Gene Review:
NEU3 - sialidase 3 (membrane sialidase)
Homo sapiens
Synonyms:
Ganglioside sialidase, Membrane sialidase, N-acetyl-alpha-neuraminidase 3, Sialidase-3
- Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice. Sasaki, A., Hata, K., Suzuki, S., Sawada, M., Wada, T., Yamaguchi, K., Obinata, M., Tateno, H., Suzuki, H., Miyagi, T. J. Biol. Chem. (2003)
- Down-regulation of sialidase NEU4 may contribute to invasive properties of human colon cancers. Yamanami, H., Shiozaki, K., Wada, T., Yamaguchi, K., Uemura, T., Kakugawa, Y., Hujiya, T., Miyagi, T. Cancer Sci. (2007)
- Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility. Ueno, S., Saito, S., Wada, T., Yamaguchi, K., Satoh, M., Arai, Y., Miyagi, T. J. Biol. Chem. (2006)
- Carrier detection of sialidosis with partial beta-galactosidase deficiency by the assay of lysosomal sialidase in lymphocytes. Tsuji, S., Yamada, T., Ariga, T., Toyoshima, I., Yamaguchi, H., Kitahara, Y., Miyatake, T., Yamakawa, T. Ann. Neurol. (1984)
- Effects of cell surface ganglioside sialidase inhibition on growth control and differentiation of human neuroblastoma cells. Kopitz, J., Mühl, C., Ehemann, V., Lehmann, C., Cantz, M. Eur. J. Cell Biol. (1997)
- Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression. Kakugawa, Y., Wada, T., Yamaguchi, K., Yamanami, H., Ouchi, K., Sato, I., Miyagi, T. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Adult type neuronal storage disease with neuraminidase deficiency. Miyatake, T., Atsumi, T., Obayashi, T., Mizuno, Y., Ando, S., Ariga, T., Matsui-Nakamura, K., Yamada, T. Ann. Neurol. (1979)
- Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3. Kopitz, J., von Reitzenstein, C., André, S., Kaltner, H., Uhl, J., Ehemann, V., Cantz, M., Gabius, H.J. J. Biol. Chem. (2001)
- Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture. Kopitz, J., von Reitzenstein, C., Burchert, M., Cantz, M., Gabius, H.J. J. Biol. Chem. (1998)
- Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Monti, E., Bassi, M.T., Papini, N., Riboni, M., Manzoni, M., Venerando, B., Croci, G., Preti, A., Ballabio, A., Tettamanti, G., Borsani, G. Biochem. J. (2000)
- Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Monti, E., Bassi, M.T., Bresciani, R., Civini, S., Croci, G.L., Papini, N., Riboni, M., Zanchetti, G., Ballabio, A., Preti, A., Tettamanti, G., Venerando, B., Borsani, G. Genomics (2004)
- Homology modeling of human sialidase enzymes NEU1, NEU3 and NEU4 based on the crystal structure of NEU2: Hints for the design of selective NEU3 inhibitors. Magesh, S., Suzuki, T., Miyagi, T., Ishida, H., Kiso, M. J. Mol. Graph. Model. (2006)
- Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. Stamatos, N.M., Liang, F., Nan, X., Landry, K., Cross, A.S., Wang, L.X., Pshezhetsky, A.V. FEBS J. (2005)
- Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles. Yamaguchi, K., Hata, K., Wada, T., Moriya, S., Miyagi, T. Biochem. Biophys. Res. Commun. (2006)
- A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains. Wang, Y., Yamaguchi, K., Wada, T., Hata, K., Zhao, X., Fujimoto, T., Miyagi, T. J. Biol. Chem. (2002)
- Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. Kato, K., Shiga, K., Yamaguchi, K., Hata, K., Kobayashi, T., Miyazaki, K., Saijo, S., Miyagi, T. Biochem. J. (2006)
- Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase. Woronowicz, A., Amith, S.R., De Vusser, K., Laroy, W., Contreras, R., Basta, S., Szewczuk, M.R. Glycobiology (2007)
- Role of plasma membrane ganglioside sialidase of human neuroblastoma cells in growth control and differentiation. Kopitz, J., von Reitzenstein, C., Mühl, C., Cantz, M. Biochem. Biophys. Res. Commun. (1994)
- The plasma membrane ganglioside sialidase cofractionates with markers of lipid rafts. Kalka, D., von Reitzenstein, C., Kopitz, J., Cantz, M. Biochem. Biophys. Res. Commun. (2001)
- Site-directed mutagenesis of human membrane-associated ganglioside sialidase: identification of amino-acid residues contributing to substrate specificity. Wang, Y., Yamaguchi, K., Shimada, Y., Zhao, X., Miyagi, T. Eur. J. Biochem. (2001)