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Gene Review

plu  -  plutonium

Drosophila melanogaster

Synonyms: CG9183, DNA replication inhibitor plutonium, Dmel\CG9183, PLU, Plu
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Disease relevance of plu

  • Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu [1].

High impact information on plu


Biological context of plu


Anatomical context of plu


Physical interactions of plu

  • PNG is a protein kinase that is in a complex with PLU [6].

Other interactions of plu


  1. giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Renault, A.D., Zhang, X.H., Alphey, L.S., Frenz, L.M., Glover, D.M., Saunders, R.D., Axton, J.M. Development (2003) [Pubmed]
  2. The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization. Shamanski, F.L., Orr-Weaver, T.L. Cell (1991) [Pubmed]
  3. The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions. Lee, L.A., Van Hoewyk, D., Orr-Weaver, T.L. Genes Dev. (2003) [Pubmed]
  4. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. Axton, J.M., Shamanski, F.L., Young, L.M., Henderson, D.S., Boyd, J.B., Orr-Weaver, T.L. EMBO J. (1994) [Pubmed]
  5. Drosophila PLUTONIUM protein is a specialized cell cycle regulator required at the onset of embryogenesis. Elfring, L.K., Axton, J.M., Fenger, D.D., Page, A.W., Carminati, J.L., Orr-Weaver, T.L. Mol. Biol. Cell (1997) [Pubmed]
  6. A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a target. Lee, L.A., Elfring, L.K., Bosco, G., Orr-Weaver, T.L. Genetics (2001) [Pubmed]
  7. Identification of plu genes and cis-acting elements of PCNA in the Drosophila genus using conservation of gene order. Renault, A.D., Axton, J.M. Gene (2003) [Pubmed]
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