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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Vestibular Nerve

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Disease relevance of Vestibular Nerve


High impact information on Vestibular Nerve

  • Likewise, it seems clear that an excitatory amino acid, probably glutamate, is the major transmitter used by the vestibular nerve in its synapses with neurones of the brainstem vestibular nucleus [6].
  • Immunocytochemical studies using antibodies to the NF2 protein showed complete absence of staining in tumor Schwann cells, whereas staining was observed in normal vestibular nerve [7].
  • Electrophysiological recordings from abducens motoneurons and internuclear neurons revealed a marked reduction in the slow positivity of the orthodromic extracellular potential elicited by ipsilateral vestibular nerve stimulation following systemic administration of strychnine, an antagonist of glycine [8].
  • Secretory function of the vestibular nerve calyx suggested by presence of vesicles, synapsin I, and synaptophysin [9].
  • 4. The reversal potentials for responses to ionophoretically applied glycine and GABA average about --83 mV, the same as that for the inhibitory post-synaptic potential (i.p.s.p.) produced in Müller cells by stimulation of the ipsilateral vestibular nerve [10].

Chemical compound and disease context of Vestibular Nerve


Biological context of Vestibular Nerve


Anatomical context of Vestibular Nerve


Associations of Vestibular Nerve with chemical compounds

  • This negative correlation could have resulted from a preferential activation of NMDA receptors via thick vestibular nerve afferent fibers [13].
  • The responses of these cells to depolarizing and hyperpolarizing current pulses and their postsynaptic responses to vestibular nerve stimulation were recorded, while simultaneously biocytin was injected for subsequent morphogenetic analysis [19].
  • Stimulation of the ipsilateral vestibular nerve evoked IPSPs at 1.4 ms that were reversed after injection of current and/or chloride ions. gamma-Aminobutyric acid (GABA) antibodies labeled inhibitory neurons in vestibular subdivisions with axons projecting into the ipsilateral medial longitudinal fasciculus (MLF) [20].
  • In Scarpa's ganglion of the rat, all cells were immunoreactive for glutamate, about 12% for colocalized glycine, and none for GABA or beta-alanine [21].
  • In the majority of LVN polysynaptic neurons that responded to antidromic stimulation of the ipsilateral or contralateral abducens nucleus, orthodromic spikes elicited by vestibular nerve stimulation were inhibited by DR conditioning stimulation and the iontophoretic application of 5-HT [22].

