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Gene Review

Neu3  -  neuraminidase 3

Mus musculus

Synonyms: Ganglioside sialidase, Membrane sialidase, N-acetyl-alpha-neuraminidase 3, Sialidase-3, ganglioside sialidase, ...
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Disease relevance of Neu3

  • A reduction of 70% of the plasma membrane-associated sialidase Neu3 activity, due to a corresponding reduction of the enzyme expression by transducing cells with a short hairpin RNA encoding a sequence target (complementary messenger of mouse Neu3), caused neurite elongation in Neuro2a murine neuroblastoma cells [1].

High impact information on Neu3


Biological context of Neu3


Anatomical context of Neu3


Other interactions of Neu3

  • T-cells also have significant levels of Neu-3 mRNAs, albeit much lower than those of Neu-1, whereas the levels of Neu-2 mRNAs are minimal [4].

Analytical, diagnostic and therapeutic context of Neu3

  • Western blot analysis and enzymic comparison with recombinant sialidases have revealed that Neu-3 is induced as a major isoform in activated cells [4].


  1. Induction of axonal differentiation by silencing plasma membrane-associated sialidase Neu3 in neuroblastoma cells. Valaperta, R., Valsecchi, M., Rocchetta, F., Aureli, M., Prioni, S., Prinetti, A., Chigorno, V., Sonnino, S. J. Neurochem. (2007) [Pubmed]
  2. Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation. Hasegawa, T., Yamaguchi, K., Wada, T., Takeda, A., Itoyama, Y., Miyagi, T. J. Biol. Chem. (2000) [Pubmed]
  3. Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts. Valaperta, R., Chigorno, V., Basso, L., Prinetti, A., Bresciani, R., Preti, A., Miyagi, T., Sonnino, S. FASEB J. (2006) [Pubmed]
  4. Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Wang, P., Zhang, J., Bian, H., Wu, P., Kuvelkar, R., Kung, T.T., Crawley, Y., Egan, R.W., Billah, M.M. Biochem. J. (2004) [Pubmed]
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