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Gene Review

g  -  garnet

Drosophila melanogaster

Synonyms: AP-3 complex subunit delta, AP-3delta, AP3delta, CG10986, CG11197, ...
 
 
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High impact information on g

  • As expected, DE-cadherin-Delta beta did not substitute for DE-cadherin in these processes, although it retained some residual activity [1].
  • Furthermore, Notch lacking the carboxyl terminus functions as a receptor for Delta. These results suggest that Notch activities during development include generation and activity of a truncated receptor we designate NDeltaCterm [2].
  • Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet [3].
  • We report here that a defect in a gene encoding a putative coat adaptor protein leads to the eye color defect of garnet mutants [3].
  • Within somitic precursors, HRT1 and HRT3 exhibited dynamic expression in the presomitic mesoderm, mirroring the expression of other components of Notch-Delta signaling pathways [4].
 

Biological context of g

  • Thus, the eye pigmentation defect in the Drosophila garnet mutant may be attributed to compromised function of a coat protein involved in intracellular transport processes required for biogenesis or function of pigment granules [3].
  • Enhancer of garnet/deltaAP-3 is a cryptic allele of the white gene and identifies the intracellular transport system for the white protein [5].
  • The w(e(g)) allele also enhances mutations in the subset of other eye-color genes with phenotypes similar to garnet [5].
  • The garnet gene is a member of a group of other Drosophila eye colour genes that have been shown, or proposed, to function in intracellular protein transport [5].
 

Anatomical context of g

 

Other interactions of g

  • The additive effect on pigmentation and the predicted protein products of these genes suggest that the garnet/AP-3 transport system ensures the correct intracellular localization of the white gene product [5].
  • The frequency of mutations at the different loci encompassed a wide range: while no mutations were recovered at the raspberry and carnation loci, at others, the numbers ranged from 1 at echinus to 31 at garnet; in addition, the proportion of mutations that was male-viable was also different, depending on the locus [8].

References

  1. Binding site for p120/delta-catenin is not required for Drosophila E-cadherin function in vivo. Pacquelet, A., Lin, L., Rorth, P. J. Cell Biol. (2003) [Pubmed]
  2. Analysis of notch lacking the carboxyl terminus identified in Drosophila embryos. Wesley, C.S., Saez, L. J. Cell Biol. (2000) [Pubmed]
  3. Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet. Ooi, C.E., Moreira, J.E., Dell'Angelica, E.C., Poy, G., Wassarman, D.A., Bonifacino, J.S. EMBO J. (1997) [Pubmed]
  4. HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Nakagawa, O., Nakagawa, M., Richardson, J.A., Olson, E.N., Srivastava, D. Dev. Biol. (1999) [Pubmed]
  5. Enhancer of garnet/deltaAP-3 is a cryptic allele of the white gene and identifies the intracellular transport system for the white protein. Lloyd, V.K., Sinclair, D.A., Alperyn, M., Grigliatti, T.A. Genome (2002) [Pubmed]
  6. A genetic and molecular characterization of the garnet gene of Drosophila melanogaster. Lloyd, V.K., Sinclair, D.A., Wennberg, R., Warner, T.S., Honda, B.M., Grigliatti, T.A. Genome (1999) [Pubmed]
  7. Characterization of sepiapterin reductase activity from Drosophila melanogaster. Ruiz-Vázquez, P., Silva, F.J., Ferré, J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1996) [Pubmed]
  8. Is there a proportionality between the spontaneous and the X-ray-induction rates of mutations? Experiments with mutations at 13 X-chromosome loci in Drosophila melanogaster. Shukla, P.T., Sankaranarayanan, K., Sobels, F.H. Mutat. Res. (1979) [Pubmed]
 
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