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Gene Review

NHLH1  -  nescient helix loop helix 1

Homo sapiens

Synonyms: BHLHA35, Class A basic helix-loop-helix protein 35, HEN-1, HEN1, Helix-loop-helix protein 1, ...
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Disease relevance of NHLH1


Psychiatry related information on NHLH1


High impact information on NHLH1


Chemical compound and disease context of NHLH1


Biological context of NHLH1


Anatomical context of NHLH1


Associations of NHLH1 with chemical compounds


Physical interactions of NHLH1

  • By mammalian two-hybrid analysis, we show that HEN1 interacts with both LMO2 and LMO4 [13].

Other interactions of NHLH1


Analytical, diagnostic and therapeutic context of NHLH1

  • Methods: Manual tracing of the STP in NSCLP males and matched controls was performed on magnetic resonance imaging (MRI) scans [3].
  • Examination of 12- and 13-day mouse embryos by in situ hybridization revealed expression of NSCL in the developing nervous system [27].
  • We report here the molecular cloning and chromosomal localization of an additional member of the helix-loop-helix (HLH) family of transcription factors, NSCL [27].
  • Gel mobility shift assays show that NSCL-1 only binds DNA as a heterodimeric complex with the ME1a E-protein [28].
  • PURPOSE: To evaluate brain morphology of adult males with nonsyndromic clefts of the lip and/or palate (NSCLP) in comparison to a matched healthy control group [29].


  1. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Aoyama, M., Ozaki, T., Inuzuka, H., Tomotsune, D., Hirato, J., Okamoto, Y., Tokita, H., Ohira, M., Nakagawara, A. Cancer Res. (2005) [Pubmed]
  2. Helix-loop-helix genes translocated in lymphoid leukemia. Visvader, J., Begley, C.G. Trends Biochem. Sci. (1991) [Pubmed]
  3. Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficits. Shriver, A.S., Canady, J., Richman, L., Andreasen, N.C., Nopoulos, P. Journal of child psychology and psychiatry, and allied disciplines. (2006) [Pubmed]
  4. Functional redundancy of NSCL-1 and NeuroD during development of the petrosal and vestibulocochlear ganglia. Kr??ger, M., Schmid, T., Kr??ger, S., Bober, E., Braun, T. Eur. J. Neurosci. (2006) [Pubmed]
  5. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Iavarone, A., Garg, P., Lasorella, A., Hsu, J., Israel, M.A. Genes Dev. (1994) [Pubmed]
  6. Inhibition of myeloid differentiation by the helix-loop-helix protein Id. Kreider, B.L., Benezra, R., Rovera, G., Kadesch, T. Science (1992) [Pubmed]
  7. A partnership between the dioxin receptor and a basic helix-loop-helix protein. Johnson, E.F. Science (1991) [Pubmed]
  8. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. German, M.S., Wang, J., Chadwick, R.B., Rutter, W.J. Genes Dev. (1992) [Pubmed]
  9. TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif. Beckmann, H., Su, L.K., Kadesch, T. Genes Dev. (1990) [Pubmed]
  10. A CLOCK-less clock. Asher, G., Schibler, U. Trends Cell Biol. (2006) [Pubmed]
  11. Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). Sjögren, H., Wedell, B., Meis-Kindblom, J.M., Kindblom, L.G., Stenman, G., Kindblom, J.M. Cancer Res. (2000) [Pubmed]
  12. Helix-loop-helix proteins in mammary gland development and breast cancer. Desprez, P.Y., Sumida, T., Coppé, J.P. Journal of mammary gland biology and neoplasia. (2003) [Pubmed]
  13. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Manetopoulos, C., Hansson, A., Karlsson, J., Jönsson, J.I., Axelson, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  14. A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. Lipkowitz, S., Göbel, V., Varterasian, M.L., Nakahara, K., Tchorz, K., Kirsch, I.R. J. Biol. Chem. (1992) [Pubmed]
  15. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. Chen, Q., Cheng, J.T., Tasi, L.H., Schneider, N., Buchanan, G., Carroll, A., Crist, W., Ozanne, B., Siciliano, M.J., Baer, R. EMBO J. (1990) [Pubmed]
  16. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Valge-Archer, V.E., Osada, H., Warren, A.J., Forster, A., Li, J., Baer, R., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. Quertermous, E.E., Hidai, H., Blanar, M.A., Quertermous, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (ID-1) is activated by all-trans retinoic acid in normal human keratinocytes. Villano, C.M., White, L.A. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  19. Proneural Basic Helix-Loop-Helix Proteins and Epidermal Growth Factor Receptor Signaling Coordinately Regulate Cell Type Specification and cdk Inhibitor Expression during Development. Sukhanova, M.J., Deb, D.K., Gordon, G.M., Matakatsu, M.T., Du, W. Mol. Cell. Biol. (2007) [Pubmed]
  20. Helix-loop-helix peptides as scaffolds for the construction of bridged metal assemblies in proteins: the spectroscopic A-cluster structure in carbon monoxide dehydrogenase. Laplaza, C.E., Holm, R.H. J. Am. Chem. Soc. (2001) [Pubmed]
  21. Molecular Architecture of the DNA-Binding Region and Its Relationship to Classification of Basic Helix-Loop-Helix Proteins. Atchley, W.R., Zhao, J. Mol. Biol. Evol. (2007) [Pubmed]
  22. Phase II studies of 4'-iodo-4'-deoxydoxorubicin in advanced non-small cell lung, colon and breast cancers. Sessa, C., Calabresi, F., Cavalli, F., Cerny, T., Liati, P., Skovsgaard, T., Sorio, R., Kaye, S.B. Ann. Oncol. (1991) [Pubmed]
  23. Two new Drosophila genes related to human hematopoietic and neurogenic transcription factors. Varterasian, M., Lipkowitz, S., Karsch-Mizrachi, I., Paterson, B., Kirsch, I. Cell Growth Differ. (1993) [Pubmed]
  24. Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Miyamoto, A., Cui, X., Naumovski, L., Cleary, M.L. Mol. Cell. Biol. (1996) [Pubmed]
  25. The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. Wang, J., Jani-Sait, S.N., Escalon, E.A., Carroll, A.J., de Jong, P.J., Kirsch, I.R., Aplan, P.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  26. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Hsu, H.L., Wadman, I., Baer, R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  27. Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. Begley, C.G., Lipkowitz, S., Göbel, V., Mahon, K.A., Bertness, V., Green, A.R., Gough, N.M., Kirsch, I.R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  28. Expression of the bHLH gene NSCL-1 suggests a role in regulating cerebellar granule cell growth and differentiation. Uittenbogaard, M., Peavy, D.R., Chiaramello, A. J. Neurosci. Res. (1999) [Pubmed]
  29. Structural brain abnormalities in adult males with clefts of the lip and/or palate. Nopoulos, P., Berg, S., Canady, J., Richman, L., Van Demark, D., Andreasen, N.C. Genet. Med. (2002) [Pubmed]
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