Gene Review:
Nhlh1 - nescient helix loop helix 1
Mus musculus
Synonyms:
HEN-1, Helix-loop-helix protein 1, Hen1, NSCL-1, Nescient helix loop helix 1, ...
- Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice. Cogliati, T., Good, D.J., Haigney, M., Delgado-Romero, P., Eckhaus, M.A., Koch, W.J., Kirsch, I.R. Mol. Cell. Biol. (2002)
- NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. Krüger, M., Ruschke, K., Braun, T. EMBO J. (2004)
- ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Osada, H., Tatematsu, Y., Yatabe, Y., Horio, Y., Takahashi, T. Cancer Res. (2005)
- Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Hoek, K., Rimm, D.L., Williams, K.R., Zhao, H., Ariyan, S., Lin, A., Kluger, H.M., Berger, A.J., Cheng, E., Trombetta, E.S., Wu, T., Niinobe, M., Yoshikawa, K., Hannigan, G.E., Halaban, R. Cancer Res. (2004)
- The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells. Shoji, W., Yamamoto, T., Obinata, M. J. Biol. Chem. (1994)
- Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development. Wilson, R.B., Kiledjian, M., Shen, C.P., Benezra, R., Zwollo, P., Dymecki, S.M., Desiderio, S.V., Kadesch, T. Mol. Cell. Biol. (1991)
- Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Good, D.J., Porter, F.D., Mahon, K.A., Parlow, A.F., Westphal, H., Kirsch, I.R. Nat. Genet. (1997)
- Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Lee, J.E., Hollenberg, S.M., Snider, L., Turner, D.L., Lipnick, N., Weintraub, H. Science (1995)
- A CLOCK-less clock. Asher, G., Schibler, U. Trends Cell Biol. (2006)
- Helix-loop-helix proteins and lymphocyte development. Murre, C. Nat. Immunol. (2005)
- E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Sayegh, C.E., Quong, M.W., Agata, Y., Murre, C. Nat. Immunol. (2003)
- Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. Begley, C.G., Lipkowitz, S., Göbel, V., Mahon, K.A., Bertness, V., Green, A.R., Gough, N.M., Kirsch, I.R. Proc. Natl. Acad. Sci. U.S.A. (1992)
- A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. Wang, S., Sdrulla, A., Johnson, J.E., Yokota, Y., Barres, B.A. Neuron (2001)
- An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Christy, B.A., Sanders, L.K., Lau, L.F., Copeland, N.G., Jenkins, N.A., Nathans, D. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Desprez, P.Y., Hara, E., Bissell, M.J., Campisi, J. Mol. Cell. Biol. (1995)
- FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Liang, L., Soyal, S.M., Dean, J. Development (1997)
- Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Sirotnak, F.M., Zakowski, M.F., Miller, V.A., Scher, H.I., Kris, M.G. Clin. Cancer Res. (2000)
- Structural features of the murine gene encoding the RI beta subunit of cAMP-dependent protein kinase. Clegg, C.H., Koeiman, N.R., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Neubauer, M.G. Mol. Cell. Neurosci. (1994)
- Helix-loop-helix transcription factors regulate Id2 gene promoter activity. Neuman, K., Nornes, H.O., Neuman, T. FEBS Lett. (1995)
- Preclinical antitumor activity of 4'-thio-beta-D-arabinofuranosylcytosine (4'-thio-ara-C). Waud, W.R., Gilbert, K.S., Shepherd, R.V., Montgomery, J.A., Secrist, J.A. Cancer Chemother. Pharmacol. (2003)
- Id-1 promotes proliferation of p53-deficient esophageal cancer cells. Hui, C.M., Cheung, P.Y., Ling, M.T., Tsao, S.W., Wang, X., Wong, Y.C., Cheung, A.L. Int. J. Cancer (2006)
- Sequence and expression analysis of Nhlh1: a basic helix-loop-helix gene implicated in neurogenesis. Murdoch, J.N., Eddleston, J., Leblond-Bourget, N., Stanier, P., Copp, A.J. Dev. Genet. (1999)
- Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1. Tournay, O., Benezra, R. Mol. Cell. Biol. (1996)
- Expression of bHLH transcription factors NSCL1 and NSCL2 in the mouse olfactory system. Suzuki, Y., Tsuruga, E., Yajima, T., Takeda, M. Chem. Senses (2003)
- Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Peers, B., Leonard, J., Sharma, S., Teitelman, G., Montminy, M.R. Mol. Endocrinol. (1994)
- Nhlh1, a basic helix-loop-helix transcription factor, is very tightly linked to the mouse looptail (Lp) mutation. Mullick, A., Groulx, N., Trasler, D., Gros, P. Mamm. Genome (1995)
- Id3 prevents differentiation of preadipose cells. Moldes, M., Lasnier, F., Fève, B., Pairault, J., Djian, P. Mol. Cell. Biol. (1997)
- The neuronal basic helix-loop-helix transcription factor NSCL-1 is dispensable for normal neuronal development. Krüger, M., Braun, T. Mol. Cell. Biol. (2002)
- Expression of the helix-loop-helix genes Id-1 and NSCL-1 during cerebellar development. Duncan, M.K., Bordas, L., Dicicco-Bloom, E., Chada, K.K. Dev. Dyn. (1997)
- Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Yasunami, M., Suzuki, K., Maruyama, H., Kawakami, H., Nagai, Y., Hagiwara, M., Ohkubo, H. Biochem. Biophys. Res. Commun. (1996)
- The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Ihle, N.T., Paine-Murrieta, G., Berggren, M.I., Baker, A., Tate, W.R., Wipf, P., Abraham, R.T., Kirkpatrick, D.L., Powis, G. Mol. Cancer Ther. (2005)