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Gene Review

NPY2R  -  neuropeptide Y receptor Y2

Homo sapiens

Synonyms: NPY-Y2 receptor, NPY2-R, Neuropeptide Y receptor type 2, Y2 receptor
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Disease relevance of NPY2R


Psychiatry related information on NPY2R

  • These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects [4].

High impact information on NPY2R

  • AIMS/HYPOTHESIS: The gene encoding neuropeptide Y receptor Y2 (NPY2R) is widely expressed in the central nervous system, with particularly high abundance in the hypothalamus, which is known to be important for appetite regulation [2].
  • METHODS: The coding region of NPY2R was analysed for mutations in 48 obese Danish white subjects and two silent substitutions were identified: SNPs 1 and 2 (rs1047214 and rs2880415) [2].
  • Both basal and forskolin-stimulated cAMP levels were inhibited by 100 nM NPY and by 100 nM NPY(13-36), a selective agonist of the NPY Y2-receptor subtype [5].
  • NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells [6].
  • N-terminal truncation of PYY to abrogate affinity for the NPY1 and NPY5 receptors and subsequent N-terminal modification with aminobenzoic analogs to restore NPY2 receptor potency results in a series of highly selective NPY2 receptor peptide agonists [7].

Biological context of NPY2R

  • Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene [8].
  • Activation of the NPY2 receptor to reduce appetite while avoiding stimulation of the NPY1 and NPY5 receptors that induce feeding provides a pharmaceutical approach to modulate food intake [7].
  • Previous studies demonstrated that NPY Y2 receptor knockout (KO) mice display an anxiolytic- and antidepressant-like phenotype compared with control animals [4].

Anatomical context of NPY2R


Associations of NPY2R with chemical compounds


  1. Neuropeptide Y expression in a mouse model of oxygen-induced retinopathy. Yoon, H.Z., Yan, Y., Geng, Y., Higgins, R.D. Clin. Experiment. Ophthalmol. (2002) [Pubmed]
  2. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. Torekov, S.S., Larsen, L.H., Andersen, G., Albrechtsen, A., Gl??mer, C., Borch-Johnsen, K., J??rgensen, T., Hansen, T., Pedersen, O. Diabetologia (2006) [Pubmed]
  3. Ventricular Fibrillation Induced by Ischemia-Reperfusion Is Not Prevented by the NPY Y2 Receptor Antagonist BIIE0246. Ilebekk, A., Eriksen, M., Sevre, K., Aspelin, T., Bj??rkman, J.A., Lyberg, T., Nordlander, M. J. Cardiovasc. Pharmacol. Ther. (2006) [Pubmed]
  4. Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout mice. Carvajal, C., Dumont, Y., Herzog, H., Quirion, R. J. Mol. Neurosci. (2006) [Pubmed]
  5. Neuropeptide Y modulates ATP-induced increases in internal calcium via the adenylate cyclase/protein kinase A system in a human neuroblastoma cell line. Soares Lemos, V., Bucher, B., Takeda, K. Biochem. J. (1997) [Pubmed]
  6. Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. Dimitrijević, M., Stanojević, S., Vujić, V., Beck-Sickinger, A., von Hörsten, S. Regul. Pept. (2005) [Pubmed]
  7. Identification of selective neuropeptide Y2 peptide agonists. Decarr, L.B., Buckholz, T.M., Coish, P.D., Fathi, Z., Fisk, S.E., Mays, M.R., O'connor, S.J., Lumb, K.J. Bioorg. Med. Chem. Lett. (2007) [Pubmed]
  8. Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. Ammar, D.A., Eadie, D.M., Wong, D.J., Ma, Y.Y., Kolakowski, L.F., Yang-Feng, T.L., Thompson, D.A. Genomics (1996) [Pubmed]
  9. Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues. Uddman, R., Möller, S., Nilsson, T., Nyström, S., Ekstrand, J., Edvinsson, L. Peptides (2002) [Pubmed]
  10. Neuropeptide Y rapidly reduces Period 1 and Period 2 mRNA levels in the hamster suprachiasmatic nucleus. Fukuhara, C., Brewer, J.M., Dirden, J.C., Bittman, E.L., Tosini, G., Harrington, M.E. Neurosci. Lett. (2001) [Pubmed]
  11. Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity. Barnham, K.J., Catalfamo, F., Pallaghy, P.K., Howlett, G.J., Norton, R.S. Biochim. Biophys. Acta (1999) [Pubmed]
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