Gene context of Vestibular Nerve


Analytical, diagnostic and therapeutic context of Vestibular Nerve


  1. Different sensitivity to hypoxia in neuronal activities of lateral vestibular and spinal trigeminal nuclei. Yoshida, S., Sasa, M., Takaori, S. Stroke (1988) [Pubmed]
  2. Tapping the head activates the vestibular system: a new use for the clinical reflex hammer. Halmagyi, G.M., Yavor, R.A., Colebatch, J.G. Neurology (1995) [Pubmed]
  3. Immunohistochemistry study of human vestibular nerve schwannoma differentiation. Hung, G., Colton, J., Fisher, L., Oppenheimer, M., Faudoa, R., Slattery, W., Linthicum, F. Glia (2002) [Pubmed]
  4. Mossy fiber neck and second-order labyrinthine projections to cat flocculus. Wilson, V.J., Maeda, M., Franck, J.I., Shimazu, H. J. Neurophysiol. (1976) [Pubmed]
  5. Vestibular nerve section versus intratympanic gentamicin for Meniere's disease. Hillman, T.A., Chen, D.A., Arriaga, M.A. Laryngoscope (2004) [Pubmed]
  6. Recent advances in the pharmacology of the vestibulo-ocular reflex system. Smith, P.F., Darlington, C.L. Trends Pharmacol. Sci. (1996) [Pubmed]
  7. Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. Sainz, J., Huynh, D.P., Figueroa, K., Ragge, N.K., Baser, M.E., Pulst, S.M. Hum. Mol. Genet. (1994) [Pubmed]
  8. Evidence for glycine as an inhibitory neurotransmitter of vestibular, reticular, and prepositus hypoglossi neurons that project to the cat abducens nucleus. Spencer, R.F., Wenthold, R.J., Baker, R. J. Neurosci. (1989) [Pubmed]
  9. Secretory function of the vestibular nerve calyx suggested by presence of vesicles, synapsin I, and synaptophysin. Scarfone, E., Demêmes, D., Jahn, R., De Camilli, P., Sans, A. J. Neurosci. (1988) [Pubmed]
  10. Glycine, GABA and synaptic inhibition of reticulospinal neurones of lamprey. Matthews, G., Wickelgren, W.O. J. Physiol. (Lond.) (1979) [Pubmed]
  11. The primary vestibulocerebellar projection in the rabbit: absence of primary afferents in the flocculus. Gerrits, N.M., Epema, A.H., van Linge, A., Dalm, E. Neurosci. Lett. (1989) [Pubmed]
  12. Optical detection of developmental origin of synaptic function in the embryonic chick vestibulocochlear nuclei. Sato, K., Momose-Sato, Y. J. Neurophysiol. (2003) [Pubmed]
  13. Uncrossed disynaptic inhibition of second-order vestibular neurons and its interaction with monosynaptic excitation from vestibular nerve afferent fibers in the frog. Straka, H., Dieringer, N. J. Neurophysiol. (1996) [Pubmed]
  14. Effects of unilateral vestibular ganglionectomy on glutaminase activity in the vestibular nerve root and vestibular nuclear complex of the rat. Godfrey, D.A., Xu, J., Godfrey, M.A., Li, H., Rubin, A.M. J. Neurosci. Res. (2004) [Pubmed]
  15. Transient GABA immunoreactivity in cranial nerves of the chick embryo. von Bartheld, C.S., Rubel, E.W. J. Comp. Neurol. (1989) [Pubmed]
  16. Synaptic mechanisms of interaction between Deiters' nucleus and the nuclei of some cranial nerves. Fanardjian, V.V., Sarkisian, V.S. Neuroscience (1988) [Pubmed]
  17. Functional organization of vestibular and visual inputs to neck and forelimb motoneurons in the frog. Maeda, M., Magherini, P.C., Precht, W. J. Neurophysiol. (1977) [Pubmed]
  18. Quantitative distribution of choline acetyltransferase and acetylcholinesterase activities in the rat cochlear nucleus. Godfrey, D.A., Matschinsky, F.M. J. Histochem. Cytochem. (1981) [Pubmed]
  19. Ontogeny of electrophysiological properties and dendritic pattern in second-order chick vestibular neurons. Peusner, K.D., Giaume, C. J. Comp. Neurol. (1997) [Pubmed]
  20. Excitatory and inhibitory vestibular pathways to the extraocular motor nuclei in goldfish. Graf, W., Spencer, R., Baker, H., Baker, R. J. Neurophysiol. (1997) [Pubmed]
  21. Size-related colocalization of glycine and glutamate immunoreactivity in frog and rat vestibular afferents. Reichenberger, I., Dieringer, N. J. Comp. Neurol. (1994) [Pubmed]
  22. Inhibition of lateral vestibular nucleus neurons by 5-hydroxytryptamine derived from the dorsal raphe nucleus. Kishimoto, T., Sasa, M., Takaori, S. Brain Res. (1991) [Pubmed]
  23. Dlx gene expression during chick inner ear development. Brown, S.T., Wang, J., Groves, A.K. J. Comp. Neurol. (2005) [Pubmed]
  24. Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomas. Lasak, J.M., Welling, D.B., Akhmametyeva, E.M., Salloum, M., Chang, L.S. Laryngoscope (2002) [Pubmed]
  25. Select types of supporting cell in the inner ear express aquaporin-4 water channel protein. Takumi, Y., Nagelhus, E.A., Eidet, J., Matsubara, A., Usami, S., Shinkawa, H., Nielsen, S., Ottersen, O.P. Eur. J. Neurosci. (1998) [Pubmed]
  26. Subcellular immunolocalization of NMDA receptor subunit NR1, 2A, 2B in the rat vestibular periphery. Ishiyama, G., Lopez, I., Williamson, R., Acuna, D., Ishiyama, A. Brain Res. (2002) [Pubmed]
  27. Cyclin D(1) and D(3) expression in vestibular schwannomas. Neff, B.A., Oberstien, E., Lorenz, M., Chaudhury, A.R., Welling, D.B., Chang, L.S. Laryngoscope (2006) [Pubmed]
  28. Vestibular nerve input to neck and shoulder regions of lateral cuneate nucleus. Jensen, D.W., Thompson, G.C. Brain Res. (1983) [Pubmed]
  29. Factors influencing results with streptomycin perfusion of the labyrinth. Shea, J.J., Ge, X. The American journal of otology. (1993) [Pubmed]
  30. Release of glutamate from the vestibular nerve in the medial vestibular nucleus as a neurotransmitter: in vivo microdialysis study. Yamanaka, T., Sasa, M., Matsunaga, T. Acta oto-laryngologica. Supplementum. (1995) [Pubmed]
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