The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NHLH2  -  nescient helix loop helix 2

Homo sapiens

Synonyms: BHLHA34, Class A basic helix-loop-helix protein 34, HEN-2, HEN2, Helix-loop-helix protein 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NHLH2

  • Genetic analysis of NHLH2 and its putative role in bovine body weight control [1].
  • These results suggest that the deregulated expression of neuronal-specific LMO3 and HEN2 contributes to the genesis and progression of human neuroblastoma in a lineage-specific manner [2].
  • Nhlh2 mutations unlikely underlie severe human obesity [3].
  • In mice, targeted deletion of the neuronal transcription factor Nhlh2 results in adult-onset obesity because of reduced exercise and infertility because of reduced sexual behaviour [1].

High impact information on NHLH2


Biological context of NHLH2

  • Both NSCL-1 and NSCL-2 genes are active only in postmitotic neurons, indicating a role for neuronal cell migration and/or differentiation within the sensory system [5].

Anatomical context of NHLH2

  • Nhlh2 (NHLH2 for humans) is expressed in the hypothalamus, particularly in neurons that have been shown to regulate energy balance [1].

Other interactions of NHLH2


  1. Genetic analysis of NHLH2 and its putative role in bovine body weight control. Brennan, K.M., Vella, K.R., Good, D.J. Anim. Genet. (2006) [Pubmed]
  2. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Aoyama, M., Ozaki, T., Inuzuka, H., Tomotsune, D., Hirato, J., Okamoto, Y., Tokita, H., Ohira, M., Nakagawara, A. Cancer Res. (2005) [Pubmed]
  3. A two-base deletion -439delGC in the melanocortin-4 receptor promoter associated with early-onset obesity. Valli-Jaakola, K., Palvimo, J.J., Lipsanen-Nyman, M., Salomaa, V., Peltonen, L., Kontula, K., Schalin-Jäntti, C. Horm. Res. (2006) [Pubmed]
  4. HEN1 encodes a 20-kilodalton phosphoprotein that binds an extended E-box motif as a homodimer. Brown, L., Baer, R. Mol. Cell. Biol. (1994) [Pubmed]
  5. Functional redundancy of NSCL-1 and NeuroD during development of the petrosal and vestibulocochlear ganglia. Kr??ger, M., Schmid, T., Kr??ger, S., Bober, E., Braun, T. Eur. J. Neurosci. (2006) [Pubmed]
  6. Two new Drosophila genes related to human hematopoietic and neurogenic transcription factors. Varterasian, M., Lipkowitz, S., Karsch-Mizrachi, I., Paterson, B., Kirsch, I. Cell Growth Differ. (1993) [Pubmed]
WikiGenes - Universities