoh, S., Miyake-Takagi, K., Takeo, S. J. Neurochem. (2003)
- Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases. Li, Z., Wahl, M.I., Eguinoa, A., Stephens, L.R., Hawkins, P.T., Witte, O.N. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases. Siu, M.K., Wong, C.H., Lee, W.M., Cheng, C.Y. J. Biol. Chem. (2005)
- Molecular mechanisms for the antiapoptotic action of gastrin. Todisco, A., Ramamoorthy, S., Witham, T., Pausawasdi, N., Srinivasan, S., Dickinson, C.J., Askari, F.K., Krametter, D. Am. J. Physiol. Gastrointest. Liver Physiol. (2001)
- Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina, L., Gruppuso, P.A., Wands, J.R. Gastroenterology (2003)
- Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons. Yamada, M., Ohnishi, H., Sano, S., Nakatani, A., Ikeuchi, T., Hatanaka, H. J. Biol. Chem. (1997)
- Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Ming, G., Song, H., Berninger, B., Inagaki, N., Tessier-Lavigne, M., Poo, M. Neuron (1999)
- nitric oxide triggers the phosphatidylinositol 3-kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1. Tejedo, J.R., Cahuana, G.M., Ramírez, R., Esbert, M., Jiménez, J., Sobrino, F., Bedoya, F.J. Endocrinology (2004)
- Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid rafts. Zschocke, J., Bayatti, N., Behl, C. Glia (2005)
- Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. Jiang, Z.Y., Lin, Y.W., Clemont, A., Feener, E.P., Hein, K.D., Igarashi, M., Yamauchi, T., White, M.F., King, G.L. J. Clin. Invest. (1999)
- Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. Folli, F., Saad, M.J., Backer, J.M., Kahn, C.R. J. Biol. Chem. (1992)
- Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes. Elberg, G., He, Z., Li, J., Sekar, N., Shechter, Y. Diabetes (1997